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Gene: TGFB1I1 |
Gene summary for TGFB1I1 |
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Gene information | Species | Human | Gene symbol | TGFB1I1 | Gene ID | 7041 |
Gene name | transforming growth factor beta 1 induced transcript 1 | |
Gene Alias | ARA55 | |
Cytomap | 16p11.2 | |
Gene Type | protein-coding | GO ID | GO:0001837 | UniProtAcc | O43294 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7041 | TGFB1I1 | NEOLP-3 | Human | Oral cavity | NEOLP | 3.34e-06 | 2.11e-01 | -0.0191 |
7041 | TGFB1I1 | SYSMH2 | Human | Oral cavity | OSCC | 1.14e-04 | 2.47e-01 | 0.2326 |
7041 | TGFB1I1 | male-WTA | Human | Thyroid | PTC | 8.96e-14 | 1.75e-01 | 0.1037 |
7041 | TGFB1I1 | PTC01 | Human | Thyroid | PTC | 2.99e-11 | 1.95e-01 | 0.1899 |
7041 | TGFB1I1 | PTC04 | Human | Thyroid | PTC | 2.42e-16 | 2.92e-01 | 0.1927 |
7041 | TGFB1I1 | PTC05 | Human | Thyroid | PTC | 1.04e-21 | 6.92e-01 | 0.2065 |
7041 | TGFB1I1 | PTC06 | Human | Thyroid | PTC | 3.45e-18 | 4.19e-01 | 0.2057 |
7041 | TGFB1I1 | PTC07 | Human | Thyroid | PTC | 1.17e-31 | 5.34e-01 | 0.2044 |
7041 | TGFB1I1 | ATC09 | Human | Thyroid | ATC | 1.12e-05 | 2.53e-01 | 0.2871 |
7041 | TGFB1I1 | ATC11 | Human | Thyroid | ATC | 3.39e-19 | 1.03e+00 | 0.3386 |
7041 | TGFB1I1 | ATC12 | Human | Thyroid | ATC | 8.91e-45 | 9.36e-01 | 0.34 |
7041 | TGFB1I1 | ATC13 | Human | Thyroid | ATC | 5.88e-57 | 1.20e+00 | 0.34 |
7041 | TGFB1I1 | ATC1 | Human | Thyroid | ATC | 1.52e-06 | 2.95e-01 | 0.2878 |
7041 | TGFB1I1 | ATC2 | Human | Thyroid | ATC | 3.39e-19 | 1.24e+00 | 0.34 |
7041 | TGFB1I1 | ATC3 | Human | Thyroid | ATC | 1.72e-22 | 9.00e-01 | 0.338 |
7041 | TGFB1I1 | ATC4 | Human | Thyroid | ATC | 4.30e-60 | 1.12e+00 | 0.34 |
7041 | TGFB1I1 | ATC5 | Human | Thyroid | ATC | 1.17e-53 | 1.29e+00 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001605517 | Esophagus | ESCC | Wnt signaling pathway | 268/8552 | 444/18723 | 2.32e-10 | 6.58e-09 | 268 |
GO:019873817 | Esophagus | ESCC | cell-cell signaling by wnt | 269/8552 | 446/18723 | 2.41e-10 | 6.79e-09 | 269 |
GO:0009408110 | Esophagus | ESCC | response to heat | 77/8552 | 110/18723 | 2.01e-07 | 3.11e-06 | 77 |
GO:00163316 | Esophagus | ESCC | morphogenesis of embryonic epithelium | 98/8552 | 147/18723 | 2.12e-07 | 3.27e-06 | 98 |
GO:00715599 | Esophagus | ESCC | response to transforming growth factor beta | 157/8552 | 256/18723 | 2.95e-07 | 4.23e-06 | 157 |
GO:00715609 | Esophagus | ESCC | cellular response to transforming growth factor beta stimulus | 151/8552 | 250/18723 | 1.78e-06 | 2.10e-05 | 151 |
GO:00107184 | Esophagus | ESCC | positive regulation of epithelial to mesenchymal transition | 40/8552 | 52/18723 | 4.25e-06 | 4.56e-05 | 40 |
GO:00071799 | Esophagus | ESCC | transforming growth factor beta receptor signaling pathway | 121/8552 | 198/18723 | 8.26e-06 | 8.03e-05 | 121 |
GO:00454449 | Esophagus | ESCC | fat cell differentiation | 135/8552 | 229/18723 | 3.38e-05 | 2.78e-04 | 135 |
GO:00018378 | Esophagus | ESCC | epithelial to mesenchymal transition | 95/8552 | 157/18723 | 1.25e-04 | 8.56e-04 | 95 |
GO:000926619 | Esophagus | ESCC | response to temperature stimulus | 106/8552 | 178/18723 | 1.30e-04 | 8.84e-04 | 106 |
