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Gene: S100A8 |
Gene summary for S100A8 |
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Gene information | Species | Human | Gene symbol | S100A8 | Gene ID | 6279 |
Gene name | S100 calcium binding protein A8 | |
Gene Alias | 60B8AG | |
Cytomap | 1q21.3 | |
Gene Type | protein-coding | GO ID | GO:0001558 | UniProtAcc | P05109 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6279 | S100A8 | LZE21T | Human | Esophagus | ESCC | 7.32e-03 | 1.19e+00 | 0.0655 |
6279 | S100A8 | LZE6T | Human | Esophagus | ESCC | 2.01e-14 | 2.06e+00 | 0.0845 |
6279 | S100A8 | P1T-E | Human | Esophagus | ESCC | 4.84e-39 | 6.77e+00 | 0.0875 |
6279 | S100A8 | P4T-E | Human | Esophagus | ESCC | 2.23e-31 | 3.18e+00 | 0.1323 |
6279 | S100A8 | P5T-E | Human | Esophagus | ESCC | 4.58e-07 | 1.25e+00 | 0.1327 |
6279 | S100A8 | P11T-E | Human | Esophagus | ESCC | 4.63e-16 | 3.50e+00 | 0.1426 |
6279 | S100A8 | P15T-E | Human | Esophagus | ESCC | 1.85e-03 | 1.97e+00 | 0.1149 |
6279 | S100A8 | P17T-E | Human | Esophagus | ESCC | 9.33e-33 | 3.44e+00 | 0.1278 |
6279 | S100A8 | P19T-E | Human | Esophagus | ESCC | 1.42e-08 | 3.80e+00 | 0.1662 |
6279 | S100A8 | P20T-E | Human | Esophagus | ESCC | 2.40e-69 | 5.25e+00 | 0.1124 |
6279 | S100A8 | P21T-E | Human | Esophagus | ESCC | 7.06e-49 | 4.06e+00 | 0.1617 |
6279 | S100A8 | P22T-E | Human | Esophagus | ESCC | 5.36e-08 | 6.74e-01 | 0.1236 |
6279 | S100A8 | P23T-E | Human | Esophagus | ESCC | 1.61e-65 | 5.30e+00 | 0.108 |
6279 | S100A8 | P24T-E | Human | Esophagus | ESCC | 8.62e-48 | 3.44e+00 | 0.1287 |
6279 | S100A8 | P27T-E | Human | Esophagus | ESCC | 5.71e-13 | 1.87e+00 | 0.1055 |
6279 | S100A8 | P30T-E | Human | Esophagus | ESCC | 9.53e-06 | 1.86e+00 | 0.137 |
6279 | S100A8 | P31T-E | Human | Esophagus | ESCC | 5.89e-05 | 2.54e+00 | 0.1251 |
6279 | S100A8 | P32T-E | Human | Esophagus | ESCC | 3.46e-21 | 1.67e+00 | 0.1666 |
6279 | S100A8 | P36T-E | Human | Esophagus | ESCC | 6.34e-22 | 4.21e+00 | 0.1187 |
6279 | S100A8 | P37T-E | Human | Esophagus | ESCC | 1.46e-33 | 2.64e+00 | 0.1371 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00971939 | Breast | Precancer | intrinsic apoptotic signaling pathway | 59/1080 | 288/18723 | 8.07e-18 | 3.60e-15 | 59 |
GO:20012339 | Breast | Precancer | regulation of apoptotic signaling pathway | 65/1080 | 356/18723 | 7.70e-17 | 3.17e-14 | 65 |
GO:20012429 | Breast | Precancer | regulation of intrinsic apoptotic signaling pathway | 41/1080 | 164/18723 | 6.48e-16 | 2.31e-13 | 41 |
GO:00525479 | Breast | Precancer | regulation of peptidase activity | 71/1080 | 461/18723 | 2.72e-14 | 6.94e-12 | 71 |
GO:00525489 | Breast | Precancer | regulation of endopeptidase activity | 67/1080 | 432/18723 | 1.06e-13 | 2.36e-11 | 67 |
GO:20001169 | Breast | Precancer | regulation of cysteine-type endopeptidase activity | 43/1080 | 235/18723 | 1.30e-11 | 1.83e-09 | 43 |
GO:00432819 | Breast | Precancer | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 40/1080 | 209/18723 | 1.59e-11 | 2.07e-09 | 40 |
GO:00458629 | Breast | Precancer | positive regulation of proteolysis | 51/1080 | 372/18723 | 7.77e-09 | 5.70e-07 | 51 |
GO:20012445 | Breast | Precancer | positive regulation of intrinsic apoptotic signaling pathway | 17/1080 | 58/18723 | 1.59e-08 | 1.12e-06 | 17 |
GO:00109529 | Breast | Precancer | positive regulation of peptidase activity | 33/1080 | 197/18723 | 3.01e-08 | 1.89e-06 | 33 |
GO:00975297 | Breast | Precancer | myeloid leukocyte migration | 34/1080 | 220/18723 | 1.42e-07 | 7.82e-06 | 34 |
GO:20012356 | Breast | Precancer | positive regulation of apoptotic signaling pathway | 24/1080 | 126/18723 | 1.98e-07 | 1.01e-05 | 24 |
GO:00509006 | Breast | Precancer | leukocyte migration | 47/1080 | 369/18723 | 2.82e-07 | 1.39e-05 | 47 |
GO:00432808 | Breast | Precancer | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 24/1080 | 129/18723 | 3.13e-07 | 1.50e-05 | 24 |
GO:00100389 | Breast | Precancer | response to metal ion | 47/1080 | 373/18723 | 3.88e-07 | 1.79e-05 | 47 |
GO:00305956 | Breast | Precancer | leukocyte chemotaxis | 34/1080 | 230/18723 | 4.16e-07 | 1.89e-05 | 34 |
GO:00109509 | Breast | Precancer | positive regulation of endopeptidase activity | 29/1080 | 179/18723 | 4.23e-07 | 1.90e-05 | 29 |
GO:00603266 | Breast | Precancer | cell chemotaxis | 41/1080 | 310/18723 | 5.99e-07 | 2.55e-05 | 41 |
GO:00716217 | Breast | Precancer | granulocyte chemotaxis | 23/1080 | 125/18723 | 6.73e-07 | 2.77e-05 | 23 |
GO:20010568 | Breast | Precancer | positive regulation of cysteine-type endopeptidase activity | 25/1080 | 148/18723 | 1.19e-06 | 4.60e-05 | 25 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0465721 | Breast | IDC | IL-17 signaling pathway | 18/867 | 94/8465 | 6.39e-03 | 3.30e-02 | 2.47e-02 | 18 |
hsa0465731 | Breast | IDC | IL-17 signaling pathway | 18/867 | 94/8465 | 6.39e-03 | 3.30e-02 | 2.47e-02 | 18 |
hsa0465741 | Breast | DCIS | IL-17 signaling pathway | 18/846 | 94/8465 | 4.95e-03 | 2.67e-02 | 1.96e-02 | 18 |
hsa0465751 | Breast | DCIS | IL-17 signaling pathway | 18/846 | 94/8465 | 4.95e-03 | 2.67e-02 | 1.96e-02 | 18 |
hsa0465718 | Cervix | CC | IL-17 signaling pathway | 31/1267 | 94/8465 | 8.71e-06 | 7.43e-05 | 4.39e-05 | 31 |
hsa0465719 | Cervix | CC | IL-17 signaling pathway | 31/1267 | 94/8465 | 8.71e-06 | 7.43e-05 | 4.39e-05 | 31 |
hsa0465722 | Cervix | HSIL_HPV | IL-17 signaling pathway | 15/459 | 94/8465 | 1.45e-04 | 1.74e-03 | 1.40e-03 | 15 |
hsa0465732 | Cervix | HSIL_HPV | IL-17 signaling pathway | 15/459 | 94/8465 | 1.45e-04 | 1.74e-03 | 1.40e-03 | 15 |
hsa0465742 | Cervix | N_HPV | IL-17 signaling pathway | 16/349 | 94/8465 | 1.20e-06 | 1.64e-05 | 1.28e-05 | 16 |
hsa0465752 | Cervix | N_HPV | IL-17 signaling pathway | 16/349 | 94/8465 | 1.20e-06 | 1.64e-05 | 1.28e-05 | 16 |
hsa0465726 | Esophagus | HGIN | IL-17 signaling pathway | 25/1383 | 94/8465 | 7.52e-03 | 4.63e-02 | 3.68e-02 | 25 |
hsa04657113 | Esophagus | HGIN | IL-17 signaling pathway | 25/1383 | 94/8465 | 7.52e-03 | 4.63e-02 | 3.68e-02 | 25 |
hsa0465727 | Esophagus | ESCC | IL-17 signaling pathway | 66/4205 | 94/8465 | 3.93e-05 | 1.75e-04 | 8.99e-05 | 66 |
hsa0465734 | Esophagus | ESCC | IL-17 signaling pathway | 66/4205 | 94/8465 | 3.93e-05 | 1.75e-04 | 8.99e-05 | 66 |
hsa0465724 | Oral cavity | OSCC | IL-17 signaling pathway | 64/3704 | 94/8465 | 1.48e-06 | 7.87e-06 | 4.01e-06 | 64 |
hsa04657112 | Oral cavity | OSCC | IL-17 signaling pathway | 64/3704 | 94/8465 | 1.48e-06 | 7.87e-06 | 4.01e-06 | 64 |
hsa0465725 | Oral cavity | LP | IL-17 signaling pathway | 47/2418 | 94/8465 | 8.45e-06 | 6.25e-05 | 4.03e-05 | 47 |
hsa0465733 | Oral cavity | LP | IL-17 signaling pathway | 47/2418 | 94/8465 | 8.45e-06 | 6.25e-05 | 4.03e-05 | 47 |
hsa0465743 | Oral cavity | EOLP | IL-17 signaling pathway | 24/1218 | 94/8465 | 2.98e-03 | 9.61e-03 | 5.67e-03 | 24 |
hsa0465753 | Oral cavity | EOLP | IL-17 signaling pathway | 24/1218 | 94/8465 | 2.98e-03 | 9.61e-03 | 5.67e-03 | 24 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
S100A8 | SNV | Missense_Mutation | c.221N>C | p.Leu74Pro | p.L74P | P05109 | protein_coding | deleterious(0) | possibly_damaging(0.87) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
S100A8 | deletion | Frame_Shift_Del | c.256delA | p.Ser86AlafsTer10 | p.S86Afs*10 | P05109 | protein_coding | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |||
S100A8 | deletion | Frame_Shift_Del | c.256delN | p.Ser86AlafsTer10 | p.S86Afs*10 | P05109 | protein_coding | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
S100A8 | deletion | Frame_Shift_Del | c.256delN | p.Ser86AlafsTer10 | p.S86Afs*10 | P05109 | protein_coding | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
S100A8 | SNV | Missense_Mutation | novel | c.154N>A | p.Asp52Asn | p.D52N | P05109 | protein_coding | tolerated(0.05) | benign(0.003) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
S100A8 | SNV | Missense_Mutation | c.207N>T | p.Gln69His | p.Q69H | P05109 | protein_coding | deleterious(0) | benign(0.258) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
S100A8 | SNV | Missense_Mutation | rs780156471 | c.59C>T | p.Ser20Phe | p.S20F | P05109 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AP-A0LP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Hormone Therapy | megace | SD |
S100A8 | SNV | Missense_Mutation | novel | c.245C>T | p.Ala82Val | p.A82V | P05109 | protein_coding | deleterious(0.03) | possibly_damaging(0.494) | TCGA-DI-A1BY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
S100A8 | SNV | Missense_Mutation | novel | c.263N>C | p.Glu88Ala | p.E88A | P05109 | protein_coding | deleterious(0) | benign(0.011) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
S100A8 | insertion | Frame_Shift_Ins | novel | c.256dupA | p.Ser86LysfsTer3 | p.S86Kfs*3 | P05109 | protein_coding | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6279 | S100A8 | DRUGGABLE GENOME, KINASE, ENZYME | MTX | METHOTREXATE | 14722212 |
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