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Gene: NFU1 |
Gene summary for NFU1 |
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Gene information | Species | Human | Gene symbol | NFU1 | Gene ID | 27247 |
Gene name | NFU1 iron-sulfur cluster scaffold | |
Gene Alias | CGI-33 | |
Cytomap | 2p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006790 | UniProtAcc | Q9UMS0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27247 | NFU1 | P127T-E | Human | Esophagus | ESCC | 4.49e-13 | 4.49e-02 | 0.0826 |
27247 | NFU1 | P128T-E | Human | Esophagus | ESCC | 1.81e-25 | 8.56e-01 | 0.1241 |
27247 | NFU1 | P130T-E | Human | Esophagus | ESCC | 2.10e-64 | 1.42e+00 | 0.1676 |
27247 | NFU1 | S43 | Human | Liver | Cirrhotic | 4.78e-05 | -1.78e-01 | -0.0187 |
27247 | NFU1 | HCC1_Meng | Human | Liver | HCC | 7.38e-86 | 1.60e-01 | 0.0246 |
27247 | NFU1 | HCC2_Meng | Human | Liver | HCC | 2.43e-34 | 1.25e-01 | 0.0107 |
27247 | NFU1 | cirrhotic1 | Human | Liver | Cirrhotic | 8.07e-10 | 2.06e-01 | 0.0202 |
27247 | NFU1 | cirrhotic2 | Human | Liver | Cirrhotic | 6.30e-08 | 1.60e-01 | 0.0201 |
27247 | NFU1 | cirrhotic3 | Human | Liver | Cirrhotic | 8.74e-07 | 1.64e-01 | 0.0215 |
27247 | NFU1 | Pt13.b | Human | Liver | HCC | 5.10e-17 | 2.38e-01 | 0.0251 |
27247 | NFU1 | S014 | Human | Liver | HCC | 1.18e-12 | 5.46e-01 | 0.2254 |
27247 | NFU1 | S015 | Human | Liver | HCC | 3.83e-16 | 8.86e-01 | 0.2375 |
27247 | NFU1 | S016 | Human | Liver | HCC | 2.14e-18 | 8.08e-01 | 0.2243 |
27247 | NFU1 | S027 | Human | Liver | HCC | 2.03e-02 | 7.01e-01 | 0.2446 |
27247 | NFU1 | S028 | Human | Liver | HCC | 1.90e-10 | 5.58e-01 | 0.2503 |
27247 | NFU1 | S029 | Human | Liver | HCC | 6.36e-13 | 7.74e-01 | 0.2581 |
27247 | NFU1 | C04 | Human | Oral cavity | OSCC | 2.58e-11 | 1.09e+00 | 0.2633 |
27247 | NFU1 | C21 | Human | Oral cavity | OSCC | 7.64e-47 | 1.55e+00 | 0.2678 |
27247 | NFU1 | C30 | Human | Oral cavity | OSCC | 1.41e-40 | 1.96e+00 | 0.3055 |
27247 | NFU1 | C38 | Human | Oral cavity | OSCC | 8.24e-13 | 1.41e+00 | 0.172 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005160418 | Esophagus | ESCC | protein maturation | 189/8552 | 294/18723 | 7.64e-11 | 2.39e-09 | 189 |
GO:00067906 | Esophagus | ESCC | sulfur compound metabolic process | 201/8552 | 339/18723 | 2.64e-07 | 3.94e-06 | 201 |
GO:001622611 | Esophagus | ESCC | iron-sulfur cluster assembly | 21/8552 | 26/18723 | 2.69e-04 | 1.63e-03 | 21 |
GO:003116311 | Esophagus | ESCC | metallo-sulfur cluster assembly | 21/8552 | 26/18723 | 2.69e-04 | 1.63e-03 | 21 |
GO:009742811 | Esophagus | ESCC | protein maturation by iron-sulfur cluster transfer | 14/8552 | 16/18723 | 6.78e-04 | 3.56e-03 | 14 |
GO:00516046 | Liver | Cirrhotic | protein maturation | 121/4634 | 294/18723 | 3.54e-10 | 1.68e-08 | 121 |
GO:000679011 | Liver | Cirrhotic | sulfur compound metabolic process | 129/4634 | 339/18723 | 3.06e-08 | 1.04e-06 | 129 |
GO:000679021 | Liver | HCC | sulfur compound metabolic process | 212/7958 | 339/18723 | 5.60e-14 | 3.39e-12 | 212 |
GO:005160412 | Liver | HCC | protein maturation | 171/7958 | 294/18723 | 3.80e-08 | 8.30e-07 | 171 |
GO:0016226 | Liver | HCC | iron-sulfur cluster assembly | 18/7958 | 26/18723 | 5.37e-03 | 2.24e-02 | 18 |
GO:0031163 | Liver | HCC | metallo-sulfur cluster assembly | 18/7958 | 26/18723 | 5.37e-03 | 2.24e-02 | 18 |
GO:005160410 | Oral cavity | OSCC | protein maturation | 170/7305 | 294/18723 | 3.97e-11 | 1.28e-09 | 170 |
GO:00067905 | Oral cavity | OSCC | sulfur compound metabolic process | 168/7305 | 339/18723 | 4.50e-05 | 3.84e-04 | 168 |
GO:00162262 | Oral cavity | OSCC | iron-sulfur cluster assembly | 19/7305 | 26/18723 | 4.46e-04 | 2.70e-03 | 19 |
GO:00311632 | Oral cavity | OSCC | metallo-sulfur cluster assembly | 19/7305 | 26/18723 | 4.46e-04 | 2.70e-03 | 19 |
GO:0097428 | Oral cavity | OSCC | protein maturation by iron-sulfur cluster transfer | 11/7305 | 16/18723 | 1.56e-02 | 4.99e-02 | 11 |
GO:005160416 | Oral cavity | LP | protein maturation | 122/4623 | 294/18723 | 1.37e-10 | 7.72e-09 | 122 |
GO:00162261 | Oral cavity | LP | iron-sulfur cluster assembly | 15/4623 | 26/18723 | 3.34e-04 | 3.34e-03 | 15 |
GO:00311631 | Oral cavity | LP | metallo-sulfur cluster assembly | 15/4623 | 26/18723 | 3.34e-04 | 3.34e-03 | 15 |
GO:000679012 | Oral cavity | LP | sulfur compound metabolic process | 106/4623 | 339/18723 | 3.36e-03 | 2.25e-02 | 106 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NFU1 | SNV | Missense_Mutation | c.473N>T | p.Ser158Leu | p.S158L | Q9UMS0 | protein_coding | tolerated(0.11) | benign(0.027) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD | |
NFU1 | SNV | Missense_Mutation | c.516G>A | p.Met172Ile | p.M172I | Q9UMS0 | protein_coding | deleterious(0.03) | possibly_damaging(0.566) | TCGA-IR-A3LL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
NFU1 | SNV | Missense_Mutation | novel | c.748N>C | p.Glu250Gln | p.E250Q | Q9UMS0 | protein_coding | tolerated(0.14) | benign(0.003) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NFU1 | SNV | Missense_Mutation | c.354C>A | p.Phe118Leu | p.F118L | Q9UMS0 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
NFU1 | SNV | Missense_Mutation | c.163N>T | p.Pro55Ser | p.P55S | Q9UMS0 | protein_coding | tolerated(0.56) | benign(0.001) | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
NFU1 | SNV | Missense_Mutation | c.545N>A | p.Arg182Gln | p.R182Q | Q9UMS0 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-A5-A2K7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD | |
NFU1 | SNV | Missense_Mutation | novel | c.328N>C | p.Lys110Gln | p.K110Q | Q9UMS0 | protein_coding | tolerated(0.06) | possibly_damaging(0.733) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
NFU1 | SNV | Missense_Mutation | c.339N>A | p.Phe113Leu | p.F113L | Q9UMS0 | protein_coding | deleterious(0.03) | possibly_damaging(0.859) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
NFU1 | SNV | Missense_Mutation | novel | c.143T>C | p.Leu48Pro | p.L48P | Q9UMS0 | protein_coding | tolerated(0.28) | benign(0) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
NFU1 | SNV | Missense_Mutation | novel | c.599N>T | p.Gly200Val | p.G200V | Q9UMS0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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