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Gene: THG1L |
Gene summary for THG1L |
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Gene information | Species | Human | Gene symbol | THG1L | Gene ID | 54974 |
Gene name | tRNA-histidine guanylyltransferase 1 like | |
Gene Alias | ICF45 | |
Cytomap | 5q33.3 | |
Gene Type | protein-coding | GO ID | GO:0000966 | UniProtAcc | B4E366 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54974 | THG1L | HCC1 | Human | Liver | HCC | 2.68e-02 | 4.26e-01 | 0.5336 |
54974 | THG1L | HCC2 | Human | Liver | HCC | 2.25e-16 | 2.51e+00 | 0.5341 |
54974 | THG1L | HCC5 | Human | Liver | HCC | 4.05e-09 | 2.18e+00 | 0.4932 |
54974 | THG1L | S015 | Human | Liver | HCC | 2.62e-07 | 3.93e-01 | 0.2375 |
54974 | THG1L | S016 | Human | Liver | HCC | 1.38e-03 | 1.86e-01 | 0.2243 |
54974 | THG1L | S029 | Human | Liver | HCC | 1.50e-05 | 3.81e-01 | 0.2581 |
54974 | THG1L | C04 | Human | Oral cavity | OSCC | 2.64e-12 | 6.48e-01 | 0.2633 |
54974 | THG1L | C21 | Human | Oral cavity | OSCC | 2.26e-19 | 6.37e-01 | 0.2678 |
54974 | THG1L | C30 | Human | Oral cavity | OSCC | 9.53e-31 | 1.13e+00 | 0.3055 |
54974 | THG1L | C38 | Human | Oral cavity | OSCC | 9.86e-06 | 7.15e-01 | 0.172 |
54974 | THG1L | C43 | Human | Oral cavity | OSCC | 1.50e-18 | 4.37e-01 | 0.1704 |
54974 | THG1L | C46 | Human | Oral cavity | OSCC | 5.49e-12 | 3.28e-01 | 0.1673 |
54974 | THG1L | C57 | Human | Oral cavity | OSCC | 3.04e-03 | 1.61e-01 | 0.1679 |
54974 | THG1L | C06 | Human | Oral cavity | OSCC | 8.08e-03 | 5.99e-01 | 0.2699 |
54974 | THG1L | C08 | Human | Oral cavity | OSCC | 5.23e-06 | 2.07e-01 | 0.1919 |
54974 | THG1L | LN46 | Human | Oral cavity | OSCC | 6.96e-04 | 3.01e-01 | 0.1666 |
54974 | THG1L | SYSMH2 | Human | Oral cavity | OSCC | 6.44e-18 | 4.09e-01 | 0.2326 |
54974 | THG1L | SYSMH3 | Human | Oral cavity | OSCC | 6.59e-17 | 4.90e-01 | 0.2442 |
54974 | THG1L | SYSMH4 | Human | Oral cavity | OSCC | 3.10e-05 | 1.05e-01 | 0.1226 |
54974 | THG1L | SYSMH5 | Human | Oral cavity | OSCC | 2.86e-02 | 7.06e-02 | 0.0647 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:0006979111 | Esophagus | ESCC | response to oxidative stress | 303/8552 | 446/18723 | 7.15e-22 | 1.30e-19 | 303 |
GO:00080333 | Esophagus | ESCC | tRNA processing | 92/8552 | 127/18723 | 7.83e-10 | 1.93e-08 | 92 |
GO:00063992 | Esophagus | ESCC | tRNA metabolic process | 122/8552 | 179/18723 | 9.03e-10 | 2.19e-08 | 122 |
GO:00094512 | Esophagus | ESCC | RNA modification | 114/8552 | 167/18723 | 2.76e-09 | 6.04e-08 | 114 |
GO:00482844 | Esophagus | ESCC | organelle fusion | 94/8552 | 141/18723 | 3.72e-07 | 5.16e-06 | 94 |
GO:00064002 | Esophagus | ESCC | tRNA modification | 62/8552 | 90/18723 | 7.02e-06 | 7.04e-05 | 62 |
GO:00344713 | Esophagus | ESCC | ncRNA 5'-end processing | 18/8552 | 21/18723 | 1.81e-04 | 1.16e-03 | 18 |
GO:00009663 | Esophagus | ESCC | RNA 5'-end processing | 19/8552 | 23/18723 | 3.12e-04 | 1.85e-03 | 19 |
GO:00991163 | Esophagus | ESCC | tRNA 5'-end processing | 14/8552 | 16/18723 | 6.78e-04 | 3.56e-03 | 14 |
GO:00512623 | Esophagus | ESCC | protein tetramerization | 54/8552 | 87/18723 | 1.50e-03 | 7.06e-03 | 54 |
GO:00080532 | Esophagus | ESCC | mitochondrial fusion | 20/8552 | 27/18723 | 2.61e-03 | 1.11e-02 | 20 |
GO:00512592 | Esophagus | ESCC | protein complex oligomerization | 130/8552 | 238/18723 | 3.29e-03 | 1.36e-02 | 130 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:000697922 | Liver | HCC | response to oxidative stress | 281/7958 | 446/18723 | 9.75e-19 | 1.24e-16 | 281 |
GO:0008033 | Liver | HCC | tRNA processing | 87/7958 | 127/18723 | 2.66e-09 | 7.23e-08 | 87 |
GO:0006399 | Liver | HCC | tRNA metabolic process | 108/7958 | 179/18723 | 1.07e-06 | 1.59e-05 | 108 |
GO:0009451 | Liver | HCC | RNA modification | 101/7958 | 167/18723 | 2.02e-06 | 2.78e-05 | 101 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
THG1L | SNV | Missense_Mutation | novel | c.535G>A | p.Asp179Asn | p.D179N | Q9NWX6 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-C8-A8HQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
THG1L | SNV | Missense_Mutation | c.191N>C | p.Arg64Pro | p.R64P | Q9NWX6 | protein_coding | deleterious(0) | probably_damaging(0.949) | TCGA-E9-A1R5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
THG1L | insertion | Nonsense_Mutation | novel | c.616_617insTAACGCGGTAGCCAATGAGTGC | p.Gly206ValfsTer4 | p.G206Vfs*4 | Q9NWX6 | protein_coding | TCGA-A2-A0EM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
THG1L | SNV | Missense_Mutation | c.569N>C | p.Phe190Ser | p.F190S | Q9NWX6 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
THG1L | SNV | Missense_Mutation | novel | c.742N>A | p.Glu248Lys | p.E248K | Q9NWX6 | protein_coding | tolerated(0.07) | benign(0.332) | TCGA-IR-A3LL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
THG1L | SNV | Missense_Mutation | c.488N>G | p.Tyr163Cys | p.Y163C | Q9NWX6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
THG1L | SNV | Missense_Mutation | novel | c.697C>T | p.Pro233Ser | p.P233S | Q9NWX6 | protein_coding | tolerated(0.48) | benign(0.003) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
THG1L | SNV | Missense_Mutation | novel | c.83N>T | p.Ala28Val | p.A28V | Q9NWX6 | protein_coding | tolerated(0.27) | benign(0) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD |
THG1L | SNV | Missense_Mutation | rs201525305 | c.176G>A | p.Gly59Asp | p.G59D | Q9NWX6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-G4-6586-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
THG1L | deletion | Frame_Shift_Del | c.20_24delTTAAG | p.Val7GlyfsTer36 | p.V7Gfs*36 | Q9NWX6 | protein_coding | TCGA-CK-6747-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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