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Gene: NUDT14 |
Gene summary for NUDT14 |
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Gene information | Species | Human | Gene symbol | NUDT14 | Gene ID | 256281 |
Gene name | nudix hydrolase 14 | |
Gene Alias | UGPP | |
Cytomap | 14q32.33 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B3KXY7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
256281 | NUDT14 | P127T-E | Human | Esophagus | ESCC | 7.39e-37 | 7.21e-01 | 0.0826 |
256281 | NUDT14 | P128T-E | Human | Esophagus | ESCC | 2.76e-51 | 1.56e+00 | 0.1241 |
256281 | NUDT14 | P130T-E | Human | Esophagus | ESCC | 2.16e-73 | 1.35e+00 | 0.1676 |
256281 | NUDT14 | S43 | Human | Liver | Cirrhotic | 7.22e-06 | -2.24e-01 | -0.0187 |
256281 | NUDT14 | HCC1_Meng | Human | Liver | HCC | 4.56e-88 | 3.13e-01 | 0.0246 |
256281 | NUDT14 | HCC2_Meng | Human | Liver | HCC | 1.18e-15 | -7.68e-02 | 0.0107 |
256281 | NUDT14 | cirrhotic1 | Human | Liver | Cirrhotic | 2.36e-06 | 6.68e-02 | 0.0202 |
256281 | NUDT14 | cirrhotic2 | Human | Liver | Cirrhotic | 1.14e-13 | 1.70e-01 | 0.0201 |
256281 | NUDT14 | cirrhotic3 | Human | Liver | Cirrhotic | 3.85e-06 | 6.63e-02 | 0.0215 |
256281 | NUDT14 | HCC2 | Human | Liver | HCC | 4.24e-06 | 3.14e+00 | 0.5341 |
256281 | NUDT14 | HCC5 | Human | Liver | HCC | 3.34e-11 | -1.31e-01 | 0.4932 |
256281 | NUDT14 | Pt13.b | Human | Liver | HCC | 1.11e-05 | -4.01e-02 | 0.0251 |
256281 | NUDT14 | S014 | Human | Liver | HCC | 7.00e-10 | 6.11e-01 | 0.2254 |
256281 | NUDT14 | S015 | Human | Liver | HCC | 2.02e-10 | 9.22e-01 | 0.2375 |
256281 | NUDT14 | S016 | Human | Liver | HCC | 9.96e-12 | 6.66e-01 | 0.2243 |
256281 | NUDT14 | S028 | Human | Liver | HCC | 3.10e-08 | 5.54e-01 | 0.2503 |
256281 | NUDT14 | S029 | Human | Liver | HCC | 4.30e-12 | 8.66e-01 | 0.2581 |
256281 | NUDT14 | C04 | Human | Oral cavity | OSCC | 5.30e-30 | 1.47e+00 | 0.2633 |
256281 | NUDT14 | C21 | Human | Oral cavity | OSCC | 7.86e-38 | 1.24e+00 | 0.2678 |
256281 | NUDT14 | C30 | Human | Oral cavity | OSCC | 6.21e-53 | 2.43e+00 | 0.3055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000675320 | Esophagus | HGIN | nucleoside phosphate metabolic process | 93/2587 | 497/18723 | 1.25e-03 | 1.49e-02 | 93 |
GO:001969320 | Esophagus | HGIN | ribose phosphate metabolic process | 75/2587 | 396/18723 | 2.53e-03 | 2.51e-02 | 75 |
GO:00064876 | Esophagus | HGIN | protein N-linked glycosylation | 17/2587 | 65/18723 | 6.04e-03 | 4.87e-02 | 17 |
GO:0006753110 | Esophagus | ESCC | nucleoside phosphate metabolic process | 288/8552 | 497/18723 | 1.80e-08 | 3.50e-07 | 288 |
GO:0019693111 | Esophagus | ESCC | ribose phosphate metabolic process | 234/8552 | 396/18723 | 4.24e-08 | 7.76e-07 | 234 |
GO:000648714 | Esophagus | ESCC | protein N-linked glycosylation | 51/8552 | 65/18723 | 6.41e-08 | 1.13e-06 | 51 |
GO:00091002 | Esophagus | ESCC | glycoprotein metabolic process | 226/8552 | 387/18723 | 2.64e-07 | 3.94e-06 | 226 |
GO:00181969 | Esophagus | ESCC | peptidyl-asparagine modification | 22/8552 | 24/18723 | 2.82e-06 | 3.21e-05 | 22 |
GO:00700854 | Esophagus | ESCC | glycosylation | 144/8552 | 240/18723 | 5.12e-06 | 5.38e-05 | 144 |
GO:00182799 | Esophagus | ESCC | protein N-linked glycosylation via asparagine | 21/8552 | 23/18723 | 5.69e-06 | 5.90e-05 | 21 |
