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Gene: RABGAP1 |
Gene summary for RABGAP1 |
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Gene information | Species | Human | Gene symbol | RABGAP1 | Gene ID | 23637 |
Gene name | RAB GTPase activating protein 1 | |
Gene Alias | GAPCENA | |
Cytomap | 9q33.2-q33.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9Y3P9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23637 | RABGAP1 | P21T-E | Human | Esophagus | ESCC | 5.71e-28 | 3.60e-01 | 0.1617 |
23637 | RABGAP1 | P22T-E | Human | Esophagus | ESCC | 2.76e-13 | 1.10e-01 | 0.1236 |
23637 | RABGAP1 | P23T-E | Human | Esophagus | ESCC | 2.64e-14 | 2.53e-01 | 0.108 |
23637 | RABGAP1 | P24T-E | Human | Esophagus | ESCC | 7.58e-10 | 2.19e-01 | 0.1287 |
23637 | RABGAP1 | P26T-E | Human | Esophagus | ESCC | 2.04e-13 | 3.28e-01 | 0.1276 |
23637 | RABGAP1 | P27T-E | Human | Esophagus | ESCC | 5.42e-20 | 3.82e-01 | 0.1055 |
23637 | RABGAP1 | P28T-E | Human | Esophagus | ESCC | 2.90e-13 | 2.25e-01 | 0.1149 |
23637 | RABGAP1 | P30T-E | Human | Esophagus | ESCC | 2.27e-21 | 8.61e-01 | 0.137 |
23637 | RABGAP1 | P31T-E | Human | Esophagus | ESCC | 5.81e-29 | 4.03e-01 | 0.1251 |
23637 | RABGAP1 | P32T-E | Human | Esophagus | ESCC | 5.63e-14 | 2.53e-01 | 0.1666 |
23637 | RABGAP1 | P36T-E | Human | Esophagus | ESCC | 2.41e-17 | 4.88e-01 | 0.1187 |
23637 | RABGAP1 | P37T-E | Human | Esophagus | ESCC | 5.79e-27 | 3.38e-01 | 0.1371 |
23637 | RABGAP1 | P38T-E | Human | Esophagus | ESCC | 1.13e-04 | 2.03e-01 | 0.127 |
23637 | RABGAP1 | P39T-E | Human | Esophagus | ESCC | 2.34e-12 | 2.24e-01 | 0.0894 |
23637 | RABGAP1 | P40T-E | Human | Esophagus | ESCC | 7.26e-05 | 1.07e-01 | 0.109 |
23637 | RABGAP1 | P42T-E | Human | Esophagus | ESCC | 1.12e-18 | 3.55e-01 | 0.1175 |
23637 | RABGAP1 | P44T-E | Human | Esophagus | ESCC | 1.29e-09 | 2.20e-01 | 0.1096 |
23637 | RABGAP1 | P47T-E | Human | Esophagus | ESCC | 7.06e-17 | 1.28e-01 | 0.1067 |
23637 | RABGAP1 | P48T-E | Human | Esophagus | ESCC | 7.52e-14 | 2.61e-01 | 0.0959 |
23637 | RABGAP1 | P49T-E | Human | Esophagus | ESCC | 5.19e-10 | 6.97e-01 | 0.1768 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00430877 | Cervix | CC | regulation of GTPase activity | 79/2311 | 348/18723 | 4.21e-08 | 2.60e-06 | 79 |
GO:00435476 | Cervix | CC | positive regulation of GTPase activity | 53/2311 | 255/18723 | 8.72e-05 | 1.16e-03 | 53 |
GO:0043087 | Colorectum | AD | regulation of GTPase activity | 110/3918 | 348/18723 | 1.64e-06 | 5.03e-05 | 110 |
GO:0043547 | Colorectum | AD | positive regulation of GTPase activity | 75/3918 | 255/18723 | 7.95e-04 | 7.91e-03 | 75 |
GO:00430871 | Colorectum | SER | regulation of GTPase activity | 77/2897 | 348/18723 | 5.90e-04 | 8.07e-03 | 77 |
GO:00430872 | Colorectum | MSS | regulation of GTPase activity | 101/3467 | 348/18723 | 1.00e-06 | 3.46e-05 | 101 |
GO:00435471 | Colorectum | MSS | positive regulation of GTPase activity | 68/3467 | 255/18723 | 7.97e-04 | 8.38e-03 | 68 |
GO:00430873 | Colorectum | FAP | regulation of GTPase activity | 85/2622 | 348/18723 | 1.20e-07 | 7.68e-06 | 85 |
GO:00435472 | Colorectum | FAP | positive regulation of GTPase activity | 61/2622 | 255/18723 | 1.39e-05 | 3.73e-04 | 61 |
