Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact

Center for Computational Systems Medicine
leaf

Gene summary

leaf

Malignant transformation analysis

leaf

Malignant transformation related pathway analysis

leaf

Cell-cell communication analysis

leaf

Single-cell gene regulatory network inference analysis

leaf

Somatic mutation of malignant transformation related genes

leaf

Related drugs of malignant transformation related genes

Gene: PPP2CB

Gene summary for PPP2CB

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

PPP2CB

Gene ID

5516

Gene nameprotein phosphatase 2 catalytic subunit beta
Gene AliasPP2Abeta
Cytomap8p12
Gene Typeprotein-coding
GO ID

GO:0000302

UniProtAcc

A0A140VJS0


Top

Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
5516PPP2CB052097_1595-all-cellsHumanProstateBPH1.02e-043.22e-010.0972
5516PPP2CBDong_P1HumanProstateTumor3.82e-20-2.55e-030.035
5516PPP2CBDong_P3HumanProstateTumor3.19e-13-9.42e-030.0278
5516PPP2CBDong_P4HumanProstateTumor2.51e-03-1.60e-010.0292
5516PPP2CBDong_P5HumanProstateTumor9.36e-29-1.34e-010.053
5516PPP2CBGSM5353243_PA_PR5261_T1_S23_L002HumanProstateTumor1.73e-07-2.62e-020.1545
5516PPP2CBP1_S1_AKHumanSkinAK4.71e-174.89e-01-0.3399
5516PPP2CBP2_S3_AKHumanSkinAK2.06e-104.32e-01-0.3287
5516PPP2CBP2_S4_SCCISHumanSkinSCCIS2.50e-074.06e-01-0.3043
5516PPP2CBP4_S8_cSCCHumanSkincSCC7.24e-113.97e-01-0.3095
5516PPP2CBP5_S10_cSCCHumanSkincSCC2.92e-112.73e-01-0.299
5516PPP2CBP1_cSCCHumanSkincSCC5.55e-166.70e-010.0292
5516PPP2CBP2_cSCCHumanSkincSCC3.10e-083.69e-01-0.024
5516PPP2CBP4_cSCCHumanSkincSCC1.31e-074.25e-01-0.00290000000000005
5516PPP2CBP10_cSCCHumanSkincSCC1.13e-207.53e-010.1017
5516PPP2CBcSCC_p8HumanSkincSCC8.76e-033.58e-02-0.1971
5516PPP2CBAdj_PTCwithHT_6HumanThyroidHT8.28e-20-7.26e-010.02
5516PPP2CBAdj_PTCwithHT_8HumanThyroidHT1.31e-11-6.64e-010.0267
5516PPP2CBPTCwithHT_1HumanThyroidHT4.71e-07-7.42e-010.0238
5516PPP2CBPTCwithHT_6HumanThyroidHT1.84e-17-7.06e-010.02
Page: 1 2 3 4 5 

check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
Page: 1 2 3 4 5 6 7 8 9 

check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0010498ColorectumADproteasomal protein catabolic process174/3918490/187233.18e-147.66e-12174
GO:0043161ColorectumADproteasome-mediated ubiquitin-dependent protein catabolic process141/3918412/187231.77e-101.68e-08141
GO:0051098ColorectumADregulation of binding126/3918363/187236.01e-104.88e-08126
GO:0006979ColorectumADresponse to oxidative stress145/3918446/187235.16e-093.23e-07145
GO:0034976ColorectumADresponse to endoplasmic reticulum stress90/3918256/187238.48e-084.28e-0690
GO:0051099ColorectumADpositive regulation of binding66/3918173/187231.47e-076.64e-0666
GO:0000302ColorectumADresponse to reactive oxygen species78/3918222/187236.17e-072.21e-0578
GO:0043393ColorectumADregulation of protein binding68/3918196/187235.17e-061.34e-0468
GO:0007265ColorectumADRas protein signal transduction104/3918337/187231.01e-052.35e-04104
GO:0008637ColorectumADapoptotic mitochondrial changes42/3918107/187231.13e-052.56e-0442
GO:0051056ColorectumADregulation of small GTPase mediated signal transduction94/3918302/187231.81e-053.76e-0494
GO:0016311ColorectumADdephosphorylation123/3918417/187231.84e-053.82e-04123
GO:0006470ColorectumADprotein dephosphorylation88/3918281/187232.56e-054.89e-0488
GO:0042542ColorectumADresponse to hydrogen peroxide52/3918146/187232.83e-055.30e-0452
GO:0032092ColorectumADpositive regulation of protein binding33/391885/187231.22e-041.78e-0333
GO:0010038ColorectumADresponse to metal ion106/3918373/187233.22e-043.83e-03106
GO:0046578ColorectumADregulation of Ras protein signal transduction56/3918189/187232.85e-032.14e-0256
GO:0051058ColorectumADnegative regulation of small GTPase mediated signal transduction21/391856/187233.26e-032.39e-0221
GO:00104981ColorectumSERproteasomal protein catabolic process132/2897490/187233.08e-115.55e-09132
GO:00069791ColorectumSERresponse to oxidative stress114/2897446/187231.75e-081.28e-06114
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 

check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa04530ColorectumADTight junction76/2092169/84655.49e-099.69e-086.18e-0876
hsa04152ColorectumADAMPK signaling pathway47/2092121/84653.74e-042.82e-031.80e-0347
hsa05160ColorectumADHepatitis C54/2092157/84653.87e-031.96e-021.25e-0254
hsa04140ColorectumADAutophagy - animal49/2092141/84654.58e-032.20e-021.40e-0249
hsa04071ColorectumADSphingolipid signaling pathway43/2092121/84654.83e-032.28e-021.45e-0243
hsa04728ColorectumADDopaminergic synapse46/2092132/84655.55e-032.48e-021.58e-0246
hsa03015ColorectumADmRNA surveillance pathway35/209297/84657.95e-033.13e-022.00e-0235
hsa045301ColorectumADTight junction76/2092169/84655.49e-099.69e-086.18e-0876
hsa041521ColorectumADAMPK signaling pathway47/2092121/84653.74e-042.82e-031.80e-0347
hsa051601ColorectumADHepatitis C54/2092157/84653.87e-031.96e-021.25e-0254
hsa041401ColorectumADAutophagy - animal49/2092141/84654.58e-032.20e-021.40e-0249
hsa040711ColorectumADSphingolipid signaling pathway43/2092121/84654.83e-032.28e-021.45e-0243
hsa047281ColorectumADDopaminergic synapse46/2092132/84655.55e-032.48e-021.58e-0246
hsa030151ColorectumADmRNA surveillance pathway35/209297/84657.95e-033.13e-022.00e-0235
hsa045302ColorectumSERTight junction59/1580169/84653.24e-075.98e-064.34e-0659
hsa047282ColorectumSERDopaminergic synapse37/1580132/84655.27e-033.28e-022.38e-0237
hsa041402ColorectumSERAutophagy - animal39/1580141/84655.43e-033.28e-022.38e-0239
hsa04350ColorectumSERTGF-beta signaling pathway31/1580108/84657.00e-033.77e-022.74e-0231
hsa045303ColorectumSERTight junction59/1580169/84653.24e-075.98e-064.34e-0659
hsa047283ColorectumSERDopaminergic synapse37/1580132/84655.27e-033.28e-022.38e-0237
Page: 1 2 3 4 5 6 7 8 9 10 

Top

Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
Page: 1 

Top

Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
Page: 1 

Top

Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
PPP2CBSNVMissense_Mutationnovelc.926T>Gp.Leu309Argp.L309RP62714protein_codingdeleterious(0)possibly_damaging(0.853)TCGA-AC-A6IW-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
PPP2CBSNVMissense_Mutationc.687N>Ap.Asn229Lysp.N229KP62714protein_codingtolerated(0.06)possibly_damaging(0.803)TCGA-B6-A0IJ-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
PPP2CBSNVMissense_Mutationc.715C>Tp.Arg239Cysp.R239CP62714protein_codingdeleterious(0)probably_damaging(1)TCGA-BH-A0DS-01Breastbreast invasive carcinomaFemale>=65III/IVChemotherapycyclophosphamideSD
PPP2CBSNVMissense_Mutationc.229N>Tp.Asp77Tyrp.D77YP62714protein_codingtolerated(0.05)benign(0.235)TCGA-D8-A147-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicineSD
PPP2CBSNVMissense_Mutationc.803N>Ap.Arg268Hisp.R268HP62714protein_codingtolerated(0.06)possibly_damaging(0.85)TCGA-D8-A1Y1-01Breastbreast invasive carcinomaFemale>=65III/IVHormone TherapytamoxiphenPD
PPP2CBinsertionFrame_Shift_Insnovelc.459_460insAAp.Pro154AsnfsTer6p.P154Nfs*6P62714protein_codingTCGA-BH-A0B4-01Breastbreast invasive carcinomaMale>=65III/IVHormone TherapytamoxiphenSD
PPP2CBinsertionNonsense_Mutationnovelc.458_459insGTAATGACAGCTGGGTACAGTGGCATGCACCTGp.Leu153_Pro154insTerp.L153_P154ins*P62714protein_codingTCGA-BH-A0B4-01Breastbreast invasive carcinomaMale>=65III/IVHormone TherapytamoxiphenSD
PPP2CBSNVMissense_Mutationc.733N>Gp.Met245Valp.M245VP62714protein_codingdeleterious(0.01)benign(0.048)TCGA-A6-5665-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownPD
PPP2CBSNVMissense_Mutationrs771311551c.145N>Tp.Arg49Cysp.R49CP62714protein_codingdeleterious(0.03)benign(0.238)TCGA-AA-3984-01Colorectumcolon adenocarcinomaFemale<65I/IIUnknownUnknownSD
PPP2CBSNVMissense_Mutationc.467N>Tp.Thr156Ilep.T156IP62714protein_codingdeleterious(0)probably_damaging(0.955)TCGA-AY-6197-01Colorectumcolon adenocarcinomaMale<65I/IIUnknownUnknownSD
Page: 1 2 3 

Top

Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
Page: 1