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Gene: PXMP2 |
Gene summary for PXMP2 |
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Gene information | Species | Human | Gene symbol | PXMP2 | Gene ID | 5827 |
Gene name | peroxisomal membrane protein 2 | |
Gene Alias | MPV17L3 | |
Cytomap | 12q24.33 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q9NR77 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5827 | PXMP2 | HCC2_Meng | Human | Liver | HCC | 3.72e-09 | -1.38e-01 | 0.0107 |
5827 | PXMP2 | cirrhotic1 | Human | Liver | Cirrhotic | 5.43e-11 | 2.10e-01 | 0.0202 |
5827 | PXMP2 | cirrhotic2 | Human | Liver | Cirrhotic | 6.90e-11 | 2.03e-01 | 0.0201 |
5827 | PXMP2 | cirrhotic3 | Human | Liver | Cirrhotic | 3.18e-06 | 1.14e-01 | 0.0215 |
5827 | PXMP2 | HCC1 | Human | Liver | HCC | 1.47e-12 | 4.85e+00 | 0.5336 |
5827 | PXMP2 | HCC2 | Human | Liver | HCC | 9.38e-33 | 4.61e+00 | 0.5341 |
5827 | PXMP2 | Pt13.b | Human | Liver | HCC | 5.30e-14 | 1.72e-01 | 0.0251 |
5827 | PXMP2 | Pt14.b | Human | Liver | HCC | 3.68e-05 | 2.73e-01 | 0.018 |
5827 | PXMP2 | S014 | Human | Liver | HCC | 1.28e-20 | 9.92e-01 | 0.2254 |
5827 | PXMP2 | S015 | Human | Liver | HCC | 2.40e-09 | 8.32e-01 | 0.2375 |
5827 | PXMP2 | S016 | Human | Liver | HCC | 1.07e-14 | 7.36e-01 | 0.2243 |
5827 | PXMP2 | S027 | Human | Liver | HCC | 1.12e-07 | 1.09e+00 | 0.2446 |
5827 | PXMP2 | S028 | Human | Liver | HCC | 6.29e-29 | 1.46e+00 | 0.2503 |
5827 | PXMP2 | S029 | Human | Liver | HCC | 5.95e-24 | 1.58e+00 | 0.2581 |
5827 | PXMP2 | C04 | Human | Oral cavity | OSCC | 2.10e-22 | 1.15e+00 | 0.2633 |
5827 | PXMP2 | C21 | Human | Oral cavity | OSCC | 8.28e-45 | 1.70e+00 | 0.2678 |
5827 | PXMP2 | C30 | Human | Oral cavity | OSCC | 1.04e-32 | 1.65e+00 | 0.3055 |
5827 | PXMP2 | C43 | Human | Oral cavity | OSCC | 3.06e-30 | 6.11e-01 | 0.1704 |
5827 | PXMP2 | C46 | Human | Oral cavity | OSCC | 3.49e-28 | 9.15e-01 | 0.1673 |
5827 | PXMP2 | C51 | Human | Oral cavity | OSCC | 1.03e-16 | 1.03e+00 | 0.2674 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa041467 | Esophagus | ESCC | Peroxisome | 55/4205 | 82/8465 | 1.04e-03 | 3.27e-03 | 1.68e-03 | 55 |
hsa0414612 | Esophagus | ESCC | Peroxisome | 55/4205 | 82/8465 | 1.04e-03 | 3.27e-03 | 1.68e-03 | 55 |
hsa041462 | Liver | Cirrhotic | Peroxisome | 36/2530 | 82/8465 | 4.79e-03 | 1.74e-02 | 1.07e-02 | 36 |
hsa041463 | Liver | Cirrhotic | Peroxisome | 36/2530 | 82/8465 | 4.79e-03 | 1.74e-02 | 1.07e-02 | 36 |
hsa041464 | Liver | HCC | Peroxisome | 58/4020 | 82/8465 | 1.57e-05 | 1.05e-04 | 5.85e-05 | 58 |
hsa041465 | Liver | HCC | Peroxisome | 58/4020 | 82/8465 | 1.57e-05 | 1.05e-04 | 5.85e-05 | 58 |
hsa041466 | Oral cavity | OSCC | Peroxisome | 47/3704 | 82/8465 | 9.01e-03 | 2.01e-02 | 1.03e-02 | 47 |
hsa0414611 | Oral cavity | OSCC | Peroxisome | 47/3704 | 82/8465 | 9.01e-03 | 2.01e-02 | 1.03e-02 | 47 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PXMP2 | SNV | Missense_Mutation | novel | c.171N>T | p.Lys57Asn | p.K57N | Q9NR77 | protein_coding | tolerated(0.05) | benign(0.17) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PXMP2 | SNV | Missense_Mutation | c.267C>G | p.Phe89Leu | p.F89L | Q9NR77 | protein_coding | tolerated(0.18) | benign(0.005) | TCGA-MY-A5BE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
PXMP2 | SNV | Missense_Mutation | rs746666562 | c.346G>A | p.Val116Ile | p.V116I | Q9NR77 | protein_coding | tolerated(1) | benign(0.001) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PXMP2 | SNV | Missense_Mutation | rs765325030 | c.340N>T | p.Arg114Cys | p.R114C | Q9NR77 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
PXMP2 | SNV | Missense_Mutation | c.562G>A | p.Ala188Thr | p.A188T | Q9NR77 | protein_coding | tolerated(0.44) | benign(0.027) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
PXMP2 | SNV | Missense_Mutation | rs200781916 | c.176N>A | p.Arg59Gln | p.R59Q | Q9NR77 | protein_coding | tolerated(0.51) | benign(0.005) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PXMP2 | deletion | Frame_Shift_Del | novel | c.178delN | p.Glu62LysfsTer12 | p.E62Kfs*12 | Q9NR77 | protein_coding | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
PXMP2 | SNV | Missense_Mutation | rs746666562 | c.346G>A | p.Val116Ile | p.V116I | Q9NR77 | protein_coding | tolerated(1) | benign(0.001) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PXMP2 | SNV | Missense_Mutation | rs201360859 | c.421G>A | p.Ala141Thr | p.A141T | Q9NR77 | protein_coding | tolerated(0.49) | benign(0.143) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PXMP2 | SNV | Missense_Mutation | novel | c.356N>A | p.Pro119Gln | p.P119Q | Q9NR77 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A0LS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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