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Gene: SEP15 |
Gene summary for SEP15 |
Gene summary. |
Gene information | Species | Human | Gene symbol | SEP15 | Gene ID | 9403 |
Gene name | selenoprotein F | |
Gene Alias | SEP15 | |
Cytomap | 1p22.3 | |
Gene Type | protein-coding | GO ID | GO:0006457 | UniProtAcc | O60613 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9403 | SEP15 | EEC-subject4 | Human | Endometrium | EEC | 1.29e-58 | -6.99e-01 | -0.2571 |
9403 | SEP15 | EEC-subject5 | Human | Endometrium | EEC | 4.08e-58 | -6.99e-01 | -0.249 |
9403 | SEP15 | GSM5276934 | Human | Endometrium | EEC | 1.19e-55 | -6.99e-01 | -0.0913 |
9403 | SEP15 | GSM5276935 | Human | Endometrium | EEC | 1.28e-57 | -6.99e-01 | -0.123 |
9403 | SEP15 | GSM5276937 | Human | Endometrium | EEC | 3.21e-47 | -6.99e-01 | -0.0897 |
9403 | SEP15 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 1.57e-41 | -6.99e-01 | -0.1869 |
9403 | SEP15 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 2.48e-37 | -6.99e-01 | -0.1875 |
9403 | SEP15 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 7.14e-43 | -6.99e-01 | -0.1883 |
9403 | SEP15 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 1.25e-56 | -6.99e-01 | -0.1934 |
9403 | SEP15 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 3.98e-60 | -6.99e-01 | -0.1917 |
9403 | SEP15 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 2.52e-54 | -6.99e-01 | -0.1916 |
9403 | SEP15 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 1.29e-58 | -6.99e-01 | -0.1269 |
9403 | SEP15 | LZE4T | Human | Esophagus | ESCC | 1.99e-05 | -5.42e-01 | 0.0811 |
9403 | SEP15 | LZE8T | Human | Esophagus | ESCC | 9.69e-05 | -5.42e-01 | 0.067 |
9403 | SEP15 | LZE20T | Human | Esophagus | ESCC | 7.42e-05 | -5.42e-01 | 0.0662 |
9403 | SEP15 | LZE24T | Human | Esophagus | ESCC | 2.03e-08 | -5.42e-01 | 0.0596 |
9403 | SEP15 | LZE6T | Human | Esophagus | ESCC | 1.34e-02 | -5.42e-01 | 0.0845 |
9403 | SEP15 | P1T-E | Human | Esophagus | ESCC | 4.76e-05 | 9.21e-01 | 0.0875 |
9403 | SEP15 | P2T-E | Human | Esophagus | ESCC | 2.74e-46 | 1.09e+00 | 0.1177 |
9403 | SEP15 | P4T-E | Human | Esophagus | ESCC | 6.34e-42 | 1.20e+00 | 0.1323 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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