![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SNX27 |
Gene summary for SNX27 |
![]() |
Gene information | Species | Human | Gene symbol | SNX27 | Gene ID | 81609 |
Gene name | sorting nexin 27 | |
Gene Alias | MRT1 | |
Cytomap | 1q21.3 | |
Gene Type | protein-coding | GO ID | GO:0001767 | UniProtAcc | Q96L92 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81609 | SNX27 | P130T-E | Human | Esophagus | ESCC | 8.07e-47 | 8.40e-01 | 0.1676 |
81609 | SNX27 | HCC1_Meng | Human | Liver | HCC | 3.32e-47 | 1.72e-02 | 0.0246 |
81609 | SNX27 | HCC2_Meng | Human | Liver | HCC | 4.58e-14 | 7.63e-02 | 0.0107 |
81609 | SNX27 | HCC1 | Human | Liver | HCC | 1.92e-03 | 2.89e+00 | 0.5336 |
81609 | SNX27 | HCC2 | Human | Liver | HCC | 4.27e-18 | 4.04e+00 | 0.5341 |
81609 | SNX27 | Pt13.b | Human | Liver | HCC | 1.45e-07 | 9.23e-02 | 0.0251 |
81609 | SNX27 | S014 | Human | Liver | HCC | 3.66e-10 | 5.52e-01 | 0.2254 |
81609 | SNX27 | S015 | Human | Liver | HCC | 3.98e-07 | 5.62e-01 | 0.2375 |
81609 | SNX27 | S016 | Human | Liver | HCC | 3.48e-14 | 5.83e-01 | 0.2243 |
81609 | SNX27 | S027 | Human | Liver | HCC | 5.55e-06 | 7.70e-01 | 0.2446 |
81609 | SNX27 | S028 | Human | Liver | HCC | 1.30e-17 | 8.58e-01 | 0.2503 |
81609 | SNX27 | S029 | Human | Liver | HCC | 2.44e-20 | 1.01e+00 | 0.2581 |
81609 | SNX27 | C04 | Human | Oral cavity | OSCC | 3.41e-07 | 4.70e-01 | 0.2633 |
81609 | SNX27 | C21 | Human | Oral cavity | OSCC | 3.04e-15 | 5.32e-01 | 0.2678 |
81609 | SNX27 | C30 | Human | Oral cavity | OSCC | 1.09e-20 | 8.23e-01 | 0.3055 |
81609 | SNX27 | C38 | Human | Oral cavity | OSCC | 1.82e-04 | 5.17e-01 | 0.172 |
81609 | SNX27 | C43 | Human | Oral cavity | OSCC | 1.65e-12 | 1.63e-01 | 0.1704 |
81609 | SNX27 | C46 | Human | Oral cavity | OSCC | 6.45e-06 | 2.54e-01 | 0.1673 |
81609 | SNX27 | C51 | Human | Oral cavity | OSCC | 7.29e-07 | 5.01e-01 | 0.2674 |
81609 | SNX27 | C57 | Human | Oral cavity | OSCC | 4.27e-03 | 1.55e-01 | 0.1679 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001619715 | Esophagus | ESCC | endosomal transport | 168/8552 | 230/18723 | 2.28e-17 | 1.93e-15 | 168 |
GO:000703417 | Esophagus | ESCC | vacuolar transport | 119/8552 | 157/18723 | 1.16e-14 | 6.30e-13 | 119 |
GO:009887615 | Esophagus | ESCC | vesicle-mediated transport to the plasma membrane | 99/8552 | 136/18723 | 1.13e-10 | 3.39e-09 | 99 |
GO:000716320 | Esophagus | ESCC | establishment or maintenance of cell polarity | 143/8552 | 218/18723 | 2.05e-09 | 4.65e-08 | 143 |
GO:00070419 | Esophagus | ESCC | lysosomal transport | 83/8552 | 114/18723 | 3.52e-09 | 7.41e-08 | 83 |
GO:003001018 | Esophagus | ESCC | establishment of cell polarity | 96/8552 | 143/18723 | 1.69e-07 | 2.67e-06 | 96 |
GO:00324565 | Esophagus | ESCC | endocytic recycling | 51/8552 | 73/18723 | 2.47e-05 | 2.10e-04 | 51 |
GO:00083333 | Esophagus | ESCC | endosome to lysosome transport | 40/8552 | 55/18723 | 4.27e-05 | 3.42e-04 | 40 |
GO:001619721 | Liver | HCC | endosomal transport | 154/7958 | 230/18723 | 4.74e-14 | 2.95e-12 | 154 |
GO:000703421 | Liver | HCC | vacuolar transport | 108/7958 | 157/18723 | 2.22e-11 | 8.69e-10 | 108 |
