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Gene: NUDT22 |
Gene summary for NUDT22 |
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Gene information | Species | Human | Gene symbol | NUDT22 | Gene ID | 84304 |
Gene name | nudix hydrolase 22 | |
Gene Alias | NUDT22 | |
Cytomap | 11q13.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9BRQ3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84304 | NUDT22 | P94T-E | Human | Esophagus | ESCC | 4.00e-02 | 9.30e-01 | 0.0879 |
84304 | NUDT22 | P104T-E | Human | Esophagus | ESCC | 1.24e-06 | 4.93e-01 | 0.0931 |
84304 | NUDT22 | P107T-E | Human | Esophagus | ESCC | 1.47e-50 | 9.96e-01 | 0.171 |
84304 | NUDT22 | P126T-E | Human | Esophagus | ESCC | 5.03e-05 | 8.32e-01 | 0.1125 |
84304 | NUDT22 | P127T-E | Human | Esophagus | ESCC | 4.84e-27 | 4.76e-01 | 0.0826 |
84304 | NUDT22 | P128T-E | Human | Esophagus | ESCC | 1.43e-51 | 1.25e+00 | 0.1241 |
84304 | NUDT22 | P130T-E | Human | Esophagus | ESCC | 2.25e-53 | 1.05e+00 | 0.1676 |
84304 | NUDT22 | HCC1_Meng | Human | Liver | HCC | 8.98e-72 | 2.89e-01 | 0.0246 |
84304 | NUDT22 | HCC2_Meng | Human | Liver | HCC | 7.75e-30 | 1.82e-01 | 0.0107 |
84304 | NUDT22 | cirrhotic1 | Human | Liver | Cirrhotic | 2.82e-04 | 1.62e-01 | 0.0202 |
84304 | NUDT22 | cirrhotic2 | Human | Liver | Cirrhotic | 5.99e-04 | 1.44e-01 | 0.0201 |
84304 | NUDT22 | cirrhotic3 | Human | Liver | Cirrhotic | 8.77e-06 | 1.77e-01 | 0.0215 |
84304 | NUDT22 | HCC2 | Human | Liver | HCC | 7.47e-06 | 2.11e+00 | 0.5341 |
84304 | NUDT22 | Pt13.b | Human | Liver | HCC | 4.50e-07 | 1.20e-01 | 0.0251 |
84304 | NUDT22 | Pt14.a | Human | Liver | HCC | 2.31e-04 | 3.09e-01 | 0.0169 |
84304 | NUDT22 | S014 | Human | Liver | HCC | 2.41e-16 | 7.24e-01 | 0.2254 |
84304 | NUDT22 | S015 | Human | Liver | HCC | 6.12e-12 | 8.08e-01 | 0.2375 |
84304 | NUDT22 | S016 | Human | Liver | HCC | 6.24e-13 | 7.35e-01 | 0.2243 |
84304 | NUDT22 | S028 | Human | Liver | HCC | 6.11e-05 | 4.89e-01 | 0.2503 |
84304 | NUDT22 | S029 | Human | Liver | HCC | 2.83e-08 | 5.53e-01 | 0.2581 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NUDT22 | SNV | Missense_Mutation | novel | c.763G>A | p.Glu255Lys | p.E255K | Q9BRQ3 | protein_coding | tolerated(0.47) | benign(0.021) | TCGA-VS-A9UL-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
NUDT22 | SNV | Missense_Mutation | c.316N>T | p.Gly106Cys | p.G106C | Q9BRQ3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NUDT22 | SNV | Missense_Mutation | novel | c.152N>T | p.Ala51Val | p.A51V | Q9BRQ3 | protein_coding | tolerated(0.15) | benign(0.076) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NUDT22 | SNV | Missense_Mutation | novel | c.187N>A | p.Leu63Met | p.L63M | Q9BRQ3 | protein_coding | deleterious(0.04) | probably_damaging(0.928) | TCGA-F4-6703-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NUDT22 | SNV | Missense_Mutation | rs763178803 | c.175N>T | p.Pro59Ser | p.P59S | Q9BRQ3 | protein_coding | tolerated(0.66) | benign(0.005) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NUDT22 | SNV | Missense_Mutation | rs764713316 | c.730N>A | p.Glu244Lys | p.E244K | Q9BRQ3 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A5-A2K7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD |
NUDT22 | SNV | Missense_Mutation | novel | c.98N>A | p.Pro33Gln | p.P33Q | Q9BRQ3 | protein_coding | tolerated(0.22) | benign(0.281) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NUDT22 | SNV | Missense_Mutation | c.775G>A | p.Val259Met | p.V259M | Q9BRQ3 | protein_coding | tolerated(0.27) | benign(0.095) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NUDT22 | SNV | Missense_Mutation | c.602N>C | p.Leu201Pro | p.L201P | Q9BRQ3 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-B5-A11U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
NUDT22 | SNV | Missense_Mutation | novel | c.732N>T | p.Glu244Asp | p.E244D | Q9BRQ3 | protein_coding | deleterious(0) | possibly_damaging(0.755) | TCGA-B5-A11Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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