GO:0090630 | Colorectum | FAP | activation of GTPase activity | 27/2622 | 115/18723 | 4.23e-03 | 2.90e-02 | 27 |
GO:00430874 | Colorectum | CRC | regulation of GTPase activity | 69/2078 | 348/18723 | 1.11e-06 | 6.69e-05 | 69 |
GO:00435473 | Colorectum | CRC | positive regulation of GTPase activity | 49/2078 | 255/18723 | 8.67e-05 | 1.77e-03 | 49 |
GO:00430878 | Endometrium | AEH | regulation of GTPase activity | 66/2100 | 348/18723 | 1.26e-05 | 2.77e-04 | 66 |
GO:00435477 | Endometrium | AEH | positive regulation of GTPase activity | 48/2100 | 255/18723 | 2.18e-04 | 2.67e-03 | 48 |
GO:00906304 | Endometrium | AEH | activation of GTPase activity | 22/2100 | 115/18723 | 8.42e-03 | 4.60e-02 | 22 |
GO:004308712 | Endometrium | EEC | regulation of GTPase activity | 67/2168 | 348/18723 | 1.84e-05 | 3.43e-04 | 67 |
GO:004354712 | Endometrium | EEC | positive regulation of GTPase activity | 50/2168 | 255/18723 | 1.26e-04 | 1.66e-03 | 50 |
GO:009063012 | Endometrium | EEC | activation of GTPase activity | 23/2168 | 115/18723 | 6.04e-03 | 3.57e-02 | 23 |
GO:004308715 | Esophagus | ESCC | regulation of GTPase activity | 183/8552 | 348/18723 | 5.34e-03 | 2.00e-02 | 183 |
GO:00430875 | Liver | NAFLD | regulation of GTPase activity | 62/1882 | 348/18723 | 5.65e-06 | 2.03e-04 | 62 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RABGAP1 | SNV | Missense_Mutation | novel | c.352N>A | p.Glu118Lys | p.E118K | Q9Y3P9 | protein_coding | tolerated(0.71) | benign(0.014) | TCGA-AC-A23G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | CR |
RABGAP1 | SNV | Missense_Mutation | c.496N>A | p.Glu166Lys | p.E166K | Q9Y3P9 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
RABGAP1 | SNV | Missense_Mutation | novel | c.1356N>A | p.Phe452Leu | p.F452L | Q9Y3P9 | protein_coding | deleterious(0.01) | probably_damaging(0.917) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RABGAP1 | SNV | Missense_Mutation | c.1483N>T | p.Arg495Cys | p.R495C | Q9Y3P9 | protein_coding | tolerated(0.06) | benign(0.003) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RABGAP1 | SNV | Missense_Mutation | novel | c.3143N>T | p.Thr1048Met | p.T1048M | Q9Y3P9 | protein_coding | deleterious(0) | possibly_damaging(0.818) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RABGAP1 | SNV | Missense_Mutation | c.560N>T | p.Ser187Leu | p.S187L | Q9Y3P9 | protein_coding | tolerated(0.59) | benign(0.268) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
RABGAP1 | SNV | Missense_Mutation | c.1967N>T | p.Ala656Val | p.A656V | Q9Y3P9 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
RABGAP1 | SNV | Missense_Mutation | c.3018G>T | p.Gln1006His | p.Q1006H | Q9Y3P9 | protein_coding | tolerated(0.07) | benign(0.01) | TCGA-AA-3844-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD | |
RABGAP1 | SNV | Missense_Mutation | novel | c.1231N>A | p.Val411Ile | p.V411I | Q9Y3P9 | protein_coding | deleterious(0.04) | benign(0.134) | TCGA-AA-3851-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
RABGAP1 | SNV | Missense_Mutation | c.170A>C | p.Glu57Ala | p.E57A | Q9Y3P9 | protein_coding | tolerated(0.1) | possibly_damaging(0.551) | TCGA-AA-A004-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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