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Gene: PPP2CB |
Gene summary for PPP2CB |
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Gene information | Species | Human | Gene symbol | PPP2CB | Gene ID | 5516 |
Gene name | protein phosphatase 2 catalytic subunit beta | |
Gene Alias | PP2Abeta | |
Cytomap | 8p12 | |
Gene Type | protein-coding | GO ID | GO:0000302 | UniProtAcc | A0A140VJS0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5516 | PPP2CB | 052097_1595-all-cells | Human | Prostate | BPH | 1.02e-04 | 3.22e-01 | 0.0972 |
5516 | PPP2CB | Dong_P1 | Human | Prostate | Tumor | 3.82e-20 | -2.55e-03 | 0.035 |
5516 | PPP2CB | Dong_P3 | Human | Prostate | Tumor | 3.19e-13 | -9.42e-03 | 0.0278 |
5516 | PPP2CB | Dong_P4 | Human | Prostate | Tumor | 2.51e-03 | -1.60e-01 | 0.0292 |
5516 | PPP2CB | Dong_P5 | Human | Prostate | Tumor | 9.36e-29 | -1.34e-01 | 0.053 |
5516 | PPP2CB | GSM5353243_PA_PR5261_T1_S23_L002 | Human | Prostate | Tumor | 1.73e-07 | -2.62e-02 | 0.1545 |
5516 | PPP2CB | P1_S1_AK | Human | Skin | AK | 4.71e-17 | 4.89e-01 | -0.3399 |
5516 | PPP2CB | P2_S3_AK | Human | Skin | AK | 2.06e-10 | 4.32e-01 | -0.3287 |
5516 | PPP2CB | P2_S4_SCCIS | Human | Skin | SCCIS | 2.50e-07 | 4.06e-01 | -0.3043 |
5516 | PPP2CB | P4_S8_cSCC | Human | Skin | cSCC | 7.24e-11 | 3.97e-01 | -0.3095 |
5516 | PPP2CB | P5_S10_cSCC | Human | Skin | cSCC | 2.92e-11 | 2.73e-01 | -0.299 |
5516 | PPP2CB | P1_cSCC | Human | Skin | cSCC | 5.55e-16 | 6.70e-01 | 0.0292 |
5516 | PPP2CB | P2_cSCC | Human | Skin | cSCC | 3.10e-08 | 3.69e-01 | -0.024 |
5516 | PPP2CB | P4_cSCC | Human | Skin | cSCC | 1.31e-07 | 4.25e-01 | -0.00290000000000005 |
5516 | PPP2CB | P10_cSCC | Human | Skin | cSCC | 1.13e-20 | 7.53e-01 | 0.1017 |
5516 | PPP2CB | cSCC_p8 | Human | Skin | cSCC | 8.76e-03 | 3.58e-02 | -0.1971 |
5516 | PPP2CB | Adj_PTCwithHT_6 | Human | Thyroid | HT | 8.28e-20 | -7.26e-01 | 0.02 |
5516 | PPP2CB | Adj_PTCwithHT_8 | Human | Thyroid | HT | 1.31e-11 | -6.64e-01 | 0.0267 |
5516 | PPP2CB | PTCwithHT_1 | Human | Thyroid | HT | 4.71e-07 | -7.42e-01 | 0.0238 |
5516 | PPP2CB | PTCwithHT_6 | Human | Thyroid | HT | 1.84e-17 | -7.06e-01 | 0.02 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010498 | Colorectum | AD | proteasomal protein catabolic process | 174/3918 | 490/18723 | 3.18e-14 | 7.66e-12 | 174 |
GO:0043161 | Colorectum | AD | proteasome-mediated ubiquitin-dependent protein catabolic process | 141/3918 | 412/18723 | 1.77e-10 | 1.68e-08 | 141 |
GO:0051098 | Colorectum | AD | regulation of binding | 126/3918 | 363/18723 | 6.01e-10 | 4.88e-08 | 126 |
GO:0006979 | Colorectum | AD | response to oxidative stress | 145/3918 | 446/18723 | 5.16e-09 | 3.23e-07 | 145 |
GO:0034976 | Colorectum | AD | response to endoplasmic reticulum stress | 90/3918 | 256/18723 | 8.48e-08 | 4.28e-06 | 90 |
GO:0051099 | Colorectum | AD | positive regulation of binding | 66/3918 | 173/18723 | 1.47e-07 | 6.64e-06 | 66 |
GO:0000302 | Colorectum | AD | response to reactive oxygen species | 78/3918 | 222/18723 | 6.17e-07 | 2.21e-05 | 78 |
