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Gene: PCSK5 |
Gene summary for PCSK5 |
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Gene information | Species | Human | Gene symbol | PCSK5 | Gene ID | 5125 |
Gene name | proprotein convertase subtilisin/kexin type 5 | |
Gene Alias | PC5 | |
Cytomap | 9q21.13 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q92824 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5125 | PCSK5 | P26T-E | Human | Esophagus | ESCC | 7.47e-08 | 1.06e-01 | 0.1276 |
5125 | PCSK5 | P28T-E | Human | Esophagus | ESCC | 5.27e-04 | 5.15e-02 | 0.1149 |
5125 | PCSK5 | P30T-E | Human | Esophagus | ESCC | 1.45e-10 | 4.74e-01 | 0.137 |
5125 | PCSK5 | P31T-E | Human | Esophagus | ESCC | 1.48e-73 | 1.40e+00 | 0.1251 |
5125 | PCSK5 | P32T-E | Human | Esophagus | ESCC | 6.19e-08 | 2.27e-01 | 0.1666 |
5125 | PCSK5 | P39T-E | Human | Esophagus | ESCC | 1.73e-08 | 3.26e-01 | 0.0894 |
5125 | PCSK5 | P44T-E | Human | Esophagus | ESCC | 5.84e-05 | 1.46e-01 | 0.1096 |
5125 | PCSK5 | P47T-E | Human | Esophagus | ESCC | 1.25e-06 | 3.97e-02 | 0.1067 |
5125 | PCSK5 | P48T-E | Human | Esophagus | ESCC | 5.42e-04 | 9.60e-02 | 0.0959 |
5125 | PCSK5 | P49T-E | Human | Esophagus | ESCC | 3.89e-14 | 1.18e+00 | 0.1768 |
5125 | PCSK5 | P65T-E | Human | Esophagus | ESCC | 2.14e-03 | 3.74e-02 | 0.0978 |
5125 | PCSK5 | P74T-E | Human | Esophagus | ESCC | 2.92e-05 | 2.69e-01 | 0.1479 |
5125 | PCSK5 | P75T-E | Human | Esophagus | ESCC | 1.18e-05 | 1.78e-01 | 0.1125 |
5125 | PCSK5 | P76T-E | Human | Esophagus | ESCC | 9.40e-09 | 4.37e-02 | 0.1207 |
5125 | PCSK5 | P83T-E | Human | Esophagus | ESCC | 1.31e-11 | 4.22e-01 | 0.1738 |
5125 | PCSK5 | P107T-E | Human | Esophagus | ESCC | 1.25e-13 | 4.26e-01 | 0.171 |
5125 | PCSK5 | NAFLD1 | Human | Liver | NAFLD | 4.12e-02 | 3.95e-01 | -0.04 |
5125 | PCSK5 | HCC1_Meng | Human | Liver | HCC | 2.99e-11 | 9.32e-03 | 0.0246 |
5125 | PCSK5 | HCC2_Meng | Human | Liver | HCC | 1.17e-03 | 3.99e-02 | 0.0107 |
5125 | PCSK5 | HCC1 | Human | Liver | HCC | 2.69e-02 | 2.11e+00 | 0.5336 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016032 | Colorectum | AD | viral process | 168/3918 | 415/18723 | 4.67e-20 | 3.66e-17 | 168 |
GO:0019058 | Colorectum | AD | viral life cycle | 119/3918 | 317/18723 | 6.18e-12 | 8.23e-10 | 119 |
GO:0006465 | Colorectum | AD | signal peptide processing | 10/3918 | 14/18723 | 6.90e-05 | 1.11e-03 | 10 |
GO:0009306 | Colorectum | AD | protein secretion | 105/3918 | 359/18723 | 1.05e-04 | 1.57e-03 | 105 |
GO:0035592 | Colorectum | AD | establishment of protein localization to extracellular region | 105/3918 | 360/18723 | 1.18e-04 | 1.73e-03 | 105 |
GO:0071692 | Colorectum | AD | protein localization to extracellular region | 106/3918 | 368/18723 | 1.86e-04 | 2.49e-03 | 106 |
GO:0051604 | Colorectum | AD | protein maturation | 85/3918 | 294/18723 | 6.73e-04 | 6.91e-03 | 85 |
GO:0048736 | Colorectum | AD | appendage development | 51/3918 | 172/18723 | 4.20e-03 | 2.89e-02 | 51 |
GO:0060173 | Colorectum | AD | limb development | 51/3918 | 172/18723 | 4.20e-03 | 2.89e-02 | 51 |
GO:0048568 | Colorectum | AD | embryonic organ development | 112/3918 | 427/18723 | 4.60e-03 | 3.14e-02 | 112 |
GO:0003014 | Colorectum | AD | renal system process | 35/3918 | 110/18723 | 4.85e-03 | 3.27e-02 | 35 |
GO:0016485 | Colorectum | AD | protein processing | 63/3918 | 225/18723 | 6.77e-03 | 4.19e-02 | 63 |
GO:00160321 | Colorectum | SER | viral process | 118/2897 | 415/18723 | 8.36e-12 | 1.65e-09 | 118 |
GO:00190581 | Colorectum | SER | viral life cycle | 87/2897 | 317/18723 | 2.82e-08 | 1.94e-06 | 87 |
GO:00516041 | Colorectum | SER | protein maturation | 73/2897 | 294/18723 | 1.82e-05 | 5.38e-04 | 73 |
GO:00164851 | Colorectum | SER | protein processing | 55/2897 | 225/18723 | 2.84e-04 | 4.67e-03 | 55 |
GO:00093061 | Colorectum | SER | protein secretion | 79/2897 | 359/18723 | 5.99e-04 | 8.19e-03 | 79 |
GO:00355921 | Colorectum | SER | establishment of protein localization to extracellular region | 79/2897 | 360/18723 | 6.54e-04 | 8.77e-03 | 79 |
GO:00716921 | Colorectum | SER | protein localization to extracellular region | 80/2897 | 368/18723 | 8.13e-04 | 1.01e-02 | 80 |
GO:00030141 | Colorectum | SER | renal system process | 30/2897 | 110/18723 | 1.05e-03 | 1.22e-02 | 30 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PCSK5 | SNV | Missense_Mutation | novel | c.5425N>C | p.Glu1809Gln | p.E1809Q | Q92824 | protein_coding | tolerated(0.06) | benign(0.198) | TCGA-A2-A0CR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
PCSK5 | SNV | Missense_Mutation | rs752780597 | c.4225A>G | p.Thr1409Ala | p.T1409A | Q92824 | protein_coding | tolerated(0.29) | benign(0.162) | TCGA-A8-A07B-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PCSK5 | SNV | Missense_Mutation | rs763309564 | c.1391N>A | p.Arg464Gln | p.R464Q | Q92824 | protein_coding | tolerated(1) | benign(0) | TCGA-A8-A07O-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | CR | |
PCSK5 | SNV | Missense_Mutation | novel | c.2485N>A | p.Glu829Lys | p.E829K | Q92824 | protein_coding | deleterious(0.03) | benign(0.039) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PCSK5 | SNV | Missense_Mutation | c.2609G>C | p.Gly870Ala | p.G870A | Q92824 | protein_coding | deleterious(0.01) | possibly_damaging(0.643) | TCGA-BH-A0DZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | |
PCSK5 | SNV | Missense_Mutation | c.471N>C | p.Lys157Asn | p.K157N | Q92824 | protein_coding | deleterious(0) | benign(0.313) | TCGA-BH-A0W7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
PCSK5 | SNV | Missense_Mutation | c.1817N>G | p.Thr606Ser | p.T606S | Q92824 | protein_coding | tolerated(0.18) | benign(0.029) | TCGA-BH-A1F2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
PCSK5 | SNV | Missense_Mutation | rs373649072 | c.2213N>A | p.Arg738Gln | p.R738Q | Q92824 | protein_coding | deleterious(0.02) | probably_damaging(0.915) | TCGA-E2-A1IE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | PD |
PCSK5 | SNV | Missense_Mutation | c.2276G>C | p.Gly759Ala | p.G759A | Q92824 | protein_coding | deleterious(0) | probably_damaging(0.943) | TCGA-E2-A1LH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
PCSK5 | insertion | Frame_Shift_Ins | novel | c.3960_3961insCAATTCTCCTGTCTCAGCCTCCCGAGTAGCT | p.Gly1321GlnfsTer26 | p.G1321Qfs*26 | Q92824 | protein_coding | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5125 | PCSK5 | PROTEASE, DRUGGABLE GENOME, ENZYME | inhibitor | 178103178 | ||
5125 | PCSK5 | PROTEASE, DRUGGABLE GENOME, ENZYME | inhibitor | 252166868 |
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