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Gene: TM4SF1 |
Gene summary for TM4SF1 |
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Gene information | Species | Human | Gene symbol | TM4SF1 | Gene ID | 4071 |
Gene name | transmembrane 4 L six family member 1 | |
Gene Alias | H-L6 | |
Cytomap | 3q25.1 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | P30408 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4071 | TM4SF1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.66e-03 | 2.11e-01 | 0.2585 |
4071 | TM4SF1 | AEH-subject5 | Human | Endometrium | AEH | 1.30e-27 | 7.75e-01 | -0.2953 |
4071 | TM4SF1 | EEC-subject3 | Human | Endometrium | EEC | 4.70e-11 | 5.86e-01 | -0.2525 |
4071 | TM4SF1 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 7.79e-04 | -1.73e-01 | -0.1917 |
4071 | TM4SF1 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 2.05e-02 | -1.62e-01 | -0.1916 |
4071 | TM4SF1 | LZE2D | Human | Esophagus | HGIN | 9.34e-03 | 1.38e+00 | 0.0642 |
4071 | TM4SF1 | LZE2T | Human | Esophagus | ESCC | 2.17e-05 | 1.12e+00 | 0.082 |
4071 | TM4SF1 | LZE3D | Human | Esophagus | HGIN | 3.28e-16 | 2.10e+00 | 0.0668 |
4071 | TM4SF1 | LZE4T | Human | Esophagus | ESCC | 3.97e-32 | 2.12e+00 | 0.0811 |
4071 | TM4SF1 | LZE5T | Human | Esophagus | ESCC | 4.77e-08 | 5.32e-01 | 0.0514 |
4071 | TM4SF1 | LZE7T | Human | Esophagus | ESCC | 8.38e-16 | 1.77e+00 | 0.0667 |
4071 | TM4SF1 | LZE8T | Human | Esophagus | ESCC | 1.25e-05 | 7.63e-01 | 0.067 |
4071 | TM4SF1 | LZE21D1 | Human | Esophagus | HGIN | 4.25e-03 | -8.72e-01 | 0.0632 |
4071 | TM4SF1 | LZE22T | Human | Esophagus | ESCC | 5.79e-11 | 1.54e+00 | 0.068 |
4071 | TM4SF1 | LZE24D1 | Human | Esophagus | HGIN | 3.87e-03 | -2.14e-01 | 0.054 |
4071 | TM4SF1 | LZE24T | Human | Esophagus | ESCC | 7.22e-08 | 7.11e-01 | 0.0596 |
4071 | TM4SF1 | LZE21T | Human | Esophagus | ESCC | 8.36e-03 | 6.25e-01 | 0.0655 |
4071 | TM4SF1 | LZE6T | Human | Esophagus | ESCC | 4.92e-17 | -1.31e+00 | 0.0845 |
4071 | TM4SF1 | P1T-E | Human | Esophagus | ESCC | 4.75e-02 | 3.15e+00 | 0.0875 |
4071 | TM4SF1 | P2T-E | Human | Esophagus | ESCC | 3.78e-46 | 2.43e+00 | 0.1177 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TM4SF1 | SNV | Missense_Mutation | rs199669677 | c.290N>G | p.Ala97Gly | p.A97G | P30408 | protein_coding | deleterious(0) | possibly_damaging(0.565) | TCGA-A2-A04Q-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
TM4SF1 | SNV | Missense_Mutation | novel | c.122A>C | p.Asn41Thr | p.N41T | P30408 | protein_coding | tolerated(0.06) | benign(0.122) | TCGA-AR-A1AP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
TM4SF1 | SNV | Missense_Mutation | novel | c.20N>T | p.Ala7Val | p.A7V | P30408 | protein_coding | deleterious(0) | possibly_damaging(0.749) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TM4SF1 | SNV | Missense_Mutation | c.62N>T | p.Cys21Phe | p.C21F | P30408 | protein_coding | deleterious(0) | probably_damaging(0.922) | TCGA-NH-A8F8-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD | |
TM4SF1 | SNV | Missense_Mutation | novel | c.347C>T | p.Ala116Val | p.A116V | P30408 | protein_coding | tolerated(0.36) | benign(0.026) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
TM4SF1 | SNV | Missense_Mutation | c.289N>T | p.Ala97Ser | p.A97S | P30408 | protein_coding | tolerated(0.09) | benign(0.143) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TM4SF1 | SNV | Missense_Mutation | c.86N>G | p.Tyr29Cys | p.Y29C | P30408 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
TM4SF1 | SNV | Missense_Mutation | c.308G>T | p.Gly103Val | p.G103V | P30408 | protein_coding | deleterious(0) | probably_damaging(0.927) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD | |
TM4SF1 | SNV | Missense_Mutation | c.229N>T | p.Gly77Cys | p.G77C | P30408 | protein_coding | deleterious(0.04) | probably_damaging(1) | TCGA-B5-A0K9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TM4SF1 | SNV | Missense_Mutation | rs745533363 | c.266C>T | p.Ala89Val | p.A89V | P30408 | protein_coding | deleterious(0.05) | possibly_damaging(0.59) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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