![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SPATA6 |
Gene summary for SPATA6 |
![]() |
Gene information | Species | Human | Gene symbol | SPATA6 | Gene ID | 54558 |
Gene name | spermatogenesis associated 6 | |
Gene Alias | HASH | |
Cytomap | 1p33 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9NWH7 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54558 | SPATA6 | PTC03 | Human | Thyroid | PTC | 1.59e-02 | 1.06e-01 | 0.1784 |
54558 | SPATA6 | PTC04 | Human | Thyroid | PTC | 5.51e-15 | 2.14e-01 | 0.1927 |
54558 | SPATA6 | PTC05 | Human | Thyroid | PTC | 1.45e-14 | 4.05e-01 | 0.2065 |
54558 | SPATA6 | PTC06 | Human | Thyroid | PTC | 2.60e-15 | 3.37e-01 | 0.2057 |
54558 | SPATA6 | PTC07 | Human | Thyroid | PTC | 1.98e-27 | 3.49e-01 | 0.2044 |
54558 | SPATA6 | ATC12 | Human | Thyroid | ATC | 4.23e-07 | 3.67e-02 | 0.34 |
54558 | SPATA6 | ATC13 | Human | Thyroid | ATC | 2.28e-38 | 6.36e-01 | 0.34 |
54558 | SPATA6 | ATC4 | Human | Thyroid | ATC | 3.37e-06 | 6.48e-02 | 0.34 |
54558 | SPATA6 | ATC5 | Human | Thyroid | ATC | 2.76e-39 | 6.87e-01 | 0.34 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0060271 | Lung | IAC | cilium assembly | 55/2061 | 337/18723 | 1.84e-03 | 1.88e-02 | 55 |
GO:0044782 | Lung | IAC | cilium organization | 58/2061 | 368/18723 | 3.15e-03 | 2.75e-02 | 58 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SPATA6 | SNV | Missense_Mutation | c.1378N>A | p.Pro460Thr | p.P460T | Q9NWH7 | protein_coding | deleterious(0.02) | probably_damaging(0.992) | TCGA-A8-A09Q-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD | |
SPATA6 | SNV | Missense_Mutation | c.638N>T | p.Ser213Leu | p.S213L | Q9NWH7 | protein_coding | deleterious(0) | probably_damaging(0.946) | TCGA-BH-A0W7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
SPATA6 | deletion | Frame_Shift_Del | c.135delA | p.Gln45HisfsTer25 | p.Q45Hfs*25 | Q9NWH7 | protein_coding | TCGA-BH-A208-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
SPATA6 | SNV | Missense_Mutation | novel | c.1355N>T | p.Ser452Phe | p.S452F | Q9NWH7 | protein_coding | deleterious(0.05) | benign(0.269) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
SPATA6 | SNV | Missense_Mutation | c.97C>T | p.Leu33Phe | p.L33F | Q9NWH7 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-EK-A2RK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
SPATA6 | SNV | Missense_Mutation | c.107G>C | p.Cys36Ser | p.C36S | Q9NWH7 | protein_coding | tolerated(0.54) | possibly_damaging(0.891) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SPATA6 | SNV | Missense_Mutation | rs377106164 | c.674G>A | p.Arg225His | p.R225H | Q9NWH7 | protein_coding | tolerated(0.11) | probably_damaging(0.984) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
SPATA6 | SNV | Missense_Mutation | rs201878636 | c.983N>T | p.Ser328Leu | p.S328L | Q9NWH7 | protein_coding | tolerated(0.73) | benign(0.053) | TCGA-CK-6751-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SPATA6 | SNV | Missense_Mutation | rs755315175 | c.1279G>A | p.Glu427Lys | p.E427K | Q9NWH7 | protein_coding | tolerated(0.17) | probably_damaging(0.955) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SPATA6 | SNV | Missense_Mutation | novel | c.538C>A | p.Gln180Lys | p.Q180K | Q9NWH7 | protein_coding | tolerated(0.2) | benign(0.015) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |