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Gene: PPDPF |
Gene summary for PPDPF |
Gene summary. |
Gene information | Species | Human | Gene symbol | PPDPF | Gene ID | 79144 |
Gene name | pancreatic progenitor cell differentiation and proliferation factor | |
Gene Alias | C20orf149 | |
Cytomap | 20q13.33 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q9H3Y8 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79144 | PPDPF | HTA11_546_2000001011 | Human | Colorectum | AD | 3.29e-07 | 6.13e-01 | -0.0842 |
79144 | PPDPF | HTA11_866_3004761011 | Human | Colorectum | AD | 8.96e-03 | 1.29e-01 | 0.096 |
79144 | PPDPF | HTA11_9408_2000001011 | Human | Colorectum | AD | 2.64e-07 | 1.03e+00 | 0.0451 |
79144 | PPDPF | HTA11_10623_2000001011 | Human | Colorectum | AD | 2.12e-22 | 1.23e+00 | -0.0177 |
79144 | PPDPF | HTA11_6801_2000001011 | Human | Colorectum | SER | 6.18e-05 | 8.31e-01 | 0.0171 |
79144 | PPDPF | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.04e-27 | 1.04e+00 | 0.0338 |
79144 | PPDPF | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.65e-31 | 9.89e-01 | 0.0674 |
79144 | PPDPF | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.95e-06 | 6.91e-01 | 0.0112 |
79144 | PPDPF | HTA11_7469_2000001011 | Human | Colorectum | AD | 2.11e-06 | 1.16e+00 | -0.0124 |
79144 | PPDPF | HTA11_6818_2000001021 | Human | Colorectum | AD | 7.74e-05 | 5.55e-01 | 0.0588 |
79144 | PPDPF | HTA11_99999971662_82457 | Human | Colorectum | MSS | 7.56e-28 | 9.17e-01 | 0.3859 |
79144 | PPDPF | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.68e-23 | 8.20e-01 | 0.3005 |
79144 | PPDPF | A002-C-203 | Human | Colorectum | FAP | 8.98e-03 | 3.80e-01 | 0.2786 |
79144 | PPDPF | F034 | Human | Colorectum | FAP | 2.06e-02 | -1.61e-01 | -0.0665 |
79144 | PPDPF | CRC-1-8810 | Human | Colorectum | CRC | 3.34e-16 | 7.23e-01 | 0.6257 |
79144 | PPDPF | CRC-3-11773 | Human | Colorectum | CRC | 2.60e-12 | 6.87e-01 | 0.2564 |
79144 | PPDPF | AEH-subject1 | Human | Endometrium | AEH | 2.53e-13 | -3.54e-01 | -0.3059 |
79144 | PPDPF | AEH-subject2 | Human | Endometrium | AEH | 1.49e-15 | -4.82e-01 | -0.2525 |
79144 | PPDPF | AEH-subject3 | Human | Endometrium | AEH | 2.45e-35 | -6.59e-01 | -0.2576 |
79144 | PPDPF | AEH-subject4 | Human | Endometrium | AEH | 4.72e-46 | -9.95e-01 | -0.2657 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PPDPF | SNV | Missense_Mutation | c.131N>T | p.Pro44Leu | p.P44L | Q9H3Y8 | protein_coding | deleterious(0.02) | possibly_damaging(0.456) | TCGA-E9-A22E-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphane | SD | |
PPDPF | SNV | Missense_Mutation | novel | c.174N>A | p.Phe58Leu | p.F58L | Q9H3Y8 | protein_coding | deleterious(0.04) | benign(0.007) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
PPDPF | SNV | Missense_Mutation | novel | c.80N>G | p.Asn27Ser | p.N27S | Q9H3Y8 | protein_coding | tolerated(0.3) | benign(0.028) | TCGA-DD-AAE3-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PPDPF | SNV | Missense_Mutation | c.257N>A | p.Ser86Asn | p.S86N | Q9H3Y8 | protein_coding | tolerated(0.18) | benign(0.003) | TCGA-MI-A75H-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
PPDPF | SNV | Missense_Mutation | c.164N>T | p.Trp55Leu | p.W55L | Q9H3Y8 | protein_coding | deleterious(0) | possibly_damaging(0.856) | TCGA-64-5815-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | gemcitabine | CR | |
PPDPF | SNV | Missense_Mutation | rs759954043 | c.233N>G | p.Ser78Trp | p.S78W | Q9H3Y8 | protein_coding | deleterious(0.02) | possibly_damaging(0.753) | TCGA-NJ-A4YP-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PPDPF | SNV | Missense_Mutation | c.136N>G | p.Leu46Val | p.L46V | Q9H3Y8 | protein_coding | tolerated(0.07) | benign(0.292) | TCGA-18-3406-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
PPDPF | SNV | Missense_Mutation | novel | c.197N>T | p.Pro66Leu | p.P66L | Q9H3Y8 | protein_coding | tolerated(0.08) | probably_damaging(1) | TCGA-CR-5248-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | PD |
PPDPF | SNV | Missense_Mutation | novel | c.211N>A | p.Val71Met | p.V71M | Q9H3Y8 | protein_coding | deleterious(0.03) | possibly_damaging(0.543) | TCGA-MT-A67F-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PPDPF | SNV | Missense_Mutation | novel | c.250N>C | p.Ser84Pro | p.S84P | Q9H3Y8 | protein_coding | tolerated(0.18) | benign(0.022) | TCGA-HU-A4GT-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | copolang | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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