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Gene: SDAD1 |
Gene summary for SDAD1 |
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Gene information | Species | Human | Gene symbol | SDAD1 | Gene ID | 55153 |
Gene name | SDA1 domain containing 1 | |
Gene Alias | SDAD1 | |
Cytomap | 4q21.1 | |
Gene Type | protein-coding | GO ID | GO:0000054 | UniProtAcc | B4DT66 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55153 | SDAD1 | P130T-E | Human | Esophagus | ESCC | 8.43e-43 | 9.46e-01 | 0.1676 |
55153 | SDAD1 | HCC1_Meng | Human | Liver | HCC | 1.76e-69 | 1.32e-01 | 0.0246 |
55153 | SDAD1 | HCC2_Meng | Human | Liver | HCC | 2.80e-13 | 4.68e-02 | 0.0107 |
55153 | SDAD1 | HCC2 | Human | Liver | HCC | 9.31e-24 | 4.97e+00 | 0.5341 |
55153 | SDAD1 | Pt13.b | Human | Liver | HCC | 2.90e-04 | 1.11e-01 | 0.0251 |
55153 | SDAD1 | Pt14.a | Human | Liver | HCC | 1.66e-02 | 2.82e-01 | 0.0169 |
55153 | SDAD1 | S014 | Human | Liver | HCC | 9.19e-10 | 5.76e-01 | 0.2254 |
55153 | SDAD1 | S015 | Human | Liver | HCC | 6.08e-16 | 8.84e-01 | 0.2375 |
55153 | SDAD1 | S016 | Human | Liver | HCC | 3.30e-12 | 5.47e-01 | 0.2243 |
55153 | SDAD1 | S027 | Human | Liver | HCC | 1.03e-05 | 7.81e-01 | 0.2446 |
55153 | SDAD1 | S028 | Human | Liver | HCC | 5.33e-26 | 1.26e+00 | 0.2503 |
55153 | SDAD1 | S029 | Human | Liver | HCC | 7.13e-22 | 1.32e+00 | 0.2581 |
55153 | SDAD1 | C04 | Human | Oral cavity | OSCC | 2.12e-02 | 5.43e-01 | 0.2633 |
55153 | SDAD1 | C21 | Human | Oral cavity | OSCC | 1.50e-27 | 1.14e+00 | 0.2678 |
55153 | SDAD1 | C30 | Human | Oral cavity | OSCC | 8.40e-18 | 1.07e+00 | 0.3055 |
55153 | SDAD1 | C43 | Human | Oral cavity | OSCC | 1.45e-19 | 5.66e-01 | 0.1704 |
55153 | SDAD1 | C46 | Human | Oral cavity | OSCC | 4.54e-04 | 2.78e-01 | 0.1673 |
55153 | SDAD1 | C51 | Human | Oral cavity | OSCC | 3.14e-02 | 4.34e-01 | 0.2674 |
55153 | SDAD1 | C57 | Human | Oral cavity | OSCC | 2.05e-03 | 3.75e-01 | 0.1679 |
55153 | SDAD1 | C08 | Human | Oral cavity | OSCC | 4.66e-12 | 4.33e-01 | 0.1919 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:0006913110 | Esophagus | ESCC | nucleocytoplasmic transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:0051169110 | Esophagus | ESCC | nuclear transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:005165617 | Esophagus | ESCC | establishment of organelle localization | 273/8552 | 390/18723 | 9.13e-23 | 1.81e-20 | 273 |
GO:0051168110 | Esophagus | ESCC | nuclear export | 126/8552 | 154/18723 | 1.88e-20 | 2.65e-18 | 126 |
GO:0042273111 | Esophagus | ESCC | ribosomal large subunit biogenesis | 65/8552 | 72/18723 | 1.53e-15 | 9.82e-14 | 65 |
GO:007116612 | Esophagus | ESCC | ribonucleoprotein complex localization | 66/8552 | 77/18723 | 2.94e-13 | 1.38e-11 | 66 |
GO:007142612 | Esophagus | ESCC | ribonucleoprotein complex export from nucleus | 65/8552 | 76/18723 | 5.56e-13 | 2.50e-11 | 65 |
GO:003150314 | Esophagus | ESCC | protein-containing complex localization | 139/8552 | 220/18723 | 1.14e-07 | 1.85e-06 | 139 |
GO:000005411 | Esophagus | ESCC | ribosomal subunit export from nucleus | 13/8552 | 14/18723 | 3.02e-04 | 1.81e-03 | 13 |
GO:003375011 | Esophagus | ESCC | ribosome localization | 13/8552 | 14/18723 | 3.02e-04 | 1.81e-03 | 13 |
GO:007142811 | Esophagus | ESCC | rRNA-containing ribonucleoprotein complex export from nucleus | 13/8552 | 15/18723 | 1.31e-03 | 6.26e-03 | 13 |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
GO:004225422 | Liver | HCC | ribosome biogenesis | 246/7958 | 299/18723 | 4.99e-46 | 1.58e-42 | 246 |
GO:000691322 | Liver | HCC | nucleocytoplasmic transport | 208/7958 | 301/18723 | 5.51e-21 | 8.12e-19 | 208 |
GO:005116922 | Liver | HCC | nuclear transport | 208/7958 | 301/18723 | 5.51e-21 | 8.12e-19 | 208 |
GO:004227322 | Liver | HCC | ribosomal large subunit biogenesis | 64/7958 | 72/18723 | 2.31e-16 | 2.03e-14 | 64 |
GO:005116822 | Liver | HCC | nuclear export | 113/7958 | 154/18723 | 6.30e-15 | 4.39e-13 | 113 |
GO:005165621 | Liver | HCC | establishment of organelle localization | 226/7958 | 390/18723 | 4.15e-10 | 1.34e-08 | 226 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SDAD1 | SNV | Missense_Mutation | c.1005N>G | p.Phe335Leu | p.F335L | Q9NVU7 | protein_coding | tolerated(0.05) | benign(0.242) | TCGA-BH-A18P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
SDAD1 | insertion | Frame_Shift_Ins | novel | c.1397_1398insGGGCTTCC | p.Tyr467GlyfsTer7 | p.Y467Gfs*7 | Q9NVU7 | protein_coding | TCGA-B6-A0IN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
SDAD1 | deletion | Frame_Shift_Del | c.1716delN | p.Lys574AsnfsTer10 | p.K574Nfs*10 | Q9NVU7 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |||
SDAD1 | SNV | Missense_Mutation | rs773176883 | c.526G>A | p.Ala176Thr | p.A176T | Q9NVU7 | protein_coding | tolerated(0.08) | benign(0.207) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SDAD1 | SNV | Missense_Mutation | c.55N>G | p.Leu19Val | p.L19V | Q9NVU7 | protein_coding | deleterious(0.02) | benign(0.266) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
SDAD1 | SNV | Missense_Mutation | c.388G>A | p.Asp130Asn | p.D130N | Q9NVU7 | protein_coding | deleterious(0.03) | probably_damaging(0.973) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
SDAD1 | SNV | Missense_Mutation | rs557777418 | c.1871G>A | p.Arg624Gln | p.R624Q | Q9NVU7 | protein_coding | deleterious(0) | benign(0.385) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD |
SDAD1 | SNV | Missense_Mutation | c.438G>T | p.Lys146Asn | p.K146N | Q9NVU7 | protein_coding | deleterious(0) | probably_damaging(0.959) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SDAD1 | SNV | Missense_Mutation | c.1935N>T | p.Lys645Asn | p.K645N | Q9NVU7 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SDAD1 | SNV | Missense_Mutation | c.1336N>G | p.Met446Val | p.M446V | Q9NVU7 | protein_coding | deleterious(0.01) | benign(0.338) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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