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Gene: SNX7 |
Gene summary for SNX7 |
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Gene information | Species | Human | Gene symbol | SNX7 | Gene ID | 51375 |
Gene name | sorting nexin 7 | |
Gene Alias | SNX7 | |
Cytomap | 1p21.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9UNH6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51375 | SNX7 | C43 | Human | Oral cavity | OSCC | 1.50e-27 | 6.52e-01 | 0.1704 |
51375 | SNX7 | C46 | Human | Oral cavity | OSCC | 1.72e-34 | 8.30e-01 | 0.1673 |
51375 | SNX7 | C51 | Human | Oral cavity | OSCC | 1.07e-10 | 6.69e-01 | 0.2674 |
51375 | SNX7 | C06 | Human | Oral cavity | OSCC | 1.71e-16 | 1.28e+00 | 0.2699 |
51375 | SNX7 | C08 | Human | Oral cavity | OSCC | 1.29e-11 | 4.23e-01 | 0.1919 |
51375 | SNX7 | C09 | Human | Oral cavity | OSCC | 2.26e-08 | 2.75e-01 | 0.1431 |
51375 | SNX7 | LN46 | Human | Oral cavity | OSCC | 1.72e-16 | 7.96e-01 | 0.1666 |
51375 | SNX7 | LP15 | Human | Oral cavity | LP | 4.77e-06 | 1.25e+00 | 0.2174 |
51375 | SNX7 | LP17 | Human | Oral cavity | LP | 9.82e-04 | 7.06e-01 | 0.2349 |
51375 | SNX7 | SYSMH2 | Human | Oral cavity | OSCC | 1.51e-11 | 4.98e-01 | 0.2326 |
51375 | SNX7 | SYSMH3 | Human | Oral cavity | OSCC | 1.38e-05 | 2.97e-01 | 0.2442 |
51375 | SNX7 | P10_cSCC | Human | Skin | cSCC | 4.83e-17 | 9.57e-01 | 0.1017 |
51375 | SNX7 | cSCC_p7 | Human | Skin | cSCC | 2.43e-02 | -2.04e-01 | -0.2332 |
51375 | SNX7 | male-WTA | Human | Thyroid | PTC | 9.98e-05 | 5.49e-02 | 0.1037 |
51375 | SNX7 | PTC01 | Human | Thyroid | PTC | 1.28e-04 | 9.85e-02 | 0.1899 |
51375 | SNX7 | PTC04 | Human | Thyroid | PTC | 4.02e-06 | 8.58e-02 | 0.1927 |
51375 | SNX7 | PTC05 | Human | Thyroid | PTC | 4.06e-13 | 3.69e-01 | 0.2065 |
51375 | SNX7 | PTC06 | Human | Thyroid | PTC | 1.25e-13 | 3.09e-01 | 0.2057 |
51375 | SNX7 | PTC07 | Human | Thyroid | PTC | 1.85e-16 | 2.76e-01 | 0.2044 |
51375 | SNX7 | ATC09 | Human | Thyroid | ATC | 4.53e-07 | 2.09e-01 | 0.2871 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SNX7 | SNV | Missense_Mutation | novel | c.850N>A | p.Glu284Lys | p.E284K | Q9UNH6 | protein_coding | deleterious(0) | probably_damaging(0.948) | TCGA-BH-A0EE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | SD |
SNX7 | SNV | Missense_Mutation | c.291C>A | p.Phe97Leu | p.F97L | Q9UNH6 | protein_coding | tolerated(0.09) | benign(0.062) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SNX7 | SNV | Missense_Mutation | c.287N>C | p.Leu96Pro | p.L96P | Q9UNH6 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-E2-A1LL-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | docetaxel | PD | |
SNX7 | SNV | Missense_Mutation | rs373801140 | c.514N>T | p.Arg172Cys | p.R172C | Q9UNH6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EW-A1IZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | SD |
SNX7 | SNV | Missense_Mutation | c.607G>C | p.Asp203His | p.D203H | Q9UNH6 | protein_coding | tolerated(0.85) | benign(0.024) | TCGA-GI-A2C8-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | Adriamycin | SD | |
SNX7 | SNV | Missense_Mutation | c.339N>A | p.Phe113Leu | p.F113L | Q9UNH6 | protein_coding | deleterious(0.01) | possibly_damaging(0.739) | TCGA-AA-3693-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
SNX7 | SNV | Missense_Mutation | c.190N>A | p.Leu64Met | p.L64M | Q9UNH6 | protein_coding | deleterious_low_confidence(0.05) | probably_damaging(0.976) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
SNX7 | SNV | Missense_Mutation | c.134N>C | p.Val45Ala | p.V45A | Q9UNH6 | protein_coding | tolerated_low_confidence(0.77) | probably_damaging(0.971) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD | |
SNX7 | SNV | Missense_Mutation | c.1130N>T | p.Pro377Leu | p.P377L | Q9UNH6 | protein_coding | tolerated(0.06) | benign(0.003) | TCGA-DY-A1DD-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
SNX7 | SNV | Missense_Mutation | novel | c.333N>C | p.Glu111Asp | p.E111D | Q9UNH6 | protein_coding | deleterious(0.03) | benign(0.283) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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