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Gene: SNHG19 |
Gene summary for SNHG19 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | SNHG19 | Gene ID | 100507303 |
| Gene name | small nucleolar RNA host gene 19 | |
| Gene Alias | SNORD60HG | |
| Cytomap | 16p13.3 | |
| Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 100507303 | SNHG19 | GSM5353223_PA_PB2B_Pool_2_S26_L001 | Human | Prostate | Tumor | 1.44e-02 | -3.19e-01 | 0.1604 |
| 100507303 | SNHG19 | GSM5353224_PA_PR5186_Pool_1_2_3_S27_L001 | Human | Prostate | Tumor | 5.75e-03 | -3.19e-01 | 0.1621 |
| 100507303 | SNHG19 | GSM5353227_PA_PR5199-193K_Pool_1_2_3_S55_L002 | Human | Prostate | Tumor | 7.97e-04 | -3.19e-01 | 0.1602 |
| 100507303 | SNHG19 | GSM5353240_PA_PR5254_T1_S15_L001 | Human | Prostate | Tumor | 2.51e-07 | -3.19e-01 | 0.1575 |
| 100507303 | SNHG19 | GSM5353243_PA_PR5261_T1_S23_L002 | Human | Prostate | Tumor | 2.60e-08 | -3.19e-01 | 0.1545 |
| 100507303 | SNHG19 | GSM5353244_PA_PR5261_T2_S24_L002 | Human | Prostate | Tumor | 8.17e-06 | -3.19e-01 | 0.1569 |
| 100507303 | SNHG19 | Adj_PTCwithHT_6 | Human | Thyroid | HT | 6.54e-03 | -2.51e-01 | 0.02 |
| 100507303 | SNHG19 | PTCwithHT_6 | Human | Thyroid | HT | 4.12e-02 | -2.63e-01 | 0.02 |
| 100507303 | SNHG19 | PTCwithoutHT_2 | Human | Thyroid | PTC | 3.22e-03 | -2.58e-01 | 0.0419 |
| 100507303 | SNHG19 | male-WTA | Human | Thyroid | PTC | 2.42e-55 | 3.62e-01 | 0.1037 |
| 100507303 | SNHG19 | PTC01 | Human | Thyroid | PTC | 6.29e-15 | 4.41e-01 | 0.1899 |
| 100507303 | SNHG19 | PTC04 | Human | Thyroid | PTC | 9.70e-05 | 8.58e-02 | 0.1927 |
| 100507303 | SNHG19 | PTC05 | Human | Thyroid | PTC | 7.11e-05 | 5.11e-01 | 0.2065 |
| 100507303 | SNHG19 | PTC06 | Human | Thyroid | PTC | 1.08e-41 | 1.43e+00 | 0.2057 |
| 100507303 | SNHG19 | PTC07 | Human | Thyroid | PTC | 7.37e-76 | 1.78e+00 | 0.2044 |
| 100507303 | SNHG19 | ATC12 | Human | Thyroid | ATC | 1.37e-13 | -3.42e-02 | 0.34 |
| 100507303 | SNHG19 | ATC13 | Human | Thyroid | ATC | 2.11e-10 | -1.23e-01 | 0.34 |
| 100507303 | SNHG19 | ATC4 | Human | Thyroid | ATC | 4.04e-08 | 5.17e-02 | 0.34 |
| 100507303 | SNHG19 | ATC5 | Human | Thyroid | ATC | 2.72e-05 | -1.20e-01 | 0.34 |
| Page: 1 2 3 4 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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