Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/RHOT1_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/RHOT1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/RHOT1_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/RHOT1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000683913 | Breast | IDC | mitochondrial transport | 51/1434 | 254/18723 | 1.54e-10 | 1.83e-08 | 51 |
GO:000863713 | Breast | IDC | apoptotic mitochondrial changes | 27/1434 | 107/18723 | 2.29e-08 | 1.57e-06 | 27 |
GO:009055913 | Breast | IDC | regulation of membrane permeability | 17/1434 | 78/18723 | 6.88e-05 | 1.40e-03 | 17 |
GO:000700613 | Breast | IDC | mitochondrial membrane organization | 21/1434 | 116/18723 | 1.78e-04 | 3.00e-03 | 21 |
GO:004690213 | Breast | IDC | regulation of mitochondrial membrane permeability | 14/1434 | 63/18723 | 2.37e-04 | 3.75e-03 | 14 |
GO:009734512 | Breast | IDC | mitochondrial outer membrane permeabilization | 9/1434 | 32/18723 | 4.92e-04 | 6.45e-03 | 9 |
GO:001082113 | Breast | IDC | regulation of mitochondrion organization | 23/1434 | 144/18723 | 5.96e-04 | 7.54e-03 | 23 |
GO:190571012 | Breast | IDC | positive regulation of membrane permeability | 11/1434 | 48/18723 | 8.22e-04 | 9.65e-03 | 11 |
GO:003579413 | Breast | IDC | positive regulation of mitochondrial membrane permeability | 10/1434 | 43/18723 | 1.25e-03 | 1.33e-02 | 10 |
GO:190210812 | Breast | IDC | regulation of mitochondrial membrane permeability involved in apoptotic process | 10/1434 | 45/18723 | 1.80e-03 | 1.74e-02 | 10 |
GO:190211012 | Breast | IDC | positive regulation of mitochondrial membrane permeability involved in apoptotic process | 9/1434 | 38/18723 | 1.89e-03 | 1.81e-02 | 9 |
GO:190268612 | Breast | IDC | mitochondrial outer membrane permeabilization involved in programmed cell death | 9/1434 | 40/18723 | 2.76e-03 | 2.42e-02 | 9 |
GO:000683923 | Breast | DCIS | mitochondrial transport | 51/1390 | 254/18723 | 5.04e-11 | 6.79e-09 | 51 |
GO:000863722 | Breast | DCIS | apoptotic mitochondrial changes | 27/1390 | 107/18723 | 1.19e-08 | 8.75e-07 | 27 |
GO:009055922 | Breast | DCIS | regulation of membrane permeability | 17/1390 | 78/18723 | 4.66e-05 | 9.63e-04 | 17 |
GO:000700622 | Breast | DCIS | mitochondrial membrane organization | 21/1390 | 116/18723 | 1.16e-04 | 2.03e-03 | 21 |
GO:004690222 | Breast | DCIS | regulation of mitochondrial membrane permeability | 14/1390 | 63/18723 | 1.71e-04 | 2.84e-03 | 14 |
GO:001082122 | Breast | DCIS | regulation of mitochondrion organization | 23/1390 | 144/18723 | 3.86e-04 | 5.36e-03 | 23 |
GO:009734521 | Breast | DCIS | mitochondrial outer membrane permeabilization | 9/1390 | 32/18723 | 3.91e-04 | 5.40e-03 | 9 |
GO:190571021 | Breast | DCIS | positive regulation of membrane permeability | 11/1390 | 48/18723 | 6.34e-04 | 7.92e-03 | 11 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RHOT1 | SNV | Missense_Mutation | | c.271G>A | p.Asp91Asn | p.D91N | Q8IXI2 | protein_coding | tolerated(0.07) | benign(0.031) | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
RHOT1 | SNV | Missense_Mutation | | c.690N>T | p.Lys230Asn | p.K230N | Q8IXI2 | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RHOT1 | SNV | Missense_Mutation | | c.854N>G | p.Glu285Gly | p.E285G | Q8IXI2 | protein_coding | deleterious(0) | possibly_damaging(0.562) | TCGA-BH-A0HA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RHOT1 | SNV | Missense_Mutation | | c.115N>C | p.Glu39Gln | p.E39Q | Q8IXI2 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-BH-A18P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
RHOT1 | SNV | Missense_Mutation | | c.1795N>C | p.Glu599Gln | p.E599Q | Q8IXI2 | protein_coding | tolerated_low_confidence(0.55) | benign(0.023) | TCGA-D8-A1Y0-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cyclophosphamide+methotrexatum+fluorouracillum | SD |
RHOT1 | SNV | Missense_Mutation | novel | c.41N>T | p.Arg14Ile | p.R14I | Q8IXI2 | protein_coding | deleterious(0.03) | benign(0.037) | TCGA-LL-A73Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD |
RHOT1 | SNV | Missense_Mutation | novel | c.82N>C | p.Glu28Gln | p.E28Q | Q8IXI2 | protein_coding | deleterious(0.03) | probably_damaging(0.967) | TCGA-C5-A8XJ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | SD |
RHOT1 | SNV | Missense_Mutation | novel | c.664N>A | p.Ala222Thr | p.A222T | Q8IXI2 | protein_coding | tolerated(0.18) | benign(0.053) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
RHOT1 | SNV | Missense_Mutation | | c.727N>A | p.Asp243Asn | p.D243N | Q8IXI2 | protein_coding | tolerated(0.2) | benign(0.017) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RHOT1 | SNV | Missense_Mutation | | c.979N>T | p.Asp327Tyr | p.D327Y | Q8IXI2 | protein_coding | deleterious(0.03) | benign(0.213) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |