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Gene: SPNS1 |
Gene summary for SPNS1 |
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Gene information | Species | Human | Gene symbol | SPNS1 | Gene ID | 83985 |
Gene name | sphingolipid transporter 1 (putative) | |
Gene Alias | HSpin1 | |
Cytomap | 16p11.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9H2V7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83985 | SPNS1 | P84T-E | Human | Esophagus | ESCC | 8.88e-27 | 8.15e-01 | 0.0933 |
83985 | SPNS1 | P89T-E | Human | Esophagus | ESCC | 6.52e-33 | 1.35e+00 | 0.1752 |
83985 | SPNS1 | P91T-E | Human | Esophagus | ESCC | 1.69e-27 | 1.57e+00 | 0.1828 |
83985 | SPNS1 | P94T-E | Human | Esophagus | ESCC | 6.09e-07 | 7.50e-01 | 0.0879 |
83985 | SPNS1 | P104T-E | Human | Esophagus | ESCC | 2.06e-06 | 5.92e-01 | 0.0931 |
83985 | SPNS1 | P107T-E | Human | Esophagus | ESCC | 8.55e-59 | 1.19e+00 | 0.171 |
83985 | SPNS1 | P126T-E | Human | Esophagus | ESCC | 2.15e-17 | 9.02e-01 | 0.1125 |
83985 | SPNS1 | P127T-E | Human | Esophagus | ESCC | 7.08e-25 | 4.46e-01 | 0.0826 |
83985 | SPNS1 | P128T-E | Human | Esophagus | ESCC | 2.50e-50 | 1.08e+00 | 0.1241 |
83985 | SPNS1 | P130T-E | Human | Esophagus | ESCC | 7.71e-74 | 1.23e+00 | 0.1676 |
83985 | SPNS1 | HCC1_Meng | Human | Liver | HCC | 3.45e-61 | 9.12e-02 | 0.0246 |
83985 | SPNS1 | HCC2_Meng | Human | Liver | HCC | 7.50e-19 | 6.20e-02 | 0.0107 |
83985 | SPNS1 | cirrhotic1 | Human | Liver | Cirrhotic | 1.15e-04 | 1.78e-01 | 0.0202 |
83985 | SPNS1 | cirrhotic2 | Human | Liver | Cirrhotic | 2.85e-02 | 1.14e-01 | 0.0201 |
83985 | SPNS1 | HCC1 | Human | Liver | HCC | 4.62e-16 | 3.52e+00 | 0.5336 |
83985 | SPNS1 | HCC2 | Human | Liver | HCC | 2.33e-16 | 2.82e+00 | 0.5341 |
83985 | SPNS1 | Pt13.b | Human | Liver | HCC | 1.32e-11 | 1.93e-01 | 0.0251 |
83985 | SPNS1 | Pt14.b | Human | Liver | HCC | 1.50e-04 | 2.70e-01 | 0.018 |
83985 | SPNS1 | S014 | Human | Liver | HCC | 3.25e-37 | 1.28e+00 | 0.2254 |
83985 | SPNS1 | S015 | Human | Liver | HCC | 3.58e-31 | 1.35e+00 | 0.2375 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001087611 | Liver | Cirrhotic | lipid localization | 147/4634 | 448/18723 | 6.24e-05 | 7.12e-04 | 147 |
GO:000686911 | Liver | Cirrhotic | lipid transport | 128/4634 | 398/18723 | 4.54e-04 | 3.69e-03 | 128 |
GO:001087621 | Liver | HCC | lipid localization | 228/7958 | 448/18723 | 1.80e-04 | 1.41e-03 | 228 |
GO:000686921 | Liver | HCC | lipid transport | 198/7958 | 398/18723 | 1.92e-03 | 9.78e-03 | 198 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SPNS1 | SNV | Missense_Mutation | c.47C>G | p.Pro16Arg | p.P16R | Q9H2V7 | protein_coding | tolerated(0.52) | benign(0.026) | TCGA-A2-A0CU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
SPNS1 | SNV | Missense_Mutation | c.112N>A | p.Glu38Lys | p.E38K | Q9H2V7 | protein_coding | tolerated(0.71) | benign(0.001) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SPNS1 | SNV | Missense_Mutation | novel | c.919G>A | p.Glu307Lys | p.E307K | Q9H2V7 | protein_coding | tolerated(0.8) | benign(0.01) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SPNS1 | SNV | Missense_Mutation | novel | c.796N>T | p.Ala266Ser | p.A266S | Q9H2V7 | protein_coding | tolerated(0.5) | benign(0.034) | TCGA-BH-A0HQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
SPNS1 | SNV | Missense_Mutation | novel | c.796N>T | p.Ala266Ser | p.A266S | Q9H2V7 | protein_coding | tolerated(0.5) | benign(0.034) | TCGA-C8-A274-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
SPNS1 | SNV | Missense_Mutation | novel | c.531N>A | p.Asp177Glu | p.D177E | Q9H2V7 | protein_coding | deleterious(0) | probably_damaging(0.956) | TCGA-LL-A6FP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
SPNS1 | deletion | Frame_Shift_Del | novel | c.127delG | p.Asp43ThrfsTer19 | p.D43Tfs*19 | Q9H2V7 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
SPNS1 | SNV | Missense_Mutation | novel | c.878G>T | p.Trp293Leu | p.W293L | Q9H2V7 | protein_coding | deleterious(0.02) | probably_damaging(0.957) | TCGA-C5-A8YT-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
SPNS1 | SNV | Missense_Mutation | novel | c.1207N>A | p.Ala403Thr | p.A403T | Q9H2V7 | protein_coding | tolerated(0.18) | benign(0.241) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SPNS1 | SNV | Missense_Mutation | rs766964284 | c.561N>A | p.Met187Ile | p.M187I | Q9H2V7 | protein_coding | deleterious(0) | possibly_damaging(0.449) | TCGA-EX-A1H6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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