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Gene: MZT2B |
Gene summary for MZT2B |
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Gene information | Species | Human | Gene symbol | MZT2B | Gene ID | 80097 |
Gene name | mitotic spindle organizing protein 2B | |
Gene Alias | FAM128B | |
Cytomap | 2q21.1 | |
Gene Type | protein-coding | GO ID | GO:0000930 | UniProtAcc | B8ZZ87 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80097 | MZT2B | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.04e-04 | 3.28e-01 | 0.3859 |
80097 | MZT2B | HTA11_99999974143_84620 | Human | Colorectum | MSS | 8.13e-11 | 4.42e-01 | 0.3005 |
80097 | MZT2B | AEH-subject1 | Human | Endometrium | AEH | 1.65e-31 | -6.76e-01 | -0.3059 |
80097 | MZT2B | AEH-subject2 | Human | Endometrium | AEH | 1.30e-28 | -6.47e-01 | -0.2525 |
80097 | MZT2B | AEH-subject3 | Human | Endometrium | AEH | 7.57e-27 | -6.43e-01 | -0.2576 |
80097 | MZT2B | AEH-subject4 | Human | Endometrium | AEH | 1.60e-33 | -7.94e-01 | -0.2657 |
80097 | MZT2B | AEH-subject5 | Human | Endometrium | AEH | 2.95e-34 | -7.62e-01 | -0.2953 |
80097 | MZT2B | EEC-subject1 | Human | Endometrium | EEC | 7.92e-25 | -5.83e-01 | -0.2682 |
80097 | MZT2B | EEC-subject2 | Human | Endometrium | EEC | 1.53e-21 | -6.28e-01 | -0.2607 |
80097 | MZT2B | EEC-subject3 | Human | Endometrium | EEC | 4.98e-62 | -8.55e-01 | -0.2525 |
80097 | MZT2B | EEC-subject4 | Human | Endometrium | EEC | 1.23e-18 | -5.80e-01 | -0.2571 |
80097 | MZT2B | EEC-subject5 | Human | Endometrium | EEC | 1.77e-19 | -5.66e-01 | -0.249 |
80097 | MZT2B | GSM5276934 | Human | Endometrium | EEC | 3.05e-09 | -3.89e-01 | -0.0913 |
80097 | MZT2B | GSM5276935 | Human | Endometrium | EEC | 4.86e-02 | -2.05e-01 | -0.123 |
80097 | MZT2B | GSM5276937 | Human | Endometrium | EEC | 4.34e-12 | -3.50e-01 | -0.0897 |
80097 | MZT2B | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 3.57e-52 | -8.62e-01 | -0.1869 |
80097 | MZT2B | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 9.47e-50 | -9.60e-01 | -0.1875 |
80097 | MZT2B | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 1.53e-61 | -1.01e+00 | -0.1883 |
80097 | MZT2B | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 3.01e-46 | -7.37e-01 | -0.1934 |
80097 | MZT2B | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 1.53e-72 | -1.06e+00 | -0.1917 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MZT2B | SNV | Missense_Mutation | rs773776345 | c.550N>T | p.Arg184Cys | p.R184C | protein_coding | tolerated(0.09) | benign(0.003) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MZT2B | insertion | Frame_Shift_Ins | rs772879277 | c.614_615insG | p.Gly208ArgfsTer34 | p.G208Rfs*34 | protein_coding | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |||
MZT2B | insertion | Frame_Shift_Ins | novel | c.29_30insG | p.Ser12ValfsTer106 | p.S12Vfs*106 | protein_coding | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
MZT2B | SNV | Missense_Mutation | rs773776345 | c.550N>T | p.Arg184Cys | p.R184C | protein_coding | tolerated(0.09) | benign(0.003) | TCGA-A5-A2K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD | |
MZT2B | SNV | Missense_Mutation | novel | c.466N>T | p.Arg156Cys | p.R156C | protein_coding | tolerated(0.13) | possibly_damaging(0.685) | TCGA-AJ-A3BG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | |
MZT2B | SNV | Missense_Mutation | novel | c.275N>A | p.Pro92His | p.P92H | protein_coding | deleterious(0.01) | probably_damaging(0.937) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MZT2B | SNV | Missense_Mutation | rs1043073 | c.560N>A | p.Arg187His | p.R187H | protein_coding | deleterious(0.01) | possibly_damaging(0.86) | TCGA-BS-A0V4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MZT2B | SNV | Missense_Mutation | novel | c.427N>G | p.Thr143Ala | p.T143A | protein_coding | tolerated(0.58) | benign(0.224) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | |
MZT2B | insertion | Frame_Shift_Ins | rs772879277 | c.614_615insG | p.Gly208ArgfsTer34 | p.G208Rfs*34 | protein_coding | TCGA-D1-A177-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |||
MZT2B | insertion | Frame_Shift_Ins | novel | c.455_456insT | p.Ser154PhefsTer88 | p.S154Ffs*88 | protein_coding | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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