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Gene: RRP9 |
Gene summary for RRP9 |
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Gene information | Species | Human | Gene symbol | RRP9 | Gene ID | 9136 |
Gene name | ribosomal RNA processing 9, U3 small nucleolar RNA binding protein | |
Gene Alias | RNU3IP2 | |
Cytomap | 3p21.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | O43818 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9136 | RRP9 | Pt13.b | Human | Liver | HCC | 6.27e-03 | 7.61e-02 | 0.0251 |
9136 | RRP9 | S014 | Human | Liver | HCC | 1.03e-19 | 6.96e-01 | 0.2254 |
9136 | RRP9 | S015 | Human | Liver | HCC | 7.72e-25 | 1.03e+00 | 0.2375 |
9136 | RRP9 | S016 | Human | Liver | HCC | 4.84e-19 | 7.08e-01 | 0.2243 |
9136 | RRP9 | S027 | Human | Liver | HCC | 1.28e-10 | 9.14e-01 | 0.2446 |
9136 | RRP9 | S028 | Human | Liver | HCC | 1.74e-24 | 1.28e+00 | 0.2503 |
9136 | RRP9 | S029 | Human | Liver | HCC | 6.09e-30 | 1.16e+00 | 0.2581 |
9136 | RRP9 | C04 | Human | Oral cavity | OSCC | 2.01e-10 | 7.00e-01 | 0.2633 |
9136 | RRP9 | C21 | Human | Oral cavity | OSCC | 5.30e-24 | 8.35e-01 | 0.2678 |
9136 | RRP9 | C30 | Human | Oral cavity | OSCC | 2.08e-38 | 1.42e+00 | 0.3055 |
9136 | RRP9 | C43 | Human | Oral cavity | OSCC | 6.76e-09 | 2.33e-01 | 0.1704 |
9136 | RRP9 | C46 | Human | Oral cavity | OSCC | 1.97e-15 | 3.76e-01 | 0.1673 |
9136 | RRP9 | C51 | Human | Oral cavity | OSCC | 1.12e-03 | 3.97e-01 | 0.2674 |
9136 | RRP9 | C08 | Human | Oral cavity | OSCC | 4.83e-20 | 4.23e-01 | 0.1919 |
9136 | RRP9 | C09 | Human | Oral cavity | OSCC | 7.42e-07 | 2.45e-01 | 0.1431 |
9136 | RRP9 | LN22 | Human | Oral cavity | OSCC | 1.66e-03 | 5.22e-01 | 0.1733 |
9136 | RRP9 | LN46 | Human | Oral cavity | OSCC | 1.09e-12 | 5.18e-01 | 0.1666 |
9136 | RRP9 | LP15 | Human | Oral cavity | LP | 9.46e-05 | 5.45e-01 | 0.2174 |
9136 | RRP9 | SYSMH2 | Human | Oral cavity | OSCC | 7.58e-16 | 4.01e-01 | 0.2326 |
9136 | RRP9 | SYSMH3 | Human | Oral cavity | OSCC | 1.93e-28 | 6.62e-01 | 0.2442 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
GO:004225422 | Liver | HCC | ribosome biogenesis | 246/7958 | 299/18723 | 4.99e-46 | 1.58e-42 | 246 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:001607212 | Liver | HCC | rRNA metabolic process | 193/7958 | 236/18723 | 1.26e-35 | 1.14e-32 | 193 |
GO:000636421 | Liver | HCC | rRNA processing | 185/7958 | 225/18723 | 8.14e-35 | 6.45e-32 | 185 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:002261320 | Oral cavity | OSCC | ribonucleoprotein complex biogenesis | 333/7305 | 463/18723 | 8.28e-48 | 5.24e-44 | 333 |
GO:004225420 | Oral cavity | OSCC | ribosome biogenesis | 230/7305 | 299/18723 | 3.22e-41 | 6.80e-38 | 230 |
GO:000636410 | Oral cavity | OSCC | rRNA processing | 172/7305 | 225/18723 | 1.57e-30 | 1.24e-27 | 172 |
GO:00344709 | Oral cavity | OSCC | ncRNA processing | 263/7305 | 395/18723 | 4.38e-29 | 2.78e-26 | 263 |
GO:001607210 | Oral cavity | OSCC | rRNA metabolic process | 176/7305 | 236/18723 | 6.51e-29 | 3.24e-26 | 176 |
GO:00346605 | Oral cavity | OSCC | ncRNA metabolic process | 296/7305 | 485/18723 | 2.94e-23 | 6.65e-21 | 296 |
GO:0022613110 | Oral cavity | LP | ribonucleoprotein complex biogenesis | 259/4623 | 463/18723 | 7.20e-48 | 2.25e-44 | 259 |
GO:0042254110 | Oral cavity | LP | ribosome biogenesis | 173/4623 | 299/18723 | 8.97e-35 | 1.41e-31 | 173 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RRP9 | insertion | Nonsense_Mutation | novel | c.142_143insTCTCATGCGTATGAATCCTTCAACAATAGATTA | p.Glu48delinsValSerCysValTerIleLeuGlnGlnTerIleLys | p.E48delinsVSCV*ILQQ*IK | O43818 | protein_coding | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD | ||
RRP9 | insertion | Frame_Shift_Ins | novel | c.842_843insTGGCCTGCCATGCCAGTGGGGGCTACATGGGCTGGGGGTGGGCTTGGGCC | p.His282GlyfsTer28 | p.H282Gfs*28 | O43818 | protein_coding | TCGA-A8-A06Q-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
RRP9 | SNV | Missense_Mutation | rs147742914 | c.793G>A | p.Val265Met | p.V265M | O43818 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-C5-A1BL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
RRP9 | SNV | Missense_Mutation | novel | c.458N>C | p.Val153Ala | p.V153A | O43818 | protein_coding | tolerated(0.23) | benign(0.336) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
RRP9 | SNV | Missense_Mutation | c.1147N>A | p.Ala383Thr | p.A383T | O43818 | protein_coding | deleterious(0.01) | benign(0.266) | TCGA-AA-3833-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RRP9 | SNV | Missense_Mutation | c.860N>A | p.Ala287Asp | p.A287D | O43818 | protein_coding | deleterious(0) | benign(0.381) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RRP9 | SNV | Missense_Mutation | novel | c.453N>G | p.Cys151Trp | p.C151W | O43818 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3979-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
RRP9 | SNV | Missense_Mutation | novel | c.518G>T | p.Trp173Leu | p.W173L | O43818 | protein_coding | deleterious(0) | benign(0.119) | TCGA-AA-A02E-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
RRP9 | SNV | Missense_Mutation | c.1147G>A | p.Ala383Thr | p.A383T | O43818 | protein_coding | deleterious(0.01) | benign(0.266) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
RRP9 | SNV | Missense_Mutation | c.1051N>T | p.Gly351Cys | p.G351C | O43818 | protein_coding | deleterious(0) | probably_damaging(0.943) | TCGA-DM-A0XF-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | mayo | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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