GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006913110 | Esophagus | ESCC | nucleocytoplasmic transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:0051169110 | Esophagus | ESCC | nuclear transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:0051168110 | Esophagus | ESCC | nuclear export | 126/8552 | 154/18723 | 1.88e-20 | 2.65e-18 | 126 |
GO:007190016 | Esophagus | ESCC | regulation of protein serine/threonine kinase activity | 227/8552 | 359/18723 | 1.12e-11 | 4.10e-10 | 227 |
GO:000661117 | Esophagus | ESCC | protein export from nucleus | 48/8552 | 57/18723 | 1.92e-09 | 4.39e-08 | 48 |
GO:00719029 | Esophagus | ESCC | positive regulation of protein serine/threonine kinase activity | 124/8552 | 200/18723 | 2.27e-06 | 2.61e-05 | 124 |
GO:004586018 | Esophagus | ESCC | positive regulation of protein kinase activity | 219/8552 | 386/18723 | 6.91e-06 | 6.97e-05 | 219 |
GO:003367420 | Esophagus | ESCC | positive regulation of kinase activity | 260/8552 | 467/18723 | 7.26e-06 | 7.22e-05 | 260 |
GO:00069138 | Lung | IAC | nucleocytoplasmic transport | 63/2061 | 301/18723 | 3.50e-07 | 2.54e-05 | 63 |
GO:00511698 | Lung | IAC | nuclear transport | 63/2061 | 301/18723 | 3.50e-07 | 2.54e-05 | 63 |
GO:00719006 | Lung | IAC | regulation of protein serine/threonine kinase activity | 71/2061 | 359/18723 | 6.33e-07 | 3.72e-05 | 71 |
GO:00511688 | Lung | IAC | nuclear export | 38/2061 | 154/18723 | 1.24e-06 | 6.45e-05 | 38 |
GO:00458607 | Lung | IAC | positive regulation of protein kinase activity | 72/2061 | 386/18723 | 4.89e-06 | 1.96e-04 | 72 |
GO:00719024 | Lung | IAC | positive regulation of protein serine/threonine kinase activity | 44/2061 | 200/18723 | 5.16e-06 | 2.04e-04 | 44 |
GO:00336748 | Lung | IAC | positive regulation of kinase activity | 83/2061 | 467/18723 | 6.76e-06 | 2.45e-04 | 83 |
GO:00066115 | Lung | IAC | protein export from nucleus | 14/2061 | 57/18723 | 2.93e-03 | 2.61e-02 | 14 |
GO:005116823 | Lung | MIAC | nuclear export | 18/967 | 154/18723 | 1.01e-03 | 2.07e-02 | 18 |
GO:003367431 | Lung | MIAC | positive regulation of kinase activity | 40/967 | 467/18723 | 1.22e-03 | 2.31e-02 | 40 |
GO:000661122 | Lung | MIAC | protein export from nucleus | 9/967 | 57/18723 | 2.43e-03 | 3.56e-02 | 9 |
GO:004586022 | Lung | MIAC | positive regulation of protein kinase activity | 33/967 | 386/18723 | 3.24e-03 | 4.27e-02 | 33 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STRADA | SNV | Missense_Mutation | novel | c.1012N>T | p.Asp338Tyr | p.D338Y | Q7RTN6 | protein_coding | deleterious(0) | possibly_damaging(0.652) | TCGA-A2-A04P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | PD |
STRADA | SNV | Missense_Mutation | | c.497N>A | p.Gly166Asp | p.G166D | Q7RTN6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD |
STRADA | SNV | Missense_Mutation | novel | c.676N>G | p.Arg226Gly | p.R226G | Q7RTN6 | protein_coding | deleterious(0.01) | probably_damaging(0.98) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
STRADA | SNV | Missense_Mutation | | c.388N>G | p.Ile130Val | p.I130V | Q7RTN6 | protein_coding | tolerated(0.12) | benign(0.116) | TCGA-E9-A228-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
STRADA | insertion | Frame_Shift_Ins | novel | c.143_144insCCCCA | p.Glu48AspfsTer5 | p.E48Dfs*5 | Q7RTN6 | protein_coding | | | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STRADA | insertion | Nonsense_Mutation | novel | c.141_142insTAGTAGGGAAAATGGTAAAACTG | p.Glu48Ter | p.E48* | Q7RTN6 | protein_coding | | | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STRADA | insertion | Nonsense_Mutation | novel | c.465_466insGGGGCCCAGGGAAGTCCTGGGAGGAGGCAGCCTTGAG | p.Lys156GlyfsTer12 | p.K156Gfs*12 | Q7RTN6 | protein_coding | | | TCGA-AO-A03T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
STRADA | insertion | Nonsense_Mutation | novel | c.249_250insCCCAGTCCTGACATTCCTTTCTATTCGAGAAGCAAGTAGC | p.Thr84ProfsTer13 | p.T84Pfs*13 | Q7RTN6 | protein_coding | | | TCGA-BH-A0DZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
STRADA | deletion | Frame_Shift_Del | novel | c.44delN | p.Val15AlafsTer10 | p.V15Afs*10 | Q7RTN6 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
STRADA | SNV | Missense_Mutation | novel | c.328N>C | p.Glu110Gln | p.E110Q | Q7RTN6 | protein_coding | deleterious(0.05) | probably_damaging(0.931) | TCGA-C5-A8XJ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | SD |