GO:000717810 | Esophagus | ESCC | transmembrane receptor protein serine/threonine kinase signaling pathway | 195/8552 | 355/18723 | 2.58e-04 | 1.58e-03 | 195 |
GO:00487628 | Esophagus | ESCC | mesenchymal cell differentiation | 133/8552 | 236/18723 | 5.94e-04 | 3.22e-03 | 133 |
GO:00305115 | Esophagus | ESCC | positive regulation of transforming growth factor beta receptor signaling pathway | 24/8552 | 32/18723 | 7.22e-04 | 3.77e-03 | 24 |
GO:19038465 | Esophagus | ESCC | positive regulation of cellular response to transforming growth factor beta stimulus | 24/8552 | 32/18723 | 7.22e-04 | 3.77e-03 | 24 |
GO:00107174 | Esophagus | ESCC | regulation of epithelial to mesenchymal transition | 61/8552 | 99/18723 | 1.01e-03 | 5.09e-03 | 61 |
GO:00170156 | Esophagus | ESCC | regulation of transforming growth factor beta receptor signaling pathway | 75/8552 | 128/18723 | 2.19e-03 | 9.71e-03 | 75 |
GO:19038447 | Esophagus | ESCC | regulation of cellular response to transforming growth factor beta stimulus | 76/8552 | 131/18723 | 2.96e-03 | 1.24e-02 | 76 |
GO:00604856 | Esophagus | ESCC | mesenchyme development | 156/8552 | 291/18723 | 3.76e-03 | 1.53e-02 | 156 |
GO:00455984 | Esophagus | ESCC | regulation of fat cell differentiation | 79/8552 | 139/18723 | 5.23e-03 | 1.97e-02 | 79 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TGFB1I1 | SNV | Missense_Mutation | c.960N>G | p.Phe320Leu | p.F320L | O43294 | protein_coding | tolerated(0.06) | possibly_damaging(0.874) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TGFB1I1 | SNV | Missense_Mutation | novel | c.1232N>T | p.Pro411Leu | p.P411L | O43294 | protein_coding | deleterious(0) | probably_damaging(0.929) | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD |
TGFB1I1 | SNV | Missense_Mutation | c.661N>T | p.Pro221Ser | p.P221S | O43294 | protein_coding | tolerated(0.51) | benign(0.014) | TCGA-UC-A7PF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
TGFB1I1 | SNV | Missense_Mutation | rs199836545 | c.250G>A | p.Gly84Ser | p.G84S | O43294 | protein_coding | tolerated(0.72) | benign(0.011) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
TGFB1I1 | SNV | Missense_Mutation | rs201803234 | c.185N>T | p.Thr62Met | p.T62M | O43294 | protein_coding | tolerated(0.25) | probably_damaging(0.98) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TGFB1I1 | SNV | Missense_Mutation | novel | c.802N>A | p.Glu268Lys | p.E268K | O43294 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TGFB1I1 | SNV | Missense_Mutation | novel | c.338C>A | p.Ser113Tyr | p.S113Y | O43294 | protein_coding | deleterious(0.02) | probably_damaging(0.979) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
TGFB1I1 | SNV | Missense_Mutation | c.1182G>T | p.Glu394Asp | p.E394D | O43294 | protein_coding | deleterious(0.02) | possibly_damaging(0.893) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
TGFB1I1 | SNV | Missense_Mutation | rs753388681 | c.249N>A | p.Ser83Arg | p.S83R | O43294 | protein_coding | tolerated(0.06) | possibly_damaging(0.632) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
TGFB1I1 | SNV | Missense_Mutation | c.704T>A | p.Ile235Asn | p.I235N | O43294 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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