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Gene: PHF5A |
Gene summary for PHF5A |
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Gene information | Species | Human | Gene symbol | PHF5A | Gene ID | 84844 |
Gene name | PHD finger protein 5A | |
Gene Alias | INI | |
Cytomap | 22q13.2 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | A0A024R1U2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84844 | PHF5A | P91T-E | Human | Esophagus | ESCC | 5.16e-17 | 2.39e+00 | 0.1828 |
84844 | PHF5A | P107T-E | Human | Esophagus | ESCC | 2.29e-63 | 1.83e+00 | 0.171 |
84844 | PHF5A | P126T-E | Human | Esophagus | ESCC | 3.59e-10 | 9.30e-01 | 0.1125 |
84844 | PHF5A | P127T-E | Human | Esophagus | ESCC | 2.02e-30 | 4.55e-01 | 0.0826 |
84844 | PHF5A | P128T-E | Human | Esophagus | ESCC | 6.74e-58 | 1.95e+00 | 0.1241 |
84844 | PHF5A | P130T-E | Human | Esophagus | ESCC | 8.12e-77 | 2.22e+00 | 0.1676 |
84844 | PHF5A | S43 | Human | Liver | Cirrhotic | 2.32e-04 | -1.48e-01 | -0.0187 |
84844 | PHF5A | HCC1_Meng | Human | Liver | HCC | 1.61e-61 | 8.92e-03 | 0.0246 |
84844 | PHF5A | HCC2_Meng | Human | Liver | HCC | 3.94e-12 | -6.30e-02 | 0.0107 |
84844 | PHF5A | cirrhotic2 | Human | Liver | Cirrhotic | 3.19e-05 | 6.73e-02 | 0.0201 |
84844 | PHF5A | cirrhotic3 | Human | Liver | Cirrhotic | 1.29e-03 | 5.60e-02 | 0.0215 |
84844 | PHF5A | HCC1 | Human | Liver | HCC | 2.01e-02 | 2.33e+00 | 0.5336 |
84844 | PHF5A | HCC2 | Human | Liver | HCC | 2.97e-03 | 2.33e+00 | 0.5341 |
84844 | PHF5A | Pt13.b | Human | Liver | HCC | 8.39e-10 | 5.83e-02 | 0.0251 |
84844 | PHF5A | Pt14.a | Human | Liver | HCC | 5.97e-03 | 2.05e-01 | 0.0169 |
84844 | PHF5A | S014 | Human | Liver | HCC | 2.73e-37 | 1.46e+00 | 0.2254 |
84844 | PHF5A | S015 | Human | Liver | HCC | 8.65e-30 | 1.60e+00 | 0.2375 |
84844 | PHF5A | S016 | Human | Liver | HCC | 1.86e-34 | 1.39e+00 | 0.2243 |
84844 | PHF5A | S027 | Human | Liver | HCC | 1.03e-02 | 8.40e-01 | 0.2446 |
84844 | PHF5A | S028 | Human | Liver | HCC | 2.45e-16 | 9.02e-01 | 0.2503 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:0000375111 | Esophagus | ESCC | RNA splicing, via transesterification reactions | 248/8552 | 324/18723 | 3.05e-30 | 1.49e-27 | 248 |
GO:0000377111 | Esophagus | ESCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:0000398111 | Esophagus | ESCC | mRNA splicing, via spliceosome | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
GO:00488638 | Esophagus | ESCC | stem cell differentiation | 122/8552 | 206/18723 | 5.95e-05 | 4.59e-04 | 122 |
GO:000838012 | Liver | Cirrhotic | RNA splicing | 229/4634 | 434/18723 | 9.13e-37 | 2.86e-33 | 229 |
GO:000037512 | Liver | Cirrhotic | RNA splicing, via transesterification reactions | 175/4634 | 324/18723 | 5.95e-30 | 7.47e-27 | 175 |
GO:000037712 | Liver | Cirrhotic | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 172/4634 | 320/18723 | 4.02e-29 | 3.60e-26 | 172 |
GO:000039812 | Liver | Cirrhotic | mRNA splicing, via spliceosome | 172/4634 | 320/18723 | 4.02e-29 | 3.60e-26 | 172 |
GO:004886311 | Liver | Cirrhotic | stem cell differentiation | 66/4634 | 206/18723 | 1.06e-02 | 4.68e-02 | 66 |
GO:000838022 | Liver | HCC | RNA splicing | 313/7958 | 434/18723 | 1.36e-36 | 1.73e-33 | 313 |
GO:000037522 | Liver | HCC | RNA splicing, via transesterification reactions | 228/7958 | 324/18723 | 1.47e-24 | 4.06e-22 | 228 |
GO:000037722 | Liver | HCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 224/7958 | 320/18723 | 1.16e-23 | 2.62e-21 | 224 |
GO:000039822 | Liver | HCC | mRNA splicing, via spliceosome | 224/7958 | 320/18723 | 1.16e-23 | 2.62e-21 | 224 |
GO:000838020 | Oral cavity | OSCC | RNA splicing | 308/7305 | 434/18723 | 2.43e-42 | 7.70e-39 | 308 |
GO:000037519 | Oral cavity | OSCC | RNA splicing, via transesterification reactions | 225/7305 | 324/18723 | 5.20e-29 | 2.99e-26 | 225 |
GO:000037719 | Oral cavity | OSCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 221/7305 | 320/18723 | 5.50e-28 | 2.18e-25 | 221 |
GO:000039819 | Oral cavity | OSCC | mRNA splicing, via spliceosome | 221/7305 | 320/18723 | 5.50e-28 | 2.18e-25 | 221 |
GO:00488637 | Oral cavity | OSCC | stem cell differentiation | 96/7305 | 206/18723 | 1.55e-02 | 4.99e-02 | 96 |
GO:0008380110 | Oral cavity | LP | RNA splicing | 237/4623 | 434/18723 | 1.82e-41 | 3.79e-38 | 237 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0304027 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa0304037 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa030407 | Liver | Cirrhotic | Spliceosome | 102/2530 | 217/8465 | 5.69e-08 | 9.47e-07 | 5.84e-07 | 102 |
hsa0304012 | Liver | Cirrhotic | Spliceosome | 102/2530 | 217/8465 | 5.69e-08 | 9.47e-07 | 5.84e-07 | 102 |
hsa0304022 | Liver | HCC | Spliceosome | 122/4020 | 217/8465 | 5.55e-03 | 1.60e-02 | 8.91e-03 | 122 |
hsa0304032 | Liver | HCC | Spliceosome | 122/4020 | 217/8465 | 5.55e-03 | 1.60e-02 | 8.91e-03 | 122 |
hsa0304016 | Oral cavity | OSCC | Spliceosome | 123/3704 | 217/8465 | 7.21e-05 | 2.74e-04 | 1.40e-04 | 123 |
hsa0304017 | Oral cavity | OSCC | Spliceosome | 123/3704 | 217/8465 | 7.21e-05 | 2.74e-04 | 1.40e-04 | 123 |
hsa0304026 | Oral cavity | LP | Spliceosome | 106/2418 | 217/8465 | 1.30e-10 | 2.40e-09 | 1.55e-09 | 106 |
hsa0304036 | Oral cavity | LP | Spliceosome | 106/2418 | 217/8465 | 1.30e-10 | 2.40e-09 | 1.55e-09 | 106 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PHF5A | SNV | Missense_Mutation | c.112N>T | p.Arg38Cys | p.R38C | Q7RTV0 | protein_coding | deleterious(0.05) | probably_damaging(0.967) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PHF5A | insertion | Frame_Shift_Ins | novel | c.1_2insAATTTGTTCT | p.Met1? | p.M1? | Q7RTV0 | protein_coding | TCGA-D1-A0ZR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PHF5A | SNV | Missense_Mutation | c.17N>T | p.Pro6Leu | p.P6L | Q7RTV0 | protein_coding | tolerated(0.39) | probably_damaging(0.969) | TCGA-51-6867-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PHF5A | SNV | Missense_Mutation | c.169C>T | p.Arg57Cys | p.R57C | Q7RTV0 | protein_coding | deleterious(0) | benign(0.125) | TCGA-63-A5MM-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
PHF5A | SNV | Missense_Mutation | novel | c.130N>T | p.Arg44Cys | p.R44C | Q7RTV0 | protein_coding | deleterious(0.04) | benign(0.094) | TCGA-BA-5153-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unspecific | Xeloda | PD |
PHF5A | insertion | Frame_Shift_Ins | novel | c.312_313insA | p.Tyr105IlefsTer64 | p.Y105Ifs*64 | Q7RTV0 | protein_coding | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
PHF5A | SNV | Missense_Mutation | c.113G>A | p.Arg38His | p.R38H | Q7RTV0 | protein_coding | tolerated(0.06) | benign(0.051) | TCGA-KK-A59V-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD | |
PHF5A | SNV | Missense_Mutation | novel | c.165N>T | p.Gln55His | p.Q55H | Q7RTV0 | protein_coding | deleterious(0.04) | benign(0.049) | TCGA-VQ-AA6D-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Chemotherapy | fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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