![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: RARRES3 |
Gene summary for RARRES3 |
![]() |
Gene information | Species | Human | Gene symbol | RARRES3 | Gene ID | 5920 |
Gene name | phospholipase A and acyltransferase 4 | |
Gene Alias | HRASLS4 | |
Cytomap | 11q12.3 | |
Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | Q9UL19 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5920 | RARRES3 | P52T-E | Human | Esophagus | ESCC | 2.88e-36 | 1.86e+00 | 0.1555 |
5920 | RARRES3 | P56T-E | Human | Esophagus | ESCC | 1.84e-02 | 9.51e-01 | 0.1613 |
5920 | RARRES3 | P57T-E | Human | Esophagus | ESCC | 7.39e-33 | 1.27e+00 | 0.0926 |
5920 | RARRES3 | P62T-E | Human | Esophagus | ESCC | 5.73e-78 | 2.05e+00 | 0.1302 |
5920 | RARRES3 | P65T-E | Human | Esophagus | ESCC | 5.67e-25 | 1.19e+00 | 0.0978 |
5920 | RARRES3 | P74T-E | Human | Esophagus | ESCC | 3.40e-20 | 1.49e+00 | 0.1479 |
5920 | RARRES3 | P75T-E | Human | Esophagus | ESCC | 1.54e-112 | 4.53e+00 | 0.1125 |
5920 | RARRES3 | P76T-E | Human | Esophagus | ESCC | 1.19e-03 | 5.33e-01 | 0.1207 |
5920 | RARRES3 | P80T-E | Human | Esophagus | ESCC | 3.03e-58 | 2.34e+00 | 0.155 |
5920 | RARRES3 | P82T-E | Human | Esophagus | ESCC | 4.13e-24 | 3.74e+00 | 0.1072 |
5920 | RARRES3 | P91T-E | Human | Esophagus | ESCC | 5.66e-04 | 1.31e+00 | 0.1828 |
5920 | RARRES3 | P94T-E | Human | Esophagus | ESCC | 1.58e-07 | 2.49e+00 | 0.0879 |
5920 | RARRES3 | P107T-E | Human | Esophagus | ESCC | 1.37e-09 | 1.00e+00 | 0.171 |
5920 | RARRES3 | P130T-E | Human | Esophagus | ESCC | 2.15e-32 | 1.55e+00 | 0.1676 |
5920 | RARRES3 | S43 | Human | Liver | Cirrhotic | 2.20e-10 | -3.35e-01 | -0.0187 |
5920 | RARRES3 | HCC1_Meng | Human | Liver | HCC | 9.83e-07 | -2.82e-01 | 0.0246 |
5920 | RARRES3 | HCC2_Meng | Human | Liver | HCC | 1.05e-32 | 2.55e-03 | 0.0107 |
5920 | RARRES3 | cirrhotic1 | Human | Liver | Cirrhotic | 8.41e-09 | 1.55e-01 | 0.0202 |
5920 | RARRES3 | cirrhotic2 | Human | Liver | Cirrhotic | 6.63e-18 | 2.50e-01 | 0.0201 |
5920 | RARRES3 | cirrhotic3 | Human | Liver | Cirrhotic | 1.11e-14 | 1.83e-01 | 0.0215 |
Page: 1 2 3 4 5 6 7 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RARRES3 | SNV | Missense_Mutation | rs368947257 | c.191G>A | p.Arg64His | p.R64H | Q9UL19 | protein_coding | tolerated(0.16) | benign(0.006) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RARRES3 | SNV | Missense_Mutation | rs371930466 | c.223C>T | p.Arg75Trp | p.R75W | Q9UL19 | protein_coding | deleterious(0) | benign(0.013) | TCGA-AY-6196-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
RARRES3 | SNV | Missense_Mutation | c.477A>T | p.Gln159His | p.Q159H | Q9UL19 | protein_coding | tolerated(0.1) | benign(0.339) | TCGA-AG-A02G-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folinic | PD | |
RARRES3 | insertion | Frame_Shift_Ins | novel | c.341_342insCT | p.Glu114AspfsTer8 | p.E114Dfs*8 | Q9UL19 | protein_coding | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
RARRES3 | SNV | Missense_Mutation | rs770983321 | c.52N>T | p.Arg18Cys | p.R18C | Q9UL19 | protein_coding | deleterious(0) | probably_damaging(0.949) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
RARRES3 | SNV | Missense_Mutation | rs35845275 | c.485N>T | p.Ala162Val | p.A162V | Q9UL19 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RARRES3 | SNV | Missense_Mutation | c.152N>A | p.Phe51Tyr | p.F51Y | Q9UL19 | protein_coding | deleterious(0) | possibly_damaging(0.69) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RARRES3 | SNV | Missense_Mutation | rs371656613 | c.259C>T | p.Arg87Trp | p.R87W | Q9UL19 | protein_coding | deleterious(0.01) | benign(0.019) | TCGA-AX-A0IZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RARRES3 | SNV | Missense_Mutation | c.45N>T | p.Glu15Asp | p.E15D | Q9UL19 | protein_coding | deleterious(0) | probably_damaging(0.915) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RARRES3 | SNV | Missense_Mutation | novel | c.251N>G | p.Tyr84Cys | p.Y84C | Q9UL19 | protein_coding | tolerated(0.07) | probably_damaging(0.977) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |