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Gene: POLR2F |
Gene summary for POLR2F |
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Gene information | Species | Human | Gene symbol | POLR2F | Gene ID | 5435 |
Gene name | RNA polymerase II, I and III subunit F | |
Gene Alias | HRBP14.4 | |
Cytomap | 22q13.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B0QYL9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5435 | POLR2F | P2T-E | Human | Esophagus | ESCC | 6.76e-78 | 1.23e+00 | 0.1177 |
5435 | POLR2F | P4T-E | Human | Esophagus | ESCC | 1.09e-87 | 1.85e+00 | 0.1323 |
5435 | POLR2F | P5T-E | Human | Esophagus | ESCC | 1.00e-103 | 1.60e+00 | 0.1327 |
5435 | POLR2F | P8T-E | Human | Esophagus | ESCC | 3.33e-67 | 1.16e+00 | 0.0889 |
5435 | POLR2F | P9T-E | Human | Esophagus | ESCC | 3.41e-70 | 1.36e+00 | 0.1131 |
5435 | POLR2F | P10T-E | Human | Esophagus | ESCC | 1.36e-138 | 2.07e+00 | 0.116 |
5435 | POLR2F | P11T-E | Human | Esophagus | ESCC | 3.87e-51 | 1.46e+00 | 0.1426 |
5435 | POLR2F | P12T-E | Human | Esophagus | ESCC | 1.77e-86 | 1.45e+00 | 0.1122 |
5435 | POLR2F | P15T-E | Human | Esophagus | ESCC | 4.30e-75 | 1.57e+00 | 0.1149 |
5435 | POLR2F | P16T-E | Human | Esophagus | ESCC | 8.28e-115 | 2.13e+00 | 0.1153 |
5435 | POLR2F | P17T-E | Human | Esophagus | ESCC | 2.18e-41 | 1.52e+00 | 0.1278 |
5435 | POLR2F | P19T-E | Human | Esophagus | ESCC | 1.19e-25 | 1.69e+00 | 0.1662 |
5435 | POLR2F | P20T-E | Human | Esophagus | ESCC | 2.54e-64 | 1.14e+00 | 0.1124 |
5435 | POLR2F | P21T-E | Human | Esophagus | ESCC | 2.84e-129 | 2.98e+00 | 0.1617 |
5435 | POLR2F | P22T-E | Human | Esophagus | ESCC | 8.28e-115 | 1.76e+00 | 0.1236 |
5435 | POLR2F | P23T-E | Human | Esophagus | ESCC | 1.84e-90 | 1.89e+00 | 0.108 |
5435 | POLR2F | P24T-E | Human | Esophagus | ESCC | 2.27e-90 | 1.49e+00 | 0.1287 |
5435 | POLR2F | P26T-E | Human | Esophagus | ESCC | 1.67e-124 | 2.06e+00 | 0.1276 |
5435 | POLR2F | P27T-E | Human | Esophagus | ESCC | 1.77e-86 | 1.23e+00 | 0.1055 |
5435 | POLR2F | P28T-E | Human | Esophagus | ESCC | 1.52e-107 | 1.65e+00 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501616 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0501617 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0501623 | Breast | IDC | Huntington disease | 103/867 | 306/8465 | 5.14e-30 | 4.17e-28 | 3.12e-28 | 103 |
hsa0501633 | Breast | IDC | Huntington disease | 103/867 | 306/8465 | 5.14e-30 | 4.17e-28 | 3.12e-28 | 103 |
hsa0501643 | Breast | DCIS | Huntington disease | 101/846 | 306/8465 | 1.54e-29 | 1.24e-27 | 9.13e-28 | 101 |
hsa0501653 | Breast | DCIS | Huntington disease | 101/846 | 306/8465 | 1.54e-29 | 1.24e-27 | 9.13e-28 | 101 |
hsa0501620 | Endometrium | AEH | Huntington disease | 118/1197 | 306/8465 | 3.00e-27 | 2.44e-25 | 1.78e-25 | 118 |
hsa05016110 | Endometrium | AEH | Huntington disease | 118/1197 | 306/8465 | 3.00e-27 | 2.44e-25 | 1.78e-25 | 118 |
hsa0501625 | Endometrium | EEC | Huntington disease | 120/1237 | 306/8465 | 3.86e-27 | 4.23e-25 | 3.15e-25 | 120 |
hsa0501635 | Endometrium | EEC | Huntington disease | 120/1237 | 306/8465 | 3.86e-27 | 4.23e-25 | 3.15e-25 | 120 |
