![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: NT5C3A |
Gene summary for NT5C3A |
![]() |
Gene information | Species | Human | Gene symbol | NT5C3A | Gene ID | 51251 |
Gene name | 5'-nucleotidase, cytosolic IIIA | |
Gene Alias | NT5C3 | |
Cytomap | 7p14.3 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | A0A024RA81 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51251 | NT5C3A | P91T-E | Human | Esophagus | ESCC | 1.38e-08 | 1.14e+00 | 0.1828 |
51251 | NT5C3A | P107T-E | Human | Esophagus | ESCC | 7.53e-40 | 1.21e+00 | 0.171 |
51251 | NT5C3A | P127T-E | Human | Esophagus | ESCC | 2.31e-13 | 1.95e-01 | 0.0826 |
51251 | NT5C3A | P128T-E | Human | Esophagus | ESCC | 3.02e-33 | 1.15e+00 | 0.1241 |
51251 | NT5C3A | P130T-E | Human | Esophagus | ESCC | 8.08e-53 | 1.28e+00 | 0.1676 |
51251 | NT5C3A | S43 | Human | Liver | Cirrhotic | 1.88e-04 | -1.07e-01 | -0.0187 |
51251 | NT5C3A | HCC1_Meng | Human | Liver | HCC | 4.66e-62 | 1.87e-01 | 0.0246 |
51251 | NT5C3A | HCC2_Meng | Human | Liver | HCC | 3.69e-32 | 2.18e-01 | 0.0107 |
51251 | NT5C3A | Pt13.b | Human | Liver | HCC | 3.55e-02 | -2.89e-02 | 0.0251 |
51251 | NT5C3A | S014 | Human | Liver | HCC | 5.94e-10 | 6.18e-01 | 0.2254 |
51251 | NT5C3A | S015 | Human | Liver | HCC | 8.64e-12 | 6.51e-01 | 0.2375 |
51251 | NT5C3A | S016 | Human | Liver | HCC | 1.12e-13 | 6.55e-01 | 0.2243 |
51251 | NT5C3A | S027 | Human | Liver | HCC | 4.95e-07 | 1.14e+00 | 0.2446 |
51251 | NT5C3A | S028 | Human | Liver | HCC | 8.98e-14 | 9.59e-01 | 0.2503 |
51251 | NT5C3A | S029 | Human | Liver | HCC | 1.28e-11 | 1.17e+00 | 0.2581 |
51251 | NT5C3A | C04 | Human | Oral cavity | OSCC | 2.35e-32 | 1.34e+00 | 0.2633 |
51251 | NT5C3A | C21 | Human | Oral cavity | OSCC | 5.37e-43 | 1.33e+00 | 0.2678 |
51251 | NT5C3A | C30 | Human | Oral cavity | OSCC | 3.22e-54 | 2.68e+00 | 0.3055 |
51251 | NT5C3A | C38 | Human | Oral cavity | OSCC | 3.08e-08 | 9.60e-01 | 0.172 |
51251 | NT5C3A | C43 | Human | Oral cavity | OSCC | 5.43e-28 | 6.75e-01 | 0.1704 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000961518 | Esophagus | ESCC | response to virus | 238/8552 | 367/18723 | 6.65e-14 | 3.32e-12 | 238 |
GO:00516075 | Esophagus | ESCC | defense response to virus | 171/8552 | 265/18723 | 3.91e-10 | 1.05e-08 | 171 |
GO:01405465 | Esophagus | ESCC | defense response to symbiont | 171/8552 | 265/18723 | 3.91e-10 | 1.05e-08 | 171 |
GO:001631110 | Esophagus | ESCC | dephosphorylation | 251/8552 | 417/18723 | 1.26e-09 | 2.99e-08 | 251 |
GO:0006753110 | Esophagus | ESCC | nucleoside phosphate metabolic process | 288/8552 | 497/18723 | 1.80e-08 | 3.50e-07 | 288 |
GO:0009117111 | Esophagus | ESCC | nucleotide metabolic process | 282/8552 | 489/18723 | 4.70e-08 | 8.50e-07 | 282 |
GO:19016574 | Esophagus | ESCC | glycosyl compound metabolic process | 57/8552 | 88/18723 | 2.32e-04 | 1.44e-03 | 57 |
