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Gene: SDC2 |
Gene summary for SDC2 |
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Gene information | Species | Human | Gene symbol | SDC2 | Gene ID | 6383 |
Gene name | syndecan 2 | |
Gene Alias | CD362 | |
Cytomap | 8q22.1 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | A0A024R9D1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6383 | SDC2 | HCC1 | Human | Liver | HCC | 3.77e-33 | 5.54e+00 | 0.5336 |
6383 | SDC2 | HCC2 | Human | Liver | HCC | 2.74e-29 | 5.08e+00 | 0.5341 |
6383 | SDC2 | HCC5 | Human | Liver | HCC | 3.82e-04 | 1.35e+00 | 0.4932 |
6383 | SDC2 | Pt13.a | Human | Liver | HCC | 9.35e-13 | 6.00e-01 | 0.021 |
6383 | SDC2 | Pt13.b | Human | Liver | HCC | 3.38e-47 | 7.19e-01 | 0.0251 |
6383 | SDC2 | Pt14.a | Human | Liver | HCC | 3.43e-05 | 4.96e-01 | 0.0169 |
6383 | SDC2 | Pt14.b | Human | Liver | HCC | 2.47e-17 | 7.65e-01 | 0.018 |
6383 | SDC2 | Pt14.d | Human | Liver | HCC | 4.74e-02 | 3.34e-01 | 0.0143 |
6383 | SDC2 | S014 | Human | Liver | HCC | 1.44e-56 | 3.19e+00 | 0.2254 |
6383 | SDC2 | S015 | Human | Liver | HCC | 8.04e-52 | 3.80e+00 | 0.2375 |
6383 | SDC2 | S016 | Human | Liver | HCC | 5.16e-65 | 3.17e+00 | 0.2243 |
6383 | SDC2 | S028 | Human | Liver | HCC | 2.20e-11 | 8.97e-01 | 0.2503 |
6383 | SDC2 | S029 | Human | Liver | HCC | 1.95e-12 | 1.01e+00 | 0.2581 |
6383 | SDC2 | C43 | Human | Oral cavity | OSCC | 1.83e-03 | -1.44e-03 | 0.1704 |
6383 | SDC2 | C08 | Human | Oral cavity | OSCC | 5.15e-33 | 1.37e+00 | 0.1919 |
6383 | SDC2 | C09 | Human | Oral cavity | OSCC | 1.43e-05 | 4.51e-01 | 0.1431 |
6383 | SDC2 | NEOLP-1 | Human | Oral cavity | NEOLP | 2.74e-09 | 4.97e-01 | -0.0194 |
6383 | SDC2 | NEOLP-2 | Human | Oral cavity | NEOLP | 2.57e-07 | 3.44e-01 | -0.0196 |
6383 | SDC2 | NEOLP-3 | Human | Oral cavity | NEOLP | 2.32e-03 | 1.86e-01 | -0.0191 |
6383 | SDC2 | P1_S1_AK | Human | Skin | AK | 1.38e-06 | -4.18e-01 | -0.3399 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00109758 | Endometrium | AEH | regulation of neuron projection development | 75/2100 | 445/18723 | 2.01e-04 | 2.54e-03 | 75 |
GO:00163588 | Endometrium | AEH | dendrite development | 46/2100 | 243/18723 | 2.56e-04 | 3.03e-03 | 46 |
GO:001097513 | Endometrium | EEC | regulation of neuron projection development | 79/2168 | 445/18723 | 6.80e-05 | 1.01e-03 | 79 |
GO:001635813 | Endometrium | EEC | dendrite development | 44/2168 | 243/18723 | 1.72e-03 | 1.34e-02 | 44 |
GO:001097516 | Esophagus | ESCC | regulation of neuron projection development | 240/8552 | 445/18723 | 2.48e-04 | 1.53e-03 | 240 |
GO:001635816 | Esophagus | ESCC | dendrite development | 130/8552 | 243/18723 | 8.33e-03 | 2.95e-02 | 130 |
GO:00163585 | Liver | NAFLD | dendrite development | 43/1882 | 243/18723 | 1.70e-04 | 3.07e-03 | 43 |
GO:00488133 | Liver | NAFLD | dendrite morphogenesis | 29/1882 | 146/18723 | 2.63e-04 | 4.26e-03 | 29 |
GO:00109755 | Liver | NAFLD | regulation of neuron projection development | 64/1882 | 445/18723 | 2.12e-03 | 2.08e-02 | 64 |
GO:001097511 | Liver | HCC | regulation of neuron projection development | 220/7958 | 445/18723 | 1.68e-03 | 8.78e-03 | 220 |
GO:001635811 | Liver | HCC | dendrite development | 121/7958 | 243/18723 | 1.26e-02 | 4.56e-02 | 121 |
GO:001097510 | Oral cavity | OSCC | regulation of neuron projection development | 210/7305 | 445/18723 | 2.35e-04 | 1.52e-03 | 210 |
