![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: PAXX |
Gene summary for PAXX |
![]() |
Gene information | Species | Human | Gene symbol | PAXX | Gene ID | 286257 |
Gene name | PAXX non-homologous end joining factor | |
Gene Alias | C9orf142 | |
Cytomap | 9q34.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9BUH6 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
286257 | PAXX | PTC04 | Human | Thyroid | PTC | 7.27e-33 | 5.83e-01 | 0.1927 |
286257 | PAXX | PTC05 | Human | Thyroid | PTC | 3.51e-24 | 9.00e-01 | 0.2065 |
286257 | PAXX | PTC06 | Human | Thyroid | PTC | 1.22e-39 | 8.06e-01 | 0.2057 |
286257 | PAXX | PTC07 | Human | Thyroid | PTC | 6.52e-69 | 1.08e+00 | 0.2044 |
286257 | PAXX | ATC09 | Human | Thyroid | ATC | 1.12e-05 | 2.42e-01 | 0.2871 |
286257 | PAXX | ATC11 | Human | Thyroid | ATC | 2.49e-06 | 4.03e-01 | 0.3386 |
286257 | PAXX | ATC12 | Human | Thyroid | ATC | 1.13e-11 | 2.59e-01 | 0.34 |
286257 | PAXX | ATC13 | Human | Thyroid | ATC | 4.31e-39 | 6.99e-01 | 0.34 |
286257 | PAXX | ATC1 | Human | Thyroid | ATC | 2.78e-04 | 2.35e-01 | 0.2878 |
286257 | PAXX | ATC3 | Human | Thyroid | ATC | 3.69e-12 | 4.95e-01 | 0.338 |
286257 | PAXX | ATC4 | Human | Thyroid | ATC | 2.55e-14 | 3.21e-01 | 0.34 |
286257 | PAXX | ATC5 | Human | Thyroid | ATC | 2.00e-43 | 7.80e-01 | 0.34 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00063024 | Esophagus | ESCC | double-strand break repair | 152/8552 | 251/18723 | 1.33e-06 | 1.62e-05 | 152 |
GO:0006303 | Esophagus | ESCC | double-strand break repair via nonhomologous end joining | 43/8552 | 66/18723 | 1.10e-03 | 5.53e-03 | 43 |
GO:00063021 | Liver | HCC | double-strand break repair | 131/7958 | 251/18723 | 1.17e-03 | 6.54e-03 | 131 |
GO:00063026 | Thyroid | PTC | double-strand break repair | 103/5968 | 251/18723 | 1.30e-03 | 7.40e-03 | 103 |
GO:00063032 | Thyroid | PTC | double-strand break repair via nonhomologous end joining | 32/5968 | 66/18723 | 3.55e-03 | 1.71e-02 | 32 |
GO:000630212 | Thyroid | ATC | double-strand break repair | 110/6293 | 251/18723 | 4.48e-04 | 2.65e-03 | 110 |
GO:00063031 | Thyroid | ATC | double-strand break repair via nonhomologous end joining | 33/6293 | 66/18723 | 4.27e-03 | 1.80e-02 | 33 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |