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Gene: STX17 |
Gene summary for STX17 |
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Gene information | Species | Human | Gene symbol | STX17 | Gene ID | 55014 |
Gene name | syntaxin 17 | |
Gene Alias | STX17 | |
Cytomap | 9q31.1 | |
Gene Type | protein-coding | GO ID | GO:0000045 | UniProtAcc | P56962 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55014 | STX17 | P91T-E | Human | Esophagus | ESCC | 1.39e-11 | 7.76e-01 | 0.1828 |
55014 | STX17 | P107T-E | Human | Esophagus | ESCC | 6.31e-44 | 9.48e-01 | 0.171 |
55014 | STX17 | P126T-E | Human | Esophagus | ESCC | 2.43e-05 | 3.93e-01 | 0.1125 |
55014 | STX17 | P127T-E | Human | Esophagus | ESCC | 2.06e-18 | 3.34e-01 | 0.0826 |
55014 | STX17 | P128T-E | Human | Esophagus | ESCC | 1.04e-11 | 4.46e-01 | 0.1241 |
55014 | STX17 | P130T-E | Human | Esophagus | ESCC | 5.57e-19 | 4.22e-01 | 0.1676 |
55014 | STX17 | HCC1_Meng | Human | Liver | HCC | 6.70e-28 | -8.43e-02 | 0.0246 |
55014 | STX17 | HCC2_Meng | Human | Liver | HCC | 7.19e-16 | 3.94e-02 | 0.0107 |
55014 | STX17 | HCC1 | Human | Liver | HCC | 1.67e-06 | 1.90e+00 | 0.5336 |
55014 | STX17 | HCC2 | Human | Liver | HCC | 2.29e-11 | 2.52e+00 | 0.5341 |
55014 | STX17 | HCC5 | Human | Liver | HCC | 3.45e-02 | 1.68e+00 | 0.4932 |
55014 | STX17 | S014 | Human | Liver | HCC | 8.44e-04 | 2.35e-01 | 0.2254 |
55014 | STX17 | S028 | Human | Liver | HCC | 7.19e-07 | 4.38e-01 | 0.2503 |
55014 | STX17 | S029 | Human | Liver | HCC | 9.97e-10 | 5.44e-01 | 0.2581 |
55014 | STX17 | C04 | Human | Oral cavity | OSCC | 1.89e-03 | 3.74e-01 | 0.2633 |
55014 | STX17 | C21 | Human | Oral cavity | OSCC | 9.07e-29 | 7.61e-01 | 0.2678 |
55014 | STX17 | C30 | Human | Oral cavity | OSCC | 8.94e-24 | 8.87e-01 | 0.3055 |
55014 | STX17 | C38 | Human | Oral cavity | OSCC | 1.79e-04 | 6.24e-01 | 0.172 |
55014 | STX17 | C43 | Human | Oral cavity | OSCC | 2.29e-02 | 1.25e-01 | 0.1704 |
55014 | STX17 | C46 | Human | Oral cavity | OSCC | 6.28e-13 | 3.40e-01 | 0.1673 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004819318 | Esophagus | ESCC | Golgi vesicle transport | 231/8552 | 296/18723 | 1.82e-30 | 9.63e-28 | 231 |
GO:001623617 | Esophagus | ESCC | macroautophagy | 216/8552 | 291/18723 | 1.94e-23 | 4.57e-21 | 216 |
GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
GO:001605014 | Esophagus | ESCC | vesicle organization | 211/8552 | 300/18723 | 2.85e-18 | 2.87e-16 | 211 |
GO:000688815 | Esophagus | ESCC | endoplasmic reticulum to Golgi vesicle-mediated transport | 102/8552 | 130/18723 | 1.73e-14 | 9.22e-13 | 102 |
GO:000703314 | Esophagus | ESCC | vacuole organization | 127/8552 | 180/18723 | 1.04e-11 | 3.85e-10 | 127 |
GO:003298416 | Esophagus | ESCC | protein-containing complex disassembly | 151/8552 | 224/18723 | 3.45e-11 | 1.15e-09 | 151 |
GO:190503712 | Esophagus | ESCC | autophagosome organization | 73/8552 | 103/18723 | 1.88e-07 | 2.93e-06 | 73 |
GO:00482844 | Esophagus | ESCC | organelle fusion | 94/8552 | 141/18723 | 3.72e-07 | 5.16e-06 | 94 |
GO:00224069 | Esophagus | ESCC | membrane docking | 62/8552 | 86/18723 | 5.93e-07 | 7.79e-06 | 62 |
GO:000004513 | Esophagus | ESCC | autophagosome assembly | 69/8552 | 99/18723 | 1.10e-06 | 1.38e-05 | 69 |
GO:00070308 | Esophagus | ESCC | Golgi organization | 101/8552 | 157/18723 | 1.78e-06 | 2.10e-05 | 101 |
GO:00901743 | Esophagus | ESCC | organelle membrane fusion | 73/8552 | 110/18723 | 9.29e-06 | 8.88e-05 | 73 |
GO:00069063 | Esophagus | ESCC | vesicle fusion | 70/8552 | 106/18723 | 1.82e-05 | 1.60e-04 | 70 |
GO:01400567 | Esophagus | ESCC | organelle localization by membrane tethering | 53/8552 | 77/18723 | 3.33e-05 | 2.74e-04 | 53 |
GO:00973523 | Esophagus | ESCC | autophagosome maturation | 31/8552 | 40/18723 | 4.04e-05 | 3.26e-04 | 31 |
GO:00610254 | Esophagus | ESCC | membrane fusion | 98/8552 | 163/18723 | 1.39e-04 | 9.41e-04 | 98 |
GO:00482781 | Esophagus | ESCC | vesicle docking | 38/8552 | 59/18723 | 2.86e-03 | 1.21e-02 | 38 |
GO:004819321 | Liver | HCC | Golgi vesicle transport | 217/7958 | 296/18723 | 2.58e-27 | 1.02e-24 | 217 |
GO:001623621 | Liver | HCC | macroautophagy | 204/7958 | 291/18723 | 8.66e-22 | 1.41e-19 | 204 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0414010 | Esophagus | ESCC | Autophagy - animal | 101/4205 | 141/8465 | 7.60e-08 | 6.21e-07 | 3.18e-07 | 101 |
hsa041305 | Esophagus | ESCC | SNARE interactions in vesicular transport | 28/4205 | 33/8465 | 2.75e-05 | 1.32e-04 | 6.75e-05 | 28 |
hsa0414015 | Esophagus | ESCC | Autophagy - animal | 101/4205 | 141/8465 | 7.60e-08 | 6.21e-07 | 3.18e-07 | 101 |
hsa0413012 | Esophagus | ESCC | SNARE interactions in vesicular transport | 28/4205 | 33/8465 | 2.75e-05 | 1.32e-04 | 6.75e-05 | 28 |
hsa0414021 | Liver | HCC | Autophagy - animal | 99/4020 | 141/8465 | 3.08e-08 | 4.70e-07 | 2.61e-07 | 99 |
hsa041302 | Liver | HCC | SNARE interactions in vesicular transport | 25/4020 | 33/8465 | 8.78e-04 | 3.38e-03 | 1.88e-03 | 25 |
hsa0414031 | Liver | HCC | Autophagy - animal | 99/4020 | 141/8465 | 3.08e-08 | 4.70e-07 | 2.61e-07 | 99 |
hsa041303 | Liver | HCC | SNARE interactions in vesicular transport | 25/4020 | 33/8465 | 8.78e-04 | 3.38e-03 | 1.88e-03 | 25 |
hsa041409 | Oral cavity | OSCC | Autophagy - animal | 94/3704 | 141/8465 | 2.73e-08 | 2.38e-07 | 1.21e-07 | 94 |
hsa041304 | Oral cavity | OSCC | SNARE interactions in vesicular transport | 28/3704 | 33/8465 | 1.31e-06 | 7.18e-06 | 3.66e-06 | 28 |
hsa0414014 | Oral cavity | OSCC | Autophagy - animal | 94/3704 | 141/8465 | 2.73e-08 | 2.38e-07 | 1.21e-07 | 94 |
hsa0413011 | Oral cavity | OSCC | SNARE interactions in vesicular transport | 28/3704 | 33/8465 | 1.31e-06 | 7.18e-06 | 3.66e-06 | 28 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STX17 | SNV | Missense_Mutation | novel | c.830N>T | p.Arg277Ile | p.R277I | P56962 | protein_coding | deleterious(0) | possibly_damaging(0.897) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STX17 | SNV | Missense_Mutation | novel | c.451N>G | p.Gln151Glu | p.Q151E | P56962 | protein_coding | tolerated(0.54) | benign(0) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD |
STX17 | SNV | Missense_Mutation | c.316N>G | p.Leu106Val | p.L106V | P56962 | protein_coding | tolerated(0.08) | benign(0.164) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
STX17 | SNV | Missense_Mutation | novel | c.112A>C | p.Asn38His | p.N38H | P56962 | protein_coding | deleterious(0.01) | probably_damaging(0.986) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
STX17 | SNV | Missense_Mutation | novel | c.760N>G | p.Lys254Glu | p.K254E | P56962 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
STX17 | SNV | Missense_Mutation | novel | c.648N>T | p.Glu216Asp | p.E216D | P56962 | protein_coding | tolerated(0.07) | possibly_damaging(0.824) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STX17 | SNV | Missense_Mutation | novel | c.812N>A | p.Gly271Asp | p.G271D | P56962 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STX17 | SNV | Missense_Mutation | novel | c.310N>A | p.Glu104Lys | p.E104K | P56962 | protein_coding | tolerated(0.3) | benign(0.006) | TCGA-AJ-A2QO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STX17 | SNV | Missense_Mutation | novel | c.779N>T | p.Ala260Val | p.A260V | P56962 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-AJ-A8CT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
STX17 | SNV | Missense_Mutation | novel | c.605N>A | p.Ser202Asn | p.S202N | P56962 | protein_coding | deleterious(0.03) | benign(0.13) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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