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Gene: TINAGL1 |
Gene summary for TINAGL1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TINAGL1 | Gene ID | 64129 |
| Gene name | tubulointerstitial nephritis antigen like 1 | |
| Gene Alias | ARG1 | |
| Cytomap | 1p35.2 | |
| Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9GZM7 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 64129 | TINAGL1 | P76T-E | Human | Esophagus | ESCC | 2.70e-51 | 1.43e+00 | 0.1207 |
| 64129 | TINAGL1 | P79T-E | Human | Esophagus | ESCC | 2.05e-27 | 8.45e-01 | 0.1154 |
| 64129 | TINAGL1 | P80T-E | Human | Esophagus | ESCC | 1.56e-10 | 4.38e-01 | 0.155 |
| 64129 | TINAGL1 | P82T-E | Human | Esophagus | ESCC | 2.23e-27 | 2.18e+00 | 0.1072 |
| 64129 | TINAGL1 | P83T-E | Human | Esophagus | ESCC | 4.92e-52 | 2.60e+00 | 0.1738 |
| 64129 | TINAGL1 | P84T-E | Human | Esophagus | ESCC | 3.46e-03 | 6.99e-01 | 0.0933 |
| 64129 | TINAGL1 | P89T-E | Human | Esophagus | ESCC | 7.79e-14 | 1.14e+00 | 0.1752 |
| 64129 | TINAGL1 | P91T-E | Human | Esophagus | ESCC | 1.15e-06 | 1.08e+00 | 0.1828 |
| 64129 | TINAGL1 | P104T-E | Human | Esophagus | ESCC | 3.57e-04 | 9.02e-01 | 0.0931 |
| 64129 | TINAGL1 | P107T-E | Human | Esophagus | ESCC | 1.05e-24 | 7.80e-01 | 0.171 |
| 64129 | TINAGL1 | P126T-E | Human | Esophagus | ESCC | 1.45e-16 | 1.72e+00 | 0.1125 |
| 64129 | TINAGL1 | P127T-E | Human | Esophagus | ESCC | 7.23e-09 | 3.75e-01 | 0.0826 |
| 64129 | TINAGL1 | P130T-E | Human | Esophagus | ESCC | 6.32e-17 | 7.18e-01 | 0.1676 |
| 64129 | TINAGL1 | S43 | Human | Liver | Cirrhotic | 2.73e-05 | -7.60e-02 | -0.0187 |
| 64129 | TINAGL1 | HCC1_Meng | Human | Liver | HCC | 2.42e-16 | -2.65e-01 | 0.0246 |
| 64129 | TINAGL1 | HCC2_Meng | Human | Liver | HCC | 4.27e-32 | 2.47e-01 | 0.0107 |
| 64129 | TINAGL1 | cirrhotic2 | Human | Liver | Cirrhotic | 1.89e-06 | 1.59e-01 | 0.0201 |
| 64129 | TINAGL1 | cirrhotic3 | Human | Liver | Cirrhotic | 1.37e-05 | 6.92e-02 | 0.0215 |
| 64129 | TINAGL1 | HCC1 | Human | Liver | HCC | 5.80e-37 | 2.26e-01 | 0.5336 |
| 64129 | TINAGL1 | HCC5 | Human | Liver | HCC | 8.53e-04 | -2.97e-01 | 0.4932 |
| Page: 1 2 3 4 5 6 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00161977 | Cervix | CC | endosomal transport | 48/2311 | 230/18723 | 1.65e-04 | 1.97e-03 | 48 |
| GO:0016197 | Colorectum | AD | endosomal transport | 90/3918 | 230/18723 | 1.88e-10 | 1.73e-08 | 90 |
| GO:00161971 | Colorectum | SER | endosomal transport | 61/2897 | 230/18723 | 1.03e-05 | 3.35e-04 | 61 |
| GO:00161972 | Colorectum | MSS | endosomal transport | 79/3467 | 230/18723 | 7.04e-09 | 4.39e-07 | 79 |
| GO:00161973 | Colorectum | FAP | endosomal transport | 56/2622 | 230/18723 | 1.79e-05 | 4.53e-04 | 56 |
| GO:001619715 | Esophagus | ESCC | endosomal transport | 168/8552 | 230/18723 | 2.28e-17 | 1.93e-15 | 168 |
| GO:001619711 | Liver | Cirrhotic | endosomal transport | 93/4634 | 230/18723 | 1.01e-07 | 2.93e-06 | 93 |
| GO:001619721 | Liver | HCC | endosomal transport | 154/7958 | 230/18723 | 4.74e-14 | 2.95e-12 | 154 |
| GO:00161979 | Oral cavity | OSCC | endosomal transport | 141/7305 | 230/18723 | 5.40e-12 | 2.06e-10 | 141 |
| GO:001619714 | Oral cavity | LP | endosomal transport | 98/4623 | 230/18723 | 1.65e-09 | 7.50e-08 | 98 |
| GO:001619731 | Oral cavity | NEOLP | endosomal transport | 41/2005 | 230/18723 | 7.41e-04 | 6.05e-03 | 41 |
| GO:00161978 | Prostate | BPH | endosomal transport | 62/3107 | 230/18723 | 4.54e-05 | 4.77e-04 | 62 |
| GO:001619713 | Prostate | Tumor | endosomal transport | 62/3246 | 230/18723 | 1.65e-04 | 1.47e-03 | 62 |
| GO:001619718 | Thyroid | PTC | endosomal transport | 128/5968 | 230/18723 | 6.26e-14 | 3.52e-12 | 128 |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TINAGL1 | SNV | Missense_Mutation | novel | c.446C>T | p.Ala149Val | p.A149V | Q9GZM7 | protein_coding | tolerated(0.52) | possibly_damaging(0.613) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| TINAGL1 | SNV | Missense_Mutation | novel | c.1209N>C | p.Lys403Asn | p.K403N | Q9GZM7 | protein_coding | deleterious(0) | probably_damaging(0.918) | TCGA-B6-A0RG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| TINAGL1 | SNV | Missense_Mutation | c.1318N>A | p.Val440Met | p.V440M | Q9GZM7 | protein_coding | deleterious(0.01) | benign(0.354) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
| TINAGL1 | SNV | Missense_Mutation | c.1253T>C | p.Leu418Pro | p.L418P | Q9GZM7 | protein_coding | tolerated(0.26) | benign(0.377) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| TINAGL1 | SNV | Missense_Mutation | c.820C>T | p.Arg274Cys | p.R274C | Q9GZM7 | protein_coding | tolerated(0.08) | possibly_damaging(0.896) | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| TINAGL1 | SNV | Missense_Mutation | c.842T>C | p.Phe281Ser | p.F281S | Q9GZM7 | protein_coding | deleterious(0) | probably_damaging(0.92) | TCGA-CM-6164-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| TINAGL1 | SNV | Missense_Mutation | c.917N>T | p.Ala306Val | p.A306V | Q9GZM7 | protein_coding | tolerated(0.3) | benign(0.003) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| TINAGL1 | SNV | Missense_Mutation | c.172N>G | p.Arg58Gly | p.R58G | Q9GZM7 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-DC-6157-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| TINAGL1 | SNV | Missense_Mutation | novel | c.1145N>T | p.Ser382Ile | p.S382I | Q9GZM7 | protein_coding | deleterious(0) | possibly_damaging(0.69) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| TINAGL1 | SNV | Missense_Mutation | novel | c.722N>A | p.Arg241His | p.R241H | Q9GZM7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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