GO:00725273 | Esophagus | ESCC | pyrimidine-containing compound metabolic process | 52/8552 | 82/18723 | 9.03e-04 | 4.61e-03 | 52 |
GO:00091163 | Esophagus | ESCC | nucleoside metabolic process | 39/8552 | 62/18723 | 4.68e-03 | 1.82e-02 | 39 |
GO:000675312 | Liver | Cirrhotic | nucleoside phosphate metabolic process | 190/4634 | 497/18723 | 1.10e-11 | 6.96e-10 | 190 |
GO:000911712 | Liver | Cirrhotic | nucleotide metabolic process | 187/4634 | 489/18723 | 1.55e-11 | 9.63e-10 | 187 |
GO:00096155 | Liver | Cirrhotic | response to virus | 126/4634 | 367/18723 | 2.10e-05 | 2.77e-04 | 126 |
GO:19016572 | Liver | Cirrhotic | glycosyl compound metabolic process | 37/4634 | 88/18723 | 2.70e-04 | 2.40e-03 | 37 |
GO:001631111 | Liver | Cirrhotic | dephosphorylation | 130/4634 | 417/18723 | 1.58e-03 | 1.03e-02 | 130 |
GO:0009116 | Liver | Cirrhotic | nucleoside metabolic process | 25/4634 | 62/18723 | 4.90e-03 | 2.56e-02 | 25 |
GO:0051607 | Liver | Cirrhotic | defense response to virus | 84/4634 | 265/18723 | 6.02e-03 | 3.00e-02 | 84 |
GO:0140546 | Liver | Cirrhotic | defense response to symbiont | 84/4634 | 265/18723 | 6.02e-03 | 3.00e-02 | 84 |
GO:0072527 | Liver | Cirrhotic | pyrimidine-containing compound metabolic process | 30/4634 | 82/18723 | 1.12e-02 | 4.92e-02 | 30 |
GO:000911722 | Liver | HCC | nucleotide metabolic process | 300/7958 | 489/18723 | 1.61e-17 | 1.71e-15 | 300 |
GO:000675322 | Liver | HCC | nucleoside phosphate metabolic process | 304/7958 | 497/18723 | 1.78e-17 | 1.85e-15 | 304 |
Page: 1 2 3 4 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa012325 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
hsa002405 | Esophagus | ESCC | Pyrimidine metabolism | 41/4205 | 58/8465 | 9.14e-04 | 2.92e-03 | 1.49e-03 | 41 |
hsa0123212 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
hsa0024012 | Esophagus | ESCC | Pyrimidine metabolism | 41/4205 | 58/8465 | 9.14e-04 | 2.92e-03 | 1.49e-03 | 41 |
hsa01232 | Liver | Cirrhotic | Nucleotide metabolism | 39/2530 | 85/8465 | 1.27e-03 | 6.73e-03 | 4.15e-03 | 39 |
hsa00240 | Liver | Cirrhotic | Pyrimidine metabolism | 27/2530 | 58/8465 | 5.31e-03 | 1.88e-02 | 1.16e-02 | 27 |
hsa012321 | Liver | Cirrhotic | Nucleotide metabolism | 39/2530 | 85/8465 | 1.27e-03 | 6.73e-03 | 4.15e-03 | 39 |
hsa002401 | Liver | Cirrhotic | Pyrimidine metabolism | 27/2530 | 58/8465 | 5.31e-03 | 1.88e-02 | 1.16e-02 | 27 |
hsa002402 | Liver | HCC | Pyrimidine metabolism | 44/4020 | 58/8465 | 9.34e-06 | 7.11e-05 | 3.95e-05 | 44 |
hsa012322 | Liver | HCC | Nucleotide metabolism | 59/4020 | 85/8465 | 3.30e-05 | 1.88e-04 | 1.04e-04 | 59 |
hsa002403 | Liver | HCC | Pyrimidine metabolism | 44/4020 | 58/8465 | 9.34e-06 | 7.11e-05 | 3.95e-05 | 44 |
hsa012323 | Liver | HCC | Nucleotide metabolism | 59/4020 | 85/8465 | 3.30e-05 | 1.88e-04 | 1.04e-04 | 59 |
hsa012324 | Oral cavity | OSCC | Nucleotide metabolism | 54/3704 | 85/8465 | 1.78e-04 | 5.95e-04 | 3.03e-04 | 54 |
