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Gene: NDUFB8 |
Gene summary for NDUFB8 |
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Gene information | Species | Human | Gene symbol | NDUFB8 | Gene ID | 4714 |
Gene name | NADH:ubiquinone oxidoreductase subunit B8 | |
Gene Alias | ASHI | |
Cytomap | 10q24.31 | |
Gene Type | protein-coding | GO ID | GO:0006091 | UniProtAcc | O95169 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4714 | NDUFB8 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 5.77e-30 | -3.93e-01 | -0.1869 |
4714 | NDUFB8 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 2.91e-28 | -4.35e-01 | -0.1875 |
4714 | NDUFB8 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 4.20e-34 | -6.10e-01 | -0.1883 |
4714 | NDUFB8 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 2.71e-30 | -3.80e-01 | -0.1934 |
4714 | NDUFB8 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 2.25e-53 | -5.02e-01 | -0.1917 |
4714 | NDUFB8 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 7.03e-45 | -5.72e-01 | -0.1916 |
4714 | NDUFB8 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 9.84e-09 | -2.27e-01 | -0.1269 |
4714 | NDUFB8 | LZE2T | Human | Esophagus | ESCC | 4.85e-08 | 1.23e+00 | 0.082 |
4714 | NDUFB8 | LZE4T | Human | Esophagus | ESCC | 4.55e-22 | 9.53e-01 | 0.0811 |
4714 | NDUFB8 | LZE5T | Human | Esophagus | ESCC | 2.23e-04 | 7.91e-01 | 0.0514 |
4714 | NDUFB8 | LZE7T | Human | Esophagus | ESCC | 2.41e-16 | 1.03e+00 | 0.0667 |
4714 | NDUFB8 | LZE8T | Human | Esophagus | ESCC | 1.01e-20 | 8.72e-01 | 0.067 |
4714 | NDUFB8 | LZE20T | Human | Esophagus | ESCC | 1.39e-08 | 5.41e-01 | 0.0662 |
4714 | NDUFB8 | LZE22T | Human | Esophagus | ESCC | 6.49e-03 | 6.62e-01 | 0.068 |
4714 | NDUFB8 | LZE24T | Human | Esophagus | ESCC | 1.29e-48 | 1.70e+00 | 0.0596 |
4714 | NDUFB8 | LZE21T | Human | Esophagus | ESCC | 3.76e-05 | 8.02e-01 | 0.0655 |
4714 | NDUFB8 | LZE6T | Human | Esophagus | ESCC | 5.45e-14 | 8.72e-01 | 0.0845 |
4714 | NDUFB8 | P1T-E | Human | Esophagus | ESCC | 1.94e-03 | -1.52e-01 | 0.0875 |
4714 | NDUFB8 | P2T-E | Human | Esophagus | ESCC | 3.52e-14 | 1.29e-01 | 0.1177 |
4714 | NDUFB8 | P4T-E | Human | Esophagus | ESCC | 1.55e-20 | 3.99e-01 | 0.1323 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004603410 | Cervix | CC | ATP metabolic process | 90/2311 | 277/18723 | 7.90e-19 | 2.36e-15 | 90 |
GO:000611910 | Cervix | CC | oxidative phosphorylation | 55/2311 | 141/18723 | 7.12e-16 | 1.42e-12 | 55 |
GO:00090609 | Cervix | CC | aerobic respiration | 60/2311 | 189/18723 | 1.59e-12 | 6.36e-10 | 60 |
GO:00427739 | Cervix | CC | ATP synthesis coupled electron transport | 38/2311 | 95/18723 | 8.45e-12 | 2.66e-09 | 38 |
GO:00427759 | Cervix | CC | mitochondrial ATP synthesis coupled electron transport | 38/2311 | 95/18723 | 8.45e-12 | 2.66e-09 | 38 |
GO:00196469 | Cervix | CC | aerobic electron transport chain | 36/2311 | 87/18723 | 9.15e-12 | 2.74e-09 | 36 |
GO:00229049 | Cervix | CC | respiratory electron transport chain | 42/2311 | 114/18723 | 1.67e-11 | 4.77e-09 | 42 |