GO:0043393 | Colorectum | AD | regulation of protein binding | 68/3918 | 196/18723 | 5.17e-06 | 1.34e-04 | 68 |
GO:0007265 | Colorectum | AD | Ras protein signal transduction | 104/3918 | 337/18723 | 1.01e-05 | 2.35e-04 | 104 |
GO:0008637 | Colorectum | AD | apoptotic mitochondrial changes | 42/3918 | 107/18723 | 1.13e-05 | 2.56e-04 | 42 |
GO:0051056 | Colorectum | AD | regulation of small GTPase mediated signal transduction | 94/3918 | 302/18723 | 1.81e-05 | 3.76e-04 | 94 |
GO:0016311 | Colorectum | AD | dephosphorylation | 123/3918 | 417/18723 | 1.84e-05 | 3.82e-04 | 123 |
GO:0006470 | Colorectum | AD | protein dephosphorylation | 88/3918 | 281/18723 | 2.56e-05 | 4.89e-04 | 88 |
GO:0042542 | Colorectum | AD | response to hydrogen peroxide | 52/3918 | 146/18723 | 2.83e-05 | 5.30e-04 | 52 |
GO:0032092 | Colorectum | AD | positive regulation of protein binding | 33/3918 | 85/18723 | 1.22e-04 | 1.78e-03 | 33 |
GO:0010038 | Colorectum | AD | response to metal ion | 106/3918 | 373/18723 | 3.22e-04 | 3.83e-03 | 106 |
GO:0046578 | Colorectum | AD | regulation of Ras protein signal transduction | 56/3918 | 189/18723 | 2.85e-03 | 2.14e-02 | 56 |
GO:0051058 | Colorectum | AD | negative regulation of small GTPase mediated signal transduction | 21/3918 | 56/18723 | 3.26e-03 | 2.39e-02 | 21 |
GO:00104981 | Colorectum | SER | proteasomal protein catabolic process | 132/2897 | 490/18723 | 3.08e-11 | 5.55e-09 | 132 |
GO:00069791 | Colorectum | SER | response to oxidative stress | 114/2897 | 446/18723 | 1.75e-08 | 1.28e-06 | 114 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04530 | Colorectum | AD | Tight junction | 76/2092 | 169/8465 | 5.49e-09 | 9.69e-08 | 6.18e-08 | 76 |
hsa04152 | Colorectum | AD | AMPK signaling pathway | 47/2092 | 121/8465 | 3.74e-04 | 2.82e-03 | 1.80e-03 | 47 |
hsa05160 | Colorectum | AD | Hepatitis C | 54/2092 | 157/8465 | 3.87e-03 | 1.96e-02 | 1.25e-02 | 54 |
hsa04140 | Colorectum | AD | Autophagy - animal | 49/2092 | 141/8465 | 4.58e-03 | 2.20e-02 | 1.40e-02 | 49 |
hsa04071 | Colorectum | AD | Sphingolipid signaling pathway | 43/2092 | 121/8465 | 4.83e-03 | 2.28e-02 | 1.45e-02 | 43 |
hsa04728 | Colorectum | AD | Dopaminergic synapse | 46/2092 | 132/8465 | 5.55e-03 | 2.48e-02 | 1.58e-02 | 46 |
hsa03015 | Colorectum | AD | mRNA surveillance pathway | 35/2092 | 97/8465 | 7.95e-03 | 3.13e-02 | 2.00e-02 | 35 |
hsa045301 | Colorectum | AD | Tight junction | 76/2092 | 169/8465 | 5.49e-09 | 9.69e-08 | 6.18e-08 | 76 |
hsa041521 | Colorectum | AD | AMPK signaling pathway | 47/2092 | 121/8465 | 3.74e-04 | 2.82e-03 | 1.80e-03 | 47 |
hsa051601 | Colorectum | AD | Hepatitis C | 54/2092 | 157/8465 | 3.87e-03 | 1.96e-02 | 1.25e-02 | 54 |
hsa041401 | Colorectum | AD | Autophagy - animal | 49/2092 | 141/8465 | 4.58e-03 | 2.20e-02 | 1.40e-02 | 49 |
hsa040711 | Colorectum | AD | Sphingolipid signaling pathway | 43/2092 | 121/8465 | 4.83e-03 | 2.28e-02 | 1.45e-02 | 43 |
hsa047281 | Colorectum | AD | Dopaminergic synapse | 46/2092 | 132/8465 | 5.55e-03 | 2.48e-02 | 1.58e-02 | 46 |