hsa002404 | Oral cavity | OSCC | Pyrimidine metabolism | 37/3704 | 58/8465 | 1.62e-03 | 4.45e-03 | 2.26e-03 | 37 |
hsa0123211 | Oral cavity | OSCC | Nucleotide metabolism | 54/3704 | 85/8465 | 1.78e-04 | 5.95e-04 | 3.03e-04 | 54 |
hsa0024011 | Oral cavity | OSCC | Pyrimidine metabolism | 37/3704 | 58/8465 | 1.62e-03 | 4.45e-03 | 2.26e-03 | 37 |
hsa0123221 | Oral cavity | LP | Nucleotide metabolism | 42/2418 | 85/8465 | 3.62e-05 | 2.36e-04 | 1.52e-04 | 42 |
hsa0024021 | Oral cavity | LP | Pyrimidine metabolism | 28/2418 | 58/8465 | 1.12e-03 | 5.02e-03 | 3.24e-03 | 28 |
hsa0123231 | Oral cavity | LP | Nucleotide metabolism | 42/2418 | 85/8465 | 3.62e-05 | 2.36e-04 | 1.52e-04 | 42 |
hsa0024031 | Oral cavity | LP | Pyrimidine metabolism | 28/2418 | 58/8465 | 1.12e-03 | 5.02e-03 | 3.24e-03 | 28 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NT5C3A | SNV | Missense_Mutation | rs751646719 | c.760N>T | p.Asp254Tyr | p.D254Y | Q9H0P0 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
NT5C3A | SNV | Missense_Mutation | c.913G>A | p.Asp305Asn | p.D305N | Q9H0P0 | protein_coding | deleterious(0) | possibly_damaging(0.635) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NT5C3A | SNV | Missense_Mutation | c.356N>G | p.Glu119Gly | p.E119G | Q9H0P0 | protein_coding | tolerated(0.11) | possibly_damaging(0.797) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
NT5C3A | SNV | Missense_Mutation | rs772942875 | c.397N>A | p.Ala133Thr | p.A133T | Q9H0P0 | protein_coding | deleterious(0) | possibly_damaging(0.644) | TCGA-AA-3855-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NT5C3A | SNV | Missense_Mutation | c.742C>A | p.His248Asn | p.H248N | Q9H0P0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NT5C3A | SNV | Missense_Mutation | novel | c.831C>A | p.Asp277Glu | p.D277E | Q9H0P0 | protein_coding | deleterious(0) | possibly_damaging(0.808) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
NT5C3A | SNV | Missense_Mutation | c.787N>G | p.Phe263Val | p.F263V | Q9H0P0 | protein_coding | deleterious(0) | possibly_damaging(0.84) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
NT5C3A | insertion | Frame_Shift_Ins | novel | c.709-1_709insATTTTGATGAAACT | p.Gly237IlefsTer15 | p.G237Ifs*15 | Q9H0P0 | protein_coding | TCGA-SS-A7HO-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | oxaliplatin | PD | ||
NT5C3A | SNV | Missense_Mutation | c.518N>G | p.Ile173Ser | p.I173S | Q9H0P0 | protein_coding | tolerated(0.07) | possibly_damaging(0.462) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NT5C3A | SNV | Missense_Mutation | novel | c.281N>A | p.Ser94Asn | p.S94N | Q9H0P0 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AJ-A2QK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
51251 | NT5C3A | ENZYME | cytarabine | CYTARABINE | 25000516 | |
51251 | NT5C3A | ENZYME | idarubicin | IDARUBICIN | 25000516 | |
51251 | NT5C3A | ENZYME | gemcitabine | GEMCITABINE | 22838949 |
Page: 1 |