GO:001635810 | Oral cavity | OSCC | dendrite development | 113/7305 | 243/18723 | 1.00e-02 | 3.49e-02 | 113 |
GO:001635822 | Oral cavity | NEOLP | dendrite development | 55/2005 | 243/18723 | 5.38e-08 | 2.16e-06 | 55 |
GO:004881313 | Oral cavity | NEOLP | dendrite morphogenesis | 34/2005 | 146/18723 | 9.34e-06 | 1.79e-04 | 34 |
GO:001097521 | Oral cavity | NEOLP | regulation of neuron projection development | 77/2005 | 445/18723 | 1.44e-05 | 2.53e-04 | 77 |
GO:00109759 | Prostate | BPH | regulation of neuron projection development | 118/3107 | 445/18723 | 5.85e-08 | 1.57e-06 | 118 |
GO:00163589 | Prostate | BPH | dendrite development | 71/3107 | 243/18723 | 5.73e-07 | 1.14e-05 | 71 |
GO:00488136 | Prostate | BPH | dendrite morphogenesis | 45/3107 | 146/18723 | 1.46e-05 | 1.88e-04 | 45 |
GO:0048814 | Prostate | BPH | regulation of dendrite morphogenesis | 20/3107 | 67/18723 | 4.93e-03 | 2.33e-02 | 20 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0541824 | Breast | IDC | Fluid shear stress and atherosclerosis | 34/867 | 139/8465 | 9.41e-07 | 1.61e-05 | 1.20e-05 | 34 |
hsa0520523 | Breast | IDC | Proteoglycans in cancer | 42/867 | 205/8465 | 7.69e-06 | 9.99e-05 | 7.48e-05 | 42 |
hsa0541834 | Breast | IDC | Fluid shear stress and atherosclerosis | 34/867 | 139/8465 | 9.41e-07 | 1.61e-05 | 1.20e-05 | 34 |
hsa0520533 | Breast | IDC | Proteoglycans in cancer | 42/867 | 205/8465 | 7.69e-06 | 9.99e-05 | 7.48e-05 | 42 |
hsa0541826 | Endometrium | AEH | Fluid shear stress and atherosclerosis | 43/1197 | 139/8465 | 2.47e-07 | 3.49e-06 | 2.55e-06 | 43 |
hsa0520518 | Endometrium | AEH | Proteoglycans in cancer | 53/1197 | 205/8465 | 5.43e-06 | 6.53e-05 | 4.78e-05 | 53 |
hsa05418112 | Endometrium | AEH | Fluid shear stress and atherosclerosis | 43/1197 | 139/8465 | 2.47e-07 | 3.49e-06 | 2.55e-06 | 43 |
hsa0520519 | Endometrium | AEH | Proteoglycans in cancer | 53/1197 | 205/8465 | 5.43e-06 | 6.53e-05 | 4.78e-05 | 53 |
hsa0541827 | Endometrium | EEC | Fluid shear stress and atherosclerosis | 45/1237 | 139/8465 | 7.76e-08 | 1.22e-06 | 9.07e-07 | 45 |
hsa0520524 | Endometrium | EEC | Proteoglycans in cancer | 52/1237 | 205/8465 | 3.01e-05 | 3.19e-04 | 2.38e-04 | 52 |
hsa0541836 | Endometrium | EEC | Fluid shear stress and atherosclerosis | 45/1237 | 139/8465 | 7.76e-08 | 1.22e-06 | 9.07e-07 | 45 |
hsa0520534 | Endometrium | EEC | Proteoglycans in cancer | 52/1237 | 205/8465 | 3.01e-05 | 3.19e-04 | 2.38e-04 | 52 |
hsa05418211 | Esophagus | ESCC | Fluid shear stress and atherosclerosis | 109/4205 | 139/8465 | 2.00e-12 | 3.72e-11 | 1.90e-11 | 109 |
hsa0520529 | Esophagus | ESCC | Proteoglycans in cancer | 138/4205 | 205/8465 | 1.79e-07 | 1.40e-06 | 7.15e-07 | 138 |
hsa05418310 | Esophagus | ESCC | Fluid shear stress and atherosclerosis | 109/4205 | 139/8465 | 2.00e-12 | 3.72e-11 | 1.90e-11 | 109 |
hsa0520537 | Esophagus | ESCC | Proteoglycans in cancer | 138/4205 | 205/8465 | 1.79e-07 | 1.40e-06 | 7.15e-07 | 138 |
hsa0541814 | Liver | NAFLD | Fluid shear stress and atherosclerosis | 30/1043 | 139/8465 | 1.37e-03 | 1.71e-02 | 1.38e-02 | 30 |
hsa0541815 | Liver | NAFLD | Fluid shear stress and atherosclerosis | 30/1043 | 139/8465 | 1.37e-03 | 1.71e-02 | 1.38e-02 | 30 |
hsa0541822 | Liver | Cirrhotic | Fluid shear stress and atherosclerosis | 62/2530 | 139/8465 | 1.53e-04 | 1.06e-03 | 6.54e-04 | 62 |
hsa0520510 | Liver | Cirrhotic | Proteoglycans in cancer | 85/2530 | 205/8465 | 2.37e-04 | 1.58e-03 | 9.75e-04 | 85 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
ANGPTL4 | SDC2 | ANGPTL4_SDC2 | ANGPTL | Breast | ADJ |
MDK | SDC2 | MDK_SDC2 | MK | Breast | ADJ |
MDK | SDC2 | MDK_SDC2 | MK | Breast | DCIS |
PTN | SDC2 | PTN_SDC2 | PTN | Breast | DCIS |
ANGPTL4 | SDC2 | ANGPTL4_SDC2 | ANGPTL | Breast | DCIS |
MDK | SDC2 | MDK_SDC2 | MK | Breast | Healthy |
ANGPTL4 | SDC2 | ANGPTL4_SDC2 | ANGPTL | Breast | Healthy |
PTN | SDC2 | PTN_SDC2 | PTN | Breast | Healthy |
MDK | SDC2 | MDK_SDC2 | MK | Breast | IDC |
ANGPTL4 | SDC2 | ANGPTL4_SDC2 | ANGPTL | Breast | IDC |
ANGPTL4 | SDC2 | ANGPTL4_SDC2 | ANGPTL | Breast | Precancer |
MDK | SDC2 | MDK_SDC2 | MK | Breast | Precancer |
MDK | SDC2 | MDK_SDC2 | MK | Cervix | ADJ |
PTN | SDC2 | PTN_SDC2 | PTN | Cervix | ADJ |
MDK | SDC2 | MDK_SDC2 | MK | Cervix | CC |
PTN | SDC2 | PTN_SDC2 | PTN | Cervix | CC |
ANGPTL4 | SDC2 | ANGPTL4_SDC2 | ANGPTL | Cervix | CC |
MDK | SDC2 | MDK_SDC2 | MK | Cervix | Healthy |
MDK | SDC2 | MDK_SDC2 | MK | Cervix | Precancer |
PTN | SDC2 | PTN_SDC2 | PTN | Cervix | Precancer |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SDC2 | SNV | Missense_Mutation | rs200028820 | c.373N>A | p.Glu125Lys | p.E125K | P34741 | protein_coding | tolerated(0.83) | benign(0.207) | TCGA-D8-A1XZ-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen+anastrozolum | SD |
SDC2 | SNV | Missense_Mutation | c.144C>A | p.Asp48Glu | p.D48E | P34741 | protein_coding | tolerated(0.07) | probably_damaging(0.999) | TCGA-E9-A1R7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | fareston | SD | |
SDC2 | insertion | Frame_Shift_Ins | novel | c.583_584insATTTCATATT | p.Pro195HisfsTer6 | p.P195Hfs*6 | P34741 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SDC2 | SNV | Missense_Mutation | rs200028820 | c.373N>A | p.Glu125Lys | p.E125K | P34741 | protein_coding | tolerated(0.83) | benign(0.207) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SDC2 | SNV | Missense_Mutation | c.593A>G | p.Glu198Gly | p.E198G | P34741 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AZ-5403-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
SDC2 | SNV | Missense_Mutation | novel | c.26N>G | p.Thr9Ser | p.T9S | P34741 | protein_coding | tolerated(0.32) | benign(0.001) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
SDC2 | SNV | Missense_Mutation | rs774751152 | c.509N>A | p.Arg170His | p.R170H | P34741 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SDC2 | SNV | Missense_Mutation | c.479N>A | p.Ala160Glu | p.A160E | P34741 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AF-2690-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
SDC2 | SNV | Missense_Mutation | novel | c.472N>A | p.Leu158Ile | p.L158I | P34741 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SDC2 | SNV | Missense_Mutation | rs774751152 | c.509N>A | p.Arg170His | p.R170H | P34741 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EI-6514-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Chemotherapy | 5-fu | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6383 | SDC2 | CELL SURFACE, DRUGGABLE GENOME | HEPARAN SULFATE | 8642635 |
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