GO:00064865 | Esophagus | ESCC | protein glycosylation | 135/8552 | 226/18723 | 1.36e-05 | 1.24e-04 | 135 |
GO:00434135 | Esophagus | ESCC | macromolecule glycosylation | 135/8552 | 226/18723 | 1.36e-05 | 1.24e-04 | 135 |
GO:00091012 | Esophagus | ESCC | glycoprotein biosynthetic process | 181/8552 | 317/18723 | 2.54e-05 | 2.15e-04 | 181 |
GO:000675312 | Liver | Cirrhotic | nucleoside phosphate metabolic process | 190/4634 | 497/18723 | 1.10e-11 | 6.96e-10 | 190 |
GO:001969312 | Liver | Cirrhotic | ribose phosphate metabolic process | 156/4634 | 396/18723 | 5.83e-11 | 3.23e-09 | 156 |
GO:00182795 | Liver | Cirrhotic | protein N-linked glycosylation via asparagine | 16/4634 | 23/18723 | 7.54e-06 | 1.15e-04 | 16 |
GO:00181965 | Liver | Cirrhotic | peptidyl-asparagine modification | 16/4634 | 24/18723 | 1.74e-05 | 2.37e-04 | 16 |
GO:00064873 | Liver | Cirrhotic | protein N-linked glycosylation | 30/4634 | 65/18723 | 1.40e-04 | 1.36e-03 | 30 |
GO:000675322 | Liver | HCC | nucleoside phosphate metabolic process | 304/7958 | 497/18723 | 1.78e-17 | 1.85e-15 | 304 |
GO:001969322 | Liver | HCC | ribose phosphate metabolic process | 248/7958 | 396/18723 | 3.15e-16 | 2.70e-14 | 248 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NUDT14 | SNV | Missense_Mutation | rs776403747 | c.214N>T | p.Arg72Cys | p.R72C | O95848 | protein_coding | deleterious(0) | benign(0.012) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
NUDT14 | SNV | Missense_Mutation | rs141847132 | c.283N>A | p.Gly95Ser | p.G95S | O95848 | protein_coding | deleterious(0.02) | benign(0.392) | TCGA-DS-A0VN-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
NUDT14 | SNV | Missense_Mutation | rs754096722 | c.418N>A | p.Ala140Thr | p.A140T | O95848 | protein_coding | tolerated(1) | benign(0.003) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
NUDT14 | SNV | Missense_Mutation | rs368844988 | c.610N>A | p.Val204Ile | p.V204I | O95848 | protein_coding | tolerated(0.05) | probably_damaging(0.995) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
NUDT14 | SNV | Missense_Mutation | c.578N>T | p.Ala193Val | p.A193V | O95848 | protein_coding | tolerated(0.3) | benign(0.019) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NUDT14 | SNV | Missense_Mutation | c.199N>A | p.Ala67Thr | p.A67T | O95848 | protein_coding | tolerated(0.38) | possibly_damaging(0.657) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NUDT14 | SNV | Missense_Mutation | rs776403747 | c.214N>T | p.Arg72Cys | p.R72C | O95848 | protein_coding | deleterious(0) | benign(0.012) | TCGA-AP-A05O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
NUDT14 | SNV | Missense_Mutation | rs767168556 | c.607N>A | p.Gly203Ser | p.G203S | O95848 | protein_coding | tolerated(0.12) | possibly_damaging(0.45) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
NUDT14 | SNV | Missense_Mutation | rs776403747 | c.214N>T | p.Arg72Cys | p.R72C | O95848 | protein_coding | deleterious(0) | benign(0.012) | TCGA-AX-A06H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
NUDT14 | SNV | Missense_Mutation | rs141847132 | c.283N>A | p.Gly95Ser | p.G95S | O95848 | protein_coding | deleterious(0.02) | benign(0.392) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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