GO:009887621 | Liver | HCC | vesicle-mediated transport to the plasma membrane | 92/7958 | 136/18723 | 2.57e-09 | 7.07e-08 | 92 |
GO:000716322 | Liver | HCC | establishment or maintenance of cell polarity | 133/7958 | 218/18723 | 2.48e-08 | 5.73e-07 | 133 |
GO:000704121 | Liver | HCC | lysosomal transport | 76/7958 | 114/18723 | 1.56e-07 | 2.88e-06 | 76 |
GO:00324562 | Liver | HCC | endocytic recycling | 48/7958 | 73/18723 | 5.07e-05 | 4.83e-04 | 48 |
GO:003001022 | Liver | HCC | establishment of cell polarity | 82/7958 | 143/18723 | 2.38e-04 | 1.79e-03 | 82 |
GO:00083331 | Liver | HCC | endosome to lysosome transport | 35/7958 | 55/18723 | 1.26e-03 | 6.92e-03 | 35 |
GO:00161979 | Oral cavity | OSCC | endosomal transport | 141/7305 | 230/18723 | 5.40e-12 | 2.06e-10 | 141 |
GO:000703410 | Oral cavity | OSCC | vacuolar transport | 103/7305 | 157/18723 | 1.25e-11 | 4.44e-10 | 103 |
GO:000716318 | Oral cavity | OSCC | establishment or maintenance of cell polarity | 129/7305 | 218/18723 | 1.16e-09 | 2.86e-08 | 129 |
GO:00070418 | Oral cavity | OSCC | lysosomal transport | 69/7305 | 114/18723 | 2.62e-06 | 3.26e-05 | 69 |
Page: 1 2 3 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SNX27 | SNV | Missense_Mutation | novel | c.1045N>T | p.Ala349Ser | p.A349S | Q96L92 | protein_coding | tolerated(0.1) | possibly_damaging(0.802) | TCGA-A2-A0YK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
SNX27 | SNV | Missense_Mutation | novel | c.320N>G | p.Val107Gly | p.V107G | Q96L92 | protein_coding | deleterious(0.01) | benign(0.188) | TCGA-OL-A97C-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SNX27 | SNV | Missense_Mutation | novel | c.1095A>C | p.Glu365Asp | p.E365D | Q96L92 | protein_coding | tolerated(0.55) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SNX27 | SNV | Missense_Mutation | c.1303N>C | p.Asp435His | p.D435H | Q96L92 | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD | |
SNX27 | SNV | Missense_Mutation | novel | c.707N>A | p.Arg236His | p.R236H | Q96L92 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SNX27 | SNV | Missense_Mutation | c.1043N>T | p.Ser348Leu | p.S348L | Q96L92 | protein_coding | deleterious(0) | benign(0.331) | TCGA-EA-A43B-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
SNX27 | SNV | Missense_Mutation | c.466N>A | p.Asp156Asn | p.D156N | Q96L92 | protein_coding | deleterious(0) | possibly_damaging(0.614) | TCGA-JW-A852-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
SNX27 | SNV | Missense_Mutation | c.418N>A | p.Ala140Thr | p.A140T | Q96L92 | protein_coding | deleterious(0.03) | benign(0.072) | TCGA-AA-3833-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SNX27 | SNV | Missense_Mutation | rs752336635 | c.373G>A | p.Glu125Lys | p.E125K | Q96L92 | protein_coding | tolerated(0.13) | benign(0.017) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SNX27 | SNV | Missense_Mutation | c.1524N>A | p.Asn508Lys | p.N508K | Q96L92 | protein_coding | tolerated(0.85) | benign(0.003) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |