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Gene: SLC35E2B |
Gene summary for SLC35E2B |
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Gene information | Species | Human | Gene symbol | SLC35E2B | Gene ID | 728661 |
Gene name | solute carrier family 35 member E2B | |
Gene Alias | SLC35E2 | |
Cytomap | 1p36.33 | |
Gene Type | protein-coding | GO ID | GO:0001701 | UniProtAcc | P0CK96 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
728661 | SLC35E2B | C46 | Human | Oral cavity | OSCC | 1.76e-10 | 2.87e-01 | 0.1673 |
728661 | SLC35E2B | C51 | Human | Oral cavity | OSCC | 2.30e-05 | 3.24e-01 | 0.2674 |
728661 | SLC35E2B | C07 | Human | Oral cavity | OSCC | 5.00e-06 | 5.01e-01 | 0.2491 |
728661 | SLC35E2B | C08 | Human | Oral cavity | OSCC | 1.00e-03 | 1.80e-01 | 0.1919 |
728661 | SLC35E2B | LN46 | Human | Oral cavity | OSCC | 2.37e-02 | 1.83e-01 | 0.1666 |
728661 | SLC35E2B | SYSMH2 | Human | Oral cavity | OSCC | 6.33e-06 | 2.09e-01 | 0.2326 |
728661 | SLC35E2B | SYSMH3 | Human | Oral cavity | OSCC | 3.98e-08 | 2.72e-01 | 0.2442 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0001701 | Colorectum | AD | in utero embryonic development | 110/3918 | 367/18723 | 2.36e-05 | 4.62e-04 | 110 |
GO:00017012 | Colorectum | MSS | in utero embryonic development | 99/3467 | 367/18723 | 3.71e-05 | 7.10e-04 | 99 |
GO:00017013 | Colorectum | FAP | in utero embryonic development | 81/2622 | 367/18723 | 1.58e-05 | 4.10e-04 | 81 |
GO:000170119 | Esophagus | ESCC | in utero embryonic development | 243/8552 | 367/18723 | 1.00e-15 | 6.86e-14 | 243 |
GO:000182412 | Esophagus | ESCC | blastocyst development | 73/8552 | 106/18723 | 1.13e-06 | 1.40e-05 | 73 |
GO:000170116 | Oral cavity | OSCC | in utero embryonic development | 207/7305 | 367/18723 | 7.92e-12 | 2.95e-10 | 207 |
GO:00018243 | Oral cavity | OSCC | blastocyst development | 66/7305 | 106/18723 | 1.04e-06 | 1.40e-05 | 66 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC35E2B | SNV | Missense_Mutation | novel | c.901C>G | p.Leu301Val | p.L301V | P0CK96 | protein_coding | tolerated(0.15) | benign(0.036) | TCGA-A2-A0CR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
SLC35E2B | SNV | Missense_Mutation | novel | c.771N>T | p.Glu257Asp | p.E257D | P0CK96 | protein_coding | deleterious(0.04) | possibly_damaging(0.794) | TCGA-PL-A8LZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
SLC35E2B | insertion | Frame_Shift_Ins | novel | c.654_655insGGTGT | p.Ser219GlyfsTer66 | p.S219Gfs*66 | P0CK96 | protein_coding | TCGA-A8-A06Q-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
SLC35E2B | insertion | Frame_Shift_Ins | novel | c.653_654insACGCTCAGCAGTGTGTCTCGCT | p.Ser219ArgfsTer207 | p.S219Rfs*207 | P0CK96 | protein_coding | TCGA-A8-A06Q-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
SLC35E2B | insertion | Frame_Shift_Ins | novel | c.717_718insCC | p.Val240ProfsTer44 | p.V240Pfs*44 | P0CK96 | protein_coding | TCGA-AN-A0FK-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
SLC35E2B | insertion | In_Frame_Ins | novel | c.716_717insGGGTCTCCTGCTGCCACGGTGGGCACTCAGAACTTC | p.Asn239delinsLysGlyLeuLeuLeuProArgTrpAlaLeuArgThrSer | p.N239delinsKGLLLPRWALRTS | P0CK96 | protein_coding | TCGA-AN-A0FK-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
SLC35E2B | SNV | Missense_Mutation | novel | c.725N>T | p.Ser242Leu | p.S242L | P0CK96 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-DS-A7WH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SLC35E2B | SNV | Missense_Mutation | rs756610571 | c.521C>T | p.Thr174Met | p.T174M | P0CK96 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-ZJ-AB0H-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
SLC35E2B | SNV | Missense_Mutation | rs762246071 | c.835N>T | p.Asp279Tyr | p.D279Y | P0CK96 | protein_coding | deleterious(0.01) | probably_damaging(0.984) | TCGA-A6-5667-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
SLC35E2B | SNV | Missense_Mutation | rs778277949 | c.938N>T | p.Thr313Met | p.T313M | P0CK96 | protein_coding | deleterious(0.02) | probably_damaging(0.995) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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