hsa030151 | Colorectum | AD | mRNA surveillance pathway | 35/2092 | 97/8465 | 7.95e-03 | 3.13e-02 | 2.00e-02 | 35 |
hsa045302 | Colorectum | SER | Tight junction | 59/1580 | 169/8465 | 3.24e-07 | 5.98e-06 | 4.34e-06 | 59 |
hsa047282 | Colorectum | SER | Dopaminergic synapse | 37/1580 | 132/8465 | 5.27e-03 | 3.28e-02 | 2.38e-02 | 37 |
hsa041402 | Colorectum | SER | Autophagy - animal | 39/1580 | 141/8465 | 5.43e-03 | 3.28e-02 | 2.38e-02 | 39 |
hsa04350 | Colorectum | SER | TGF-beta signaling pathway | 31/1580 | 108/8465 | 7.00e-03 | 3.77e-02 | 2.74e-02 | 31 |
hsa045303 | Colorectum | SER | Tight junction | 59/1580 | 169/8465 | 3.24e-07 | 5.98e-06 | 4.34e-06 | 59 |
hsa047283 | Colorectum | SER | Dopaminergic synapse | 37/1580 | 132/8465 | 5.27e-03 | 3.28e-02 | 2.38e-02 | 37 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PPP2CB | SNV | Missense_Mutation | novel | c.926T>G | p.Leu309Arg | p.L309R | P62714 | protein_coding | deleterious(0) | possibly_damaging(0.853) | TCGA-AC-A6IW-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPP2CB | SNV | Missense_Mutation | c.687N>A | p.Asn229Lys | p.N229K | P62714 | protein_coding | tolerated(0.06) | possibly_damaging(0.803) | TCGA-B6-A0IJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PPP2CB | SNV | Missense_Mutation | c.715C>T | p.Arg239Cys | p.R239C | P62714 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A0DS-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cyclophosphamide | SD | |
PPP2CB | SNV | Missense_Mutation | c.229N>T | p.Asp77Tyr | p.D77Y | P62714 | protein_coding | tolerated(0.05) | benign(0.235) | TCGA-D8-A147-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD | |
PPP2CB | SNV | Missense_Mutation | c.803N>A | p.Arg268His | p.R268H | P62714 | protein_coding | tolerated(0.06) | possibly_damaging(0.85) | TCGA-D8-A1Y1-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | PD | |
PPP2CB | insertion | Frame_Shift_Ins | novel | c.459_460insAA | p.Pro154AsnfsTer6 | p.P154Nfs*6 | P62714 | protein_coding | TCGA-BH-A0B4-01 | Breast | breast invasive carcinoma | Male | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD | ||
PPP2CB | insertion | Nonsense_Mutation | novel | c.458_459insGTAATGACAGCTGGGTACAGTGGCATGCACCTG | p.Leu153_Pro154insTer | p.L153_P154ins* | P62714 | protein_coding | TCGA-BH-A0B4-01 | Breast | breast invasive carcinoma | Male | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD | ||
PPP2CB | SNV | Missense_Mutation | c.733N>G | p.Met245Val | p.M245V | P62714 | protein_coding | deleterious(0.01) | benign(0.048) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PPP2CB | SNV | Missense_Mutation | rs771311551 | c.145N>T | p.Arg49Cys | p.R49C | P62714 | protein_coding | deleterious(0.03) | benign(0.238) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PPP2CB | SNV | Missense_Mutation | c.467N>T | p.Thr156Ile | p.T156I | P62714 | protein_coding | deleterious(0) | probably_damaging(0.955) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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