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Gene: PRELID3B |
Gene summary for PRELID3B |
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Gene information | Species | Human | Gene symbol | PRELID3B | Gene ID | 51012 |
Gene name | PRELI domain containing 3B | |
Gene Alias | C20orf45 | |
Cytomap | 20q13.32 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9Y3B1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51012 | PRELID3B | P48T-E | Human | Esophagus | ESCC | 7.62e-18 | 4.75e-01 | 0.0959 |
51012 | PRELID3B | P49T-E | Human | Esophagus | ESCC | 5.48e-20 | 2.06e+00 | 0.1768 |
51012 | PRELID3B | P52T-E | Human | Esophagus | ESCC | 5.43e-39 | 1.26e+00 | 0.1555 |
51012 | PRELID3B | P54T-E | Human | Esophagus | ESCC | 3.31e-20 | 6.25e-01 | 0.0975 |
51012 | PRELID3B | P56T-E | Human | Esophagus | ESCC | 1.17e-08 | 1.76e+00 | 0.1613 |
51012 | PRELID3B | P57T-E | Human | Esophagus | ESCC | 1.14e-14 | 4.11e-01 | 0.0926 |
51012 | PRELID3B | P61T-E | Human | Esophagus | ESCC | 8.87e-14 | 5.40e-01 | 0.099 |
51012 | PRELID3B | P62T-E | Human | Esophagus | ESCC | 1.97e-72 | 1.27e+00 | 0.1302 |
51012 | PRELID3B | P65T-E | Human | Esophagus | ESCC | 1.29e-23 | 6.74e-01 | 0.0978 |
51012 | PRELID3B | P74T-E | Human | Esophagus | ESCC | 2.62e-29 | 1.05e+00 | 0.1479 |
51012 | PRELID3B | P75T-E | Human | Esophagus | ESCC | 2.37e-75 | 1.79e+00 | 0.1125 |
51012 | PRELID3B | P76T-E | Human | Esophagus | ESCC | 4.85e-38 | 9.02e-01 | 0.1207 |
51012 | PRELID3B | P79T-E | Human | Esophagus | ESCC | 8.22e-51 | 1.20e+00 | 0.1154 |
51012 | PRELID3B | P80T-E | Human | Esophagus | ESCC | 2.85e-54 | 1.96e+00 | 0.155 |
51012 | PRELID3B | P82T-E | Human | Esophagus | ESCC | 9.99e-18 | 1.38e+00 | 0.1072 |
51012 | PRELID3B | P83T-E | Human | Esophagus | ESCC | 1.83e-51 | 1.59e+00 | 0.1738 |
51012 | PRELID3B | P84T-E | Human | Esophagus | ESCC | 1.18e-08 | 5.33e-01 | 0.0933 |
51012 | PRELID3B | P89T-E | Human | Esophagus | ESCC | 2.53e-24 | 1.89e+00 | 0.1752 |
51012 | PRELID3B | P91T-E | Human | Esophagus | ESCC | 1.67e-16 | 2.31e+00 | 0.1828 |
51012 | PRELID3B | P94T-E | Human | Esophagus | ESCC | 3.48e-03 | 1.33e+00 | 0.0879 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010876 | Colorectum | AD | lipid localization | 120/3918 | 448/18723 | 1.59e-03 | 1.33e-02 | 120 |
GO:0006869 | Colorectum | AD | lipid transport | 108/3918 | 398/18723 | 1.67e-03 | 1.39e-02 | 108 |
GO:0015748 | Colorectum | AD | organophosphate ester transport | 42/3918 | 140/18723 | 7.04e-03 | 4.31e-02 | 42 |
GO:00108761 | Colorectum | MSS | lipid localization | 104/3467 | 448/18723 | 6.76e-03 | 4.38e-02 | 104 |
GO:00068691 | Colorectum | FAP | lipid transport | 81/2622 | 398/18723 | 2.84e-04 | 3.76e-03 | 81 |
GO:00108762 | Colorectum | FAP | lipid localization | 85/2622 | 448/18723 | 1.92e-03 | 1.63e-02 | 85 |
GO:0015914 | Colorectum | FAP | phospholipid transport | 23/2622 | 96/18723 | 6.09e-03 | 3.82e-02 | 23 |
GO:001087611 | Liver | Cirrhotic | lipid localization | 147/4634 | 448/18723 | 6.24e-05 | 7.12e-04 | 147 |
GO:000686911 | Liver | Cirrhotic | lipid transport | 128/4634 | 398/18723 | 4.54e-04 | 3.69e-03 | 128 |
GO:01200091 | Liver | Cirrhotic | intermembrane lipid transfer | 21/4634 | 48/18723 | 3.06e-03 | 1.73e-02 | 21 |
GO:001087621 | Liver | HCC | lipid localization | 228/7958 | 448/18723 | 1.80e-04 | 1.41e-03 | 228 |
GO:01200092 | Liver | HCC | intermembrane lipid transfer | 33/7958 | 48/18723 | 2.12e-04 | 1.63e-03 | 33 |
GO:000686921 | Liver | HCC | lipid transport | 198/7958 | 398/18723 | 1.92e-03 | 9.78e-03 | 198 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PRELID3B | SNV | Missense_Mutation | rs762528766 | c.35A>C | p.His12Pro | p.H12P | Q9Y3B1 | protein_coding | deleterious(0) | possibly_damaging(0.873) | TCGA-A8-A07W-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | exemestane | SD |
PRELID3B | SNV | Missense_Mutation | novel | c.296C>T | p.Ser99Leu | p.S99L | Q9Y3B1 | protein_coding | tolerated(0.05) | benign(0.114) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
PRELID3B | SNV | Missense_Mutation | c.514N>A | p.Glu172Lys | p.E172K | Q9Y3B1 | protein_coding | tolerated(0.38) | benign(0.019) | TCGA-F4-6703-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PRELID3B | SNV | Missense_Mutation | novel | c.506C>T | p.Ala169Val | p.A169V | Q9Y3B1 | protein_coding | tolerated(0.1) | possibly_damaging(0.493) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
PRELID3B | SNV | Missense_Mutation | novel | c.130N>T | p.Asp44Tyr | p.D44Y | Q9Y3B1 | protein_coding | tolerated(0.05) | possibly_damaging(0.634) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PRELID3B | SNV | Missense_Mutation | rs776059070 | c.443N>T | p.Thr148Met | p.T148M | Q9Y3B1 | protein_coding | tolerated(0.07) | possibly_damaging(0.802) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PRELID3B | SNV | Missense_Mutation | c.200C>A | p.Ser67Tyr | p.S67Y | Q9Y3B1 | protein_coding | deleterious(0) | possibly_damaging(0.482) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PRELID3B | SNV | Missense_Mutation | novel | c.307N>G | p.Met103Val | p.M103V | Q9Y3B1 | protein_coding | tolerated(0.22) | benign(0) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PRELID3B | SNV | Missense_Mutation | novel | c.230A>G | p.Tyr77Cys | p.Y77C | Q9Y3B1 | protein_coding | deleterious(0) | possibly_damaging(0.789) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
PRELID3B | SNV | Missense_Mutation | rs376167473 | c.269N>T | p.Thr90Ile | p.T90I | Q9Y3B1 | protein_coding | tolerated(0.11) | benign(0.114) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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