GO:00453339 | Cervix | CC | cellular respiration | 66/2311 | 230/18723 | 2.07e-11 | 5.39e-09 | 66 |
GO:00229009 | Cervix | CC | electron transport chain | 53/2311 | 175/18723 | 2.23e-10 | 3.43e-08 | 53 |
GO:00060919 | Cervix | CC | generation of precursor metabolites and energy | 105/2311 | 490/18723 | 7.40e-09 | 6.61e-07 | 105 |
GO:00159809 | Cervix | CC | energy derivation by oxidation of organic compounds | 74/2311 | 318/18723 | 3.83e-08 | 2.53e-06 | 74 |
GO:00061209 | Cervix | CC | mitochondrial electron transport, NADH to ubiquinone | 22/2311 | 51/18723 | 4.01e-08 | 2.54e-06 | 22 |
GO:00102579 | Cervix | CC | NADH dehydrogenase complex assembly | 22/2311 | 57/18723 | 4.28e-07 | 1.67e-05 | 22 |
GO:00329819 | Cervix | CC | mitochondrial respiratory chain complex I assembly | 22/2311 | 57/18723 | 4.28e-07 | 1.67e-05 | 22 |
GO:00331089 | Cervix | CC | mitochondrial respiratory chain complex assembly | 26/2311 | 93/18723 | 3.97e-05 | 6.18e-04 | 26 |
GO:004603415 | Cervix | HSIL_HPV | ATP metabolic process | 36/737 | 277/18723 | 3.06e-10 | 7.02e-08 | 36 |
GO:000611914 | Cervix | HSIL_HPV | oxidative phosphorylation | 23/737 | 141/18723 | 6.76e-09 | 8.80e-07 | 23 |
GO:001964614 | Cervix | HSIL_HPV | aerobic electron transport chain | 15/737 | 87/18723 | 1.38e-06 | 6.26e-05 | 15 |
GO:000906014 | Cervix | HSIL_HPV | aerobic respiration | 23/737 | 189/18723 | 1.59e-06 | 6.90e-05 | 23 |
GO:004277314 | Cervix | HSIL_HPV | ATP synthesis coupled electron transport | 15/737 | 95/18723 | 4.31e-06 | 1.70e-04 | 15 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0520820 | Cervix | CC | Chemical carcinogenesis - reactive oxygen species | 92/1267 | 223/8465 | 4.71e-22 | 5.09e-20 | 3.01e-20 | 92 |
hsa0501220 | Cervix | CC | Parkinson disease | 102/1267 | 266/8465 | 1.81e-21 | 1.47e-19 | 8.66e-20 | 102 |
hsa0019018 | Cervix | CC | Oxidative phosphorylation | 64/1267 | 134/8465 | 1.25e-19 | 8.07e-18 | 4.77e-18 | 64 |
hsa0502018 | Cervix | CC | Prion disease | 98/1267 | 273/8465 | 2.64e-18 | 1.42e-16 | 8.42e-17 | 98 |
hsa0541520 | Cervix | CC | Diabetic cardiomyopathy | 76/1267 | 203/8465 | 1.40e-15 | 6.46e-14 | 3.82e-14 | 76 |
hsa0501018 | Cervix | CC | Alzheimer disease | 113/1267 | 384/8465 | 9.67e-14 | 3.92e-12 | 2.32e-12 | 113 |
hsa0501618 | Cervix | CC | Huntington disease | 94/1267 | 306/8465 | 8.49e-13 | 3.06e-11 | 1.81e-11 | 94 |
hsa0502218 | Cervix | CC | Pathways of neurodegeneration - multiple diseases | 128/1267 | 476/8465 | 2.87e-12 | 9.29e-11 | 5.50e-11 | 128 |
hsa0493218 | Cervix | CC | Non-alcoholic fatty liver disease | 58/1267 | 155/8465 | 3.58e-12 | 1.05e-10 | 6.23e-11 | 58 |
hsa0471420 | Cervix | CC | Thermogenesis | 76/1267 | 232/8465 | 4.29e-12 | 1.16e-10 | 6.85e-11 | 76 |
hsa0501418 | Cervix | CC | Amyotrophic lateral sclerosis | 103/1267 | 364/8465 | 1.79e-11 | 4.47e-10 | 2.64e-10 | 103 |
hsa0472318 | Cervix | CC | Retrograde endocannabinoid signaling | 42/1267 | 148/8465 | 1.79e-05 | 1.42e-04 | 8.40e-05 | 42 |
hsa05208110 | Cervix | CC | Chemical carcinogenesis - reactive oxygen species | 92/1267 | 223/8465 | 4.71e-22 | 5.09e-20 | 3.01e-20 | 92 |
