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Gene: MPHOSPH10 |
Gene summary for MPHOSPH10 |
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Gene information | Species | Human | Gene symbol | MPHOSPH10 | Gene ID | 10199 |
Gene name | M-phase phosphoprotein 10 | |
Gene Alias | CT90 | |
Cytomap | 2p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | O00566 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10199 | MPHOSPH10 | P104T-E | Human | Esophagus | ESCC | 1.94e-04 | 3.17e-01 | 0.0931 |
10199 | MPHOSPH10 | P107T-E | Human | Esophagus | ESCC | 5.92e-42 | 9.13e-01 | 0.171 |
10199 | MPHOSPH10 | P126T-E | Human | Esophagus | ESCC | 1.31e-09 | 6.82e-01 | 0.1125 |
10199 | MPHOSPH10 | P127T-E | Human | Esophagus | ESCC | 3.24e-16 | 2.44e-01 | 0.0826 |
10199 | MPHOSPH10 | P128T-E | Human | Esophagus | ESCC | 1.29e-31 | 1.18e+00 | 0.1241 |
10199 | MPHOSPH10 | P130T-E | Human | Esophagus | ESCC | 6.38e-53 | 1.09e+00 | 0.1676 |
10199 | MPHOSPH10 | HCC1_Meng | Human | Liver | HCC | 1.03e-79 | 2.02e-01 | 0.0246 |
10199 | MPHOSPH10 | HCC2_Meng | Human | Liver | HCC | 5.92e-14 | 5.98e-02 | 0.0107 |
10199 | MPHOSPH10 | cirrhotic1 | Human | Liver | Cirrhotic | 1.41e-06 | 2.00e-01 | 0.0202 |
10199 | MPHOSPH10 | HCC1 | Human | Liver | HCC | 3.36e-04 | 3.70e+00 | 0.5336 |
10199 | MPHOSPH10 | HCC2 | Human | Liver | HCC | 8.67e-15 | 4.40e+00 | 0.5341 |
10199 | MPHOSPH10 | Pt13.b | Human | Liver | HCC | 2.16e-11 | 1.95e-01 | 0.0251 |
10199 | MPHOSPH10 | S014 | Human | Liver | HCC | 8.08e-10 | 5.17e-01 | 0.2254 |
10199 | MPHOSPH10 | S015 | Human | Liver | HCC | 2.30e-16 | 7.27e-01 | 0.2375 |
10199 | MPHOSPH10 | S016 | Human | Liver | HCC | 7.47e-11 | 5.38e-01 | 0.2243 |
10199 | MPHOSPH10 | S027 | Human | Liver | HCC | 9.20e-06 | 7.82e-01 | 0.2446 |
10199 | MPHOSPH10 | S028 | Human | Liver | HCC | 1.63e-19 | 8.85e-01 | 0.2503 |
10199 | MPHOSPH10 | S029 | Human | Liver | HCC | 1.03e-08 | 8.05e-01 | 0.2581 |
10199 | MPHOSPH10 | C04 | Human | Oral cavity | OSCC | 3.61e-11 | 8.31e-01 | 0.2633 |
10199 | MPHOSPH10 | C21 | Human | Oral cavity | OSCC | 3.62e-38 | 1.26e+00 | 0.2678 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:0000375111 | Esophagus | ESCC | RNA splicing, via transesterification reactions | 248/8552 | 324/18723 | 3.05e-30 | 1.49e-27 | 248 |
GO:000838012 | Liver | Cirrhotic | RNA splicing | 229/4634 | 434/18723 | 9.13e-37 | 2.86e-33 | 229 |
GO:002261312 | Liver | Cirrhotic | ribonucleoprotein complex biogenesis | 231/4634 | 463/18723 | 3.28e-32 | 6.86e-29 | 231 |
GO:000037512 | Liver | Cirrhotic | RNA splicing, via transesterification reactions | 175/4634 | 324/18723 | 5.95e-30 | 7.47e-27 | 175 |
GO:004225412 | Liver | Cirrhotic | ribosome biogