Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: SDAD1

Gene summary for SDAD1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

SDAD1

Gene ID

55153

Gene nameSDA1 domain containing 1
Gene AliasSDAD1
Cytomap4q21.1
Gene Typeprotein-coding
GO ID

GO:0000054

UniProtAcc

B4DT66


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
55153SDAD1P130T-EHumanEsophagusESCC8.43e-439.46e-010.1676
55153SDAD1HCC1_MengHumanLiverHCC1.76e-691.32e-010.0246
55153SDAD1HCC2_MengHumanLiverHCC2.80e-134.68e-020.0107
55153SDAD1HCC2HumanLiverHCC9.31e-244.97e+000.5341
55153SDAD1Pt13.bHumanLiverHCC2.90e-041.11e-010.0251
55153SDAD1Pt14.aHumanLiverHCC1.66e-022.82e-010.0169
55153SDAD1S014HumanLiverHCC9.19e-105.76e-010.2254
55153SDAD1S015HumanLiverHCC6.08e-168.84e-010.2375
55153SDAD1S016HumanLiverHCC3.30e-125.47e-010.2243
55153SDAD1S027HumanLiverHCC1.03e-057.81e-010.2446
55153SDAD1S028HumanLiverHCC5.33e-261.26e+000.2503
55153SDAD1S029HumanLiverHCC7.13e-221.32e+000.2581
55153SDAD1C04HumanOral cavityOSCC2.12e-025.43e-010.2633
55153SDAD1C21HumanOral cavityOSCC1.50e-271.14e+000.2678
55153SDAD1C30HumanOral cavityOSCC8.40e-181.07e+000.3055
55153SDAD1C43HumanOral cavityOSCC1.45e-195.66e-010.1704
55153SDAD1C46HumanOral cavityOSCC4.54e-042.78e-010.1673
55153SDAD1C51HumanOral cavityOSCC3.14e-024.34e-010.2674
55153SDAD1C57HumanOral cavityOSCC2.05e-033.75e-010.1679
55153SDAD1C08HumanOral cavityOSCC4.66e-124.33e-010.1919
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0022613111EsophagusESCCribonucleoprotein complex biogenesis365/8552463/187231.74e-491.11e-45365
GO:0042254111EsophagusESCCribosome biogenesis252/8552299/187233.27e-441.04e-40252
GO:0006913110EsophagusESCCnucleocytoplasmic transport230/8552301/187236.04e-282.02e-25230
GO:0051169110EsophagusESCCnuclear transport230/8552301/187236.04e-282.02e-25230
GO:005165617EsophagusESCCestablishment of organelle localization273/8552390/187239.13e-231.81e-20273
GO:0051168110EsophagusESCCnuclear export126/8552154/187231.88e-202.65e-18126
GO:0042273111EsophagusESCCribosomal large subunit biogenesis65/855272/187231.53e-159.82e-1465
GO:007116612EsophagusESCCribonucleoprotein complex localization66/855277/187232.94e-131.38e-1166
GO:007142612EsophagusESCCribonucleoprotein complex export from nucleus65/855276/187235.56e-132.50e-1165
GO:003150314EsophagusESCCprotein-containing complex localization139/8552220/187231.14e-071.85e-06139
GO:000005411EsophagusESCCribosomal subunit export from nucleus13/855214/187233.02e-041.81e-0313
GO:003375011EsophagusESCCribosome localization13/855214/187233.02e-041.81e-0313
GO:007142811EsophagusESCCrRNA-containing ribonucleoprotein complex export from nucleus13/855215/187231.31e-036.26e-0313
GO:002261322LiverHCCribonucleoprotein complex biogenesis355/7958463/187237.76e-524.92e-48355
GO:004225422LiverHCCribosome biogenesis246/7958299/187234.99e-461.58e-42246
GO:000691322LiverHCCnucleocytoplasmic transport208/7958301/187235.51e-218.12e-19208
GO:005116922LiverHCCnuclear transport208/7958301/187235.51e-218.12e-19208
GO:004227322LiverHCCribosomal large subunit biogenesis64/795872/187232.31e-162.03e-1464
GO:005116822LiverHCCnuclear export113/7958154/187236.30e-154.39e-13113
GO:005165621LiverHCCestablishment of organelle localization226/7958390/187234.15e-101.34e-08226
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
SDAD1SNVMissense_Mutationc.1005N>Gp.Phe335Leup.F335LQ9NVU7protein_codingtolerated(0.05)benign(0.242)TCGA-BH-A18P-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownPD
SDAD1insertionFrame_Shift_Insnovelc.1397_1398insGGGCTTCCp.Tyr467GlyfsTer7p.Y467Gfs*7Q9NVU7protein_codingTCGA-B6-A0IN-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownPD
SDAD1deletionFrame_Shift_Delc.1716delNp.Lys574AsnfsTer10p.K574Nfs*10Q9NVU7protein_codingTCGA-D8-A27V-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
SDAD1SNVMissense_Mutationrs773176883c.526G>Ap.Ala176Thrp.A176TQ9NVU7protein_codingtolerated(0.08)benign(0.207)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
SDAD1SNVMissense_Mutationc.55N>Gp.Leu19Valp.L19VQ9NVU7protein_codingdeleterious(0.02)benign(0.266)TCGA-EK-A3GK-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
SDAD1SNVMissense_Mutationc.388G>Ap.Asp130Asnp.D130NQ9NVU7protein_codingdeleterious(0.03)probably_damaging(0.973)TCGA-VS-A958-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
SDAD1SNVMissense_Mutationrs557777418c.1871G>Ap.Arg624Glnp.R624QQ9NVU7protein_codingdeleterious(0)benign(0.385)TCGA-A6-6141-01Colorectumcolon adenocarcinomaMale<65I/IIChemotherapy5-fuSD
SDAD1SNVMissense_Mutationc.438G>Tp.Lys146Asnp.K146NQ9NVU7protein_codingdeleterious(0)probably_damaging(0.959)TCGA-AA-3510-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
SDAD1SNVMissense_Mutationc.1935N>Tp.Lys645Asnp.K645NQ9NVU7protein_codingdeleterious(0.01)probably_damaging(1)TCGA-AA-3984-01Colorectumcolon adenocarcinomaFemale<65I/IIUnknownUnknownSD
SDAD1SNVMissense_Mutationc.1336N>Gp.Met446Valp.M446VQ9NVU7protein_codingdeleterious(0.01)benign(0.338)TCGA-CA-6717-01Colorectumcolon adenocarcinomaMale<65I/IIChemotherapyoxaliplatinCR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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