hsa05012110 | Cervix | CC | Parkinson disease | 102/1267 | 266/8465 | 1.81e-21 | 1.47e-19 | 8.66e-20 | 102 |
hsa0019019 | Cervix | CC | Oxidative phosphorylation | 64/1267 | 134/8465 | 1.25e-19 | 8.07e-18 | 4.77e-18 | 64 |
hsa0502019 | Cervix | CC | Prion disease | 98/1267 | 273/8465 | 2.64e-18 | 1.42e-16 | 8.42e-17 | 98 |
hsa05415110 | Cervix | CC | Diabetic cardiomyopathy | 76/1267 | 203/8465 | 1.40e-15 | 6.46e-14 | 3.82e-14 | 76 |
hsa0501019 | Cervix | CC | Alzheimer disease | 113/1267 | 384/8465 | 9.67e-14 | 3.92e-12 | 2.32e-12 | 113 |
hsa0501619 | Cervix | CC | Huntington disease | 94/1267 | 306/8465 | 8.49e-13 | 3.06e-11 | 1.81e-11 | 94 |
hsa0502219 | Cervix | CC | Pathways of neurodegeneration - multiple diseases | 128/1267 | 476/8465 | 2.87e-12 | 9.29e-11 | 5.50e-11 | 128 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NDUFB8 | SNV | Missense_Mutation | rs200080913 | c.347G>A | p.Arg116His | p.R116H | O95169 | protein_coding | deleterious(0) | benign(0.391) | TCGA-B6-A0I1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
NDUFB8 | SNV | Missense_Mutation | novel | c.491N>C | p.Asn164Thr | p.N164T | O95169 | protein_coding | deleterious(0.03) | benign(0.159) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
NDUFB8 | SNV | Missense_Mutation | rs371166959 | c.169A>C | p.Met57Leu | p.M57L | O95169 | protein_coding | tolerated(0.64) | benign(0.058) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NDUFB8 | insertion | In_Frame_Ins | novel | c.154_156dupGCC | p.Ala52dup | p.A52dup | O95169 | protein_coding | TCGA-CM-6677-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
NDUFB8 | SNV | Missense_Mutation | rs150699698 | c.346N>T | p.Arg116Cys | p.R116C | O95169 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
NDUFB8 | SNV | Missense_Mutation | c.443N>G | p.Asp148Gly | p.D148G | O95169 | protein_coding | deleterious(0.05) | benign(0.167) | TCGA-BK-A0C9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NDUFB8 | SNV | Missense_Mutation | rs775076125 | c.538C>T | p.Arg180Trp | p.R180W | O95169 | protein_coding | deleterious(0.01) | benign(0.05) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NDUFB8 | SNV | Missense_Mutation | rs375681068 | c.241N>T | p.Arg81Cys | p.R81C | O95169 | protein_coding | tolerated(0.09) | benign(0.125) | TCGA-D1-A101-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NDUFB8 | SNV | Missense_Mutation | novel | c.70N>A | p.Leu24Met | p.L24M | O95169 | protein_coding | tolerated(0.09) | possibly_damaging(0.849) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
NDUFB8 | SNV | Missense_Mutation | novel | c.374N>A | p.Ser125Tyr | p.S125Y | O95169 | protein_coding | tolerated(0.09) | possibly_damaging(0.879) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4714 | NDUFB8 | ENZYME | inhibitor | CHEMBL3545320 | ME-344 | |
4714 | NDUFB8 | ENZYME | inhibitor | CHEMBL1703 | METFORMIN HYDROCHLORIDE | |
4714 | NDUFB8 | ENZYME | inhibitor | CHEMBL3545135 | NV-128 |
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