hsa0501630 | Esophagus | HGIN | Huntington disease | 129/1383 | 306/8465 | 6.81e-28 | 7.41e-26 | 5.88e-26 | 129 |
hsa034205 | Esophagus | HGIN | Nucleotide excision repair | 29/1383 | 63/8465 | 2.96e-08 | 5.36e-07 | 4.26e-07 | 29 |
hsa030205 | Esophagus | HGIN | RNA polymerase | 12/1383 | 34/8465 | 5.62e-03 | 3.99e-02 | 3.17e-02 | 12 |
hsa05016113 | Esophagus | HGIN | Huntington disease | 129/1383 | 306/8465 | 6.81e-28 | 7.41e-26 | 5.88e-26 | 129 |
hsa0342012 | Esophagus | HGIN | Nucleotide excision repair | 29/1383 | 63/8465 | 2.96e-08 | 5.36e-07 | 4.26e-07 | 29 |
hsa0302012 | Esophagus | HGIN | RNA polymerase | 12/1383 | 34/8465 | 5.62e-03 | 3.99e-02 | 3.17e-02 | 12 |
hsa05016210 | Esophagus | ESCC | Huntington disease | 226/4205 | 306/8465 | 1.38e-18 | 8.72e-17 | 4.46e-17 | 226 |
hsa0342022 | Esophagus | ESCC | Nucleotide excision repair | 54/4205 | 63/8465 | 2.01e-09 | 2.17e-08 | 1.11e-08 | 54 |
hsa0302021 | Esophagus | ESCC | RNA polymerase | 28/4205 | 34/8465 | 8.19e-05 | 3.35e-04 | 1.71e-04 | 28 |
hsa046234 | Esophagus | ESCC | Cytosolic DNA-sensing pathway | 49/4205 | 75/8465 | 4.35e-03 | 1.12e-02 | 5.74e-03 | 49 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
POLR2F | SNV | Missense_Mutation | c.12C>A | p.Asn4Lys | p.N4K | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.834) | TCGA-AN-A0XT-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
POLR2F | SNV | Missense_Mutation | rs763720250 | c.206G>A | p.Arg69Gln | p.R69Q | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.999) | TCGA-AO-A03V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD | |
POLR2F | SNV | Missense_Mutation | rs759220077 | c.109N>A | p.Glu37Lys | p.E37K | protein_coding | tolerated_low_confidence(0.06) | benign(0) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
POLR2F | SNV | Missense_Mutation | rs778818192 | c.461G>A | p.Arg154Gln | p.R154Q | protein_coding | unknown(0) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
POLR2F | SNV | Missense_Mutation | rs771399849 | c.85N>A | p.Glu29Lys | p.E29K | protein_coding | deleterious_low_confidence(0.02) | benign(0) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
POLR2F | SNV | Missense_Mutation | rs760223334 | c.193N>A | p.Val65Met | p.V65M | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.994) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
POLR2F | SNV | Missense_Mutation | c.190N>T | p.Arg64Cys | p.R64C | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.999) | TCGA-DM-A288-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | ||
POLR2F | insertion | Frame_Shift_Ins | novel | c.116_117insC | p.Ser41LeufsTer? | p.S41Lfs*? | protein_coding | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |||
POLR2F | SNV | Missense_Mutation | novel | c.469G>C | p.Glu157Gln | p.E157Q | protein_coding | unknown(0) | TCGA-AX-A3G3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
POLR2F | SNV | Missense_Mutation | novel | c.266N>A | p.Pro89His | p.P89H | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.998) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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