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Gene: PPM1K |
Gene summary for PPM1K |
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Gene information | Species | Human | Gene symbol | PPM1K | Gene ID | 152926 |
Gene name | protein phosphatase, Mg2+/Mn2+ dependent 1K | |
Gene Alias | BDP | |
Cytomap | 4q22.1 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q8N3J5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
152926 | PPM1K | PTC07 | Human | Thyroid | PTC | 1.66e-25 | 6.15e-01 | 0.2044 |
152926 | PPM1K | ATC09 | Human | Thyroid | ATC | 3.16e-08 | 2.16e-01 | 0.2871 |
152926 | PPM1K | ATC12 | Human | Thyroid | ATC | 7.06e-05 | 1.18e-01 | 0.34 |
152926 | PPM1K | ATC13 | Human | Thyroid | ATC | 3.78e-21 | 9.97e-02 | 0.34 |
152926 | PPM1K | ATC1 | Human | Thyroid | ATC | 2.05e-09 | 2.74e-01 | 0.2878 |
152926 | PPM1K | ATC2 | Human | Thyroid | ATC | 7.49e-04 | 5.82e-01 | 0.34 |
152926 | PPM1K | ATC3 | Human | Thyroid | ATC | 1.57e-03 | 1.31e-01 | 0.338 |
152926 | PPM1K | ATC4 | Human | Thyroid | ATC | 2.06e-05 | 2.25e-01 | 0.34 |
152926 | PPM1K | ATC5 | Human | Thyroid | ATC | 3.25e-18 | 1.35e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001631110 | Esophagus | ESCC | dephosphorylation | 251/8552 | 417/18723 | 1.26e-09 | 2.99e-08 | 251 |
GO:000647018 | Esophagus | ESCC | protein dephosphorylation | 177/8552 | 281/18723 | 3.13e-09 | 6.72e-08 | 177 |
GO:001631121 | Liver | HCC | dephosphorylation | 230/7958 | 417/18723 | 1.00e-07 | 1.96e-06 | 230 |
GO:000647021 | Liver | HCC | protein dephosphorylation | 162/7958 | 281/18723 | 1.91e-07 | 3.46e-06 | 162 |
GO:000647014 | Prostate | Tumor | protein dephosphorylation | 76/3246 | 281/18723 | 2.86e-05 | 3.46e-04 | 76 |
GO:001631113 | Prostate | Tumor | dephosphorylation | 98/3246 | 417/18723 | 7.31e-04 | 5.08e-03 | 98 |
GO:001631116 | Thyroid | PTC | dephosphorylation | 174/5968 | 417/18723 | 1.20e-05 | 1.31e-04 | 174 |
GO:000647020 | Thyroid | PTC | protein dephosphorylation | 123/5968 | 281/18723 | 1.69e-05 | 1.77e-04 | 123 |
GO:0006470111 | Thyroid | ATC | protein dephosphorylation | 129/6293 | 281/18723 | 1.11e-05 | 1.09e-04 | 129 |
GO:001631117 | Thyroid | ATC | dephosphorylation | 179/6293 | 417/18723 | 3.88e-05 | 3.15e-04 | 179 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PPM1K | SNV | Missense_Mutation | novel | c.714G>T | p.Lys238Asn | p.K238N | Q8N3J5 | protein_coding | deleterious(0.03) | benign(0.384) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PPM1K | SNV | Missense_Mutation | novel | c.896G>A | p.Gly299Glu | p.G299E | Q8N3J5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PPM1K | SNV | Missense_Mutation | novel | c.859N>T | p.His287Tyr | p.H287Y | Q8N3J5 | protein_coding | deleterious(0) | probably_damaging(0.934) | TCGA-ZJ-AAX8-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
PPM1K | SNV | Missense_Mutation | rs370483637 | c.515N>T | p.Ser172Leu | p.S172L | Q8N3J5 | protein_coding | tolerated(0.28) | benign(0.109) | TCGA-AA-3502-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PPM1K | SNV | Missense_Mutation | rs753095031 | c.146G>A | p.Arg49Gln | p.R49Q | Q8N3J5 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.788) | TCGA-AA-3870-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folinic | CR |
PPM1K | SNV | Missense_Mutation | rs537053098 | c.110N>T | p.Thr37Met | p.T37M | Q8N3J5 | protein_coding | tolerated_low_confidence(0.1) | benign(0.108) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PPM1K | SNV | Missense_Mutation | rs146041562 | c.209G>A | p.Arg70His | p.R70H | Q8N3J5 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
PPM1K | insertion | Frame_Shift_Ins | novel | c.750dupG | p.Gln251AlafsTer20 | p.Q251Afs*20 | Q8N3J5 | protein_coding | TCGA-DM-A0XD-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
PPM1K | SNV | Missense_Mutation | novel | c.917N>T | p.Ser306Ile | p.S306I | Q8N3J5 | protein_coding | deleterious(0.01) | possibly_damaging(0.687) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
PPM1K | SNV | Missense_Mutation | c.14N>T | p.Ala5Val | p.A5V | Q8N3J5 | protein_coding | tolerated_low_confidence(1) | benign(0.015) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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