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Gene: PCSK1N |
Gene summary for PCSK1N |
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Gene information | Species | Human | Gene symbol | PCSK1N | Gene ID | 27344 |
Gene name | proprotein convertase subtilisin/kexin type 1 inhibitor | |
Gene Alias | BigLEN | |
Cytomap | Xp11.23 | |
Gene Type | protein-coding | GO ID | GO:0002021 | UniProtAcc | Q9UHG2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27344 | PCSK1N | C30 | Human | Oral cavity | OSCC | 2.81e-02 | 4.82e-01 | 0.3055 |
27344 | PCSK1N | C38 | Human | Oral cavity | OSCC | 7.26e-13 | 1.35e+00 | 0.172 |
27344 | PCSK1N | C08 | Human | Oral cavity | OSCC | 4.00e-10 | 3.31e-01 | 0.1919 |
27344 | PCSK1N | C09 | Human | Oral cavity | OSCC | 7.04e-18 | 1.26e+00 | 0.1431 |
27344 | PCSK1N | LN38 | Human | Oral cavity | OSCC | 1.03e-05 | 1.84e+00 | 0.168 |
27344 | PCSK1N | SYSMH3 | Human | Oral cavity | OSCC | 6.18e-19 | 7.13e-01 | 0.2442 |
27344 | PCSK1N | SYSMH5 | Human | Oral cavity | OSCC | 6.68e-03 | 8.06e-02 | 0.0647 |
27344 | PCSK1N | HTA12-15-2 | Human | Pancreas | PDAC | 3.58e-39 | 1.97e+00 | 0.2315 |
27344 | PCSK1N | HTA12-18-3 | Human | Pancreas | PDAC | 3.37e-02 | 7.12e-01 | 0.0716 |
27344 | PCSK1N | HTA12-23-1 | Human | Pancreas | PDAC | 6.92e-13 | 1.32e+00 | 0.3405 |
27344 | PCSK1N | HTA12-25-1 | Human | Pancreas | PDAC | 1.46e-16 | 1.22e+00 | 0.313 |
27344 | PCSK1N | HTA12-26-1 | Human | Pancreas | PDAC | 8.16e-39 | 1.47e+00 | 0.3728 |
27344 | PCSK1N | HTA12-29-1 | Human | Pancreas | PDAC | 2.03e-35 | 9.12e-01 | 0.3722 |
27344 | PCSK1N | HTA12-9-1 | Human | Pancreas | PDAC | 2.94e-06 | 8.02e-01 | 0.1532 |
27344 | PCSK1N | HTA12-9-2 | Human | Pancreas | PDAC | 8.64e-10 | 8.77e-01 | 0.0835 |
27344 | PCSK1N | HTA12-9-3 | Human | Pancreas | PDAC | 1.14e-08 | 1.14e+00 | 0.2045 |
27344 | PCSK1N | 4347-EC | Human | Pancreas | PanIN | 3.95e-04 | 4.54e-01 | 0.0572 |
27344 | PCSK1N | GSM5252126_BPH283PrGF_Via | Human | Prostate | BPH | 4.81e-04 | 1.74e-01 | -0.1771 |
27344 | PCSK1N | GSM5252128_BPH327PrGF_Via | Human | Prostate | BPH | 3.67e-42 | 7.75e-01 | -0.1688 |
27344 | PCSK1N | GSM5252129_BPH327PrSF_Via | Human | Prostate | BPH | 5.17e-05 | 6.06e-01 | -0.1697 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005254714 | Breast | IDC | regulation of peptidase activity | 96/1434 | 461/18723 | 7.58e-20 | 6.15e-17 | 96 |
GO:005254814 | Breast | IDC | regulation of endopeptidase activity | 88/1434 | 432/18723 | 1.20e-17 | 4.85e-15 | 88 |
GO:004586114 | Breast | IDC | negative regulation of proteolysis | 70/1434 | 351/18723 | 8.21e-14 | 2.22e-11 | 70 |
GO:005134613 | Breast | IDC | negative regulation of hydrolase activity | 71/1434 | 379/18723 | 1.33e-12 | 2.90e-10 | 71 |
GO:001046613 | Breast | IDC | negative regulation of peptidase activity | 56/1434 | 262/18723 | 1.39e-12 | 2.92e-10 | 56 |
GO:001095112 | Breast | IDC | negative regulation of endopeptidase activity | 52/1434 | 252/18723 | 3.53e-11 | 5.57e-09 | 52 |
GO:000926612 | Breast | IDC | response to temperature stimulus | 34/1434 | 178/18723 | 5.88e-07 | 2.83e-05 | 34 |
GO:003166714 | Breast | IDC | response to nutrient levels | 62/1434 | 474/18723 | 2.33e-05 | 5.57e-04 | 62 |
GO:000940912 | Breast | IDC | response to cold | 13/1434 | 49/18723 | 5.70e-05 | 1.20e-03 | 13 |
GO:005160413 | Breast | IDC | protein maturation | 35/1434 | 294/18723 | 6.18e-03 | 4.40e-02 | 35 |
GO:005254710 | Cervix | CC | regulation of peptidase activity | 112/2311 | 461/18723 | 6.70e-13 | 3.08e-10 | 112 |
GO:005254810 | Cervix | CC | regulation of endopeptidase activity | 103/2311 | 432/18723 | 1.89e-11 | 5.14e-09 | 103 |
GO:004586110 | Cervix | CC | negative regulation of proteolysis | 80/2311 | 351/18723 | 2.88e-08 | 1.98e-06 | 80 |
GO:00513469 | Cervix | CC | negative regulation of hydrolase activity | 81/2311 | 379/18723 | 4.27e-07 | 1.67e-05 | 81 |
GO:00104669 | Cervix | CC | negative regulation of peptidase activity | 60/2311 | 262/18723 | 1.27e-06 | 4.34e-05 | 60 |
GO:003166710 | Cervix | CC | response to nutrient levels | 92/2311 | 474/18723 | 5.80e-06 | 1.42e-04 | 92 |
GO:001095110 | Cervix | CC | negative regulation of endopeptidase activity | 56/2311 | 252/18723 | 7.43e-06 | 1.74e-04 | 56 |
GO:00516048 | Cervix | CC | protein maturation | 56/2311 | 294/18723 | 5.90e-04 | 5.59e-03 | 56 |
GO:00092668 | Cervix | CC | response to temperature stimulus | 37/2311 | 178/18723 | 9.45e-04 | 7.95e-03 | 37 |
GO:00094098 | Cervix | CC | response to cold | 13/2311 | 49/18723 | 5.34e-03 | 3.10e-02 | 13 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PCSK1N | SNV | Missense_Mutation | c.643C>T | p.Pro215Ser | p.P215S | Q9UHG2 | protein_coding | deleterious_low_confidence(0.02) | benign(0.099) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
PCSK1N | SNV | Missense_Mutation | novel | c.767N>A | p.Arg256His | p.R256H | Q9UHG2 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.958) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
PCSK1N | SNV | Missense_Mutation | novel | c.767N>A | p.Arg256His | p.R256H | Q9UHG2 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.958) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
PCSK1N | SNV | Missense_Mutation | novel | c.152N>T | p.Ala51Val | p.A51V | Q9UHG2 | protein_coding | tolerated_low_confidence(0.12) | benign(0.003) | TCGA-55-1595-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PCSK1N | SNV | Missense_Mutation | novel | c.767G>A | p.Arg256His | p.R256H | Q9UHG2 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.958) | TCGA-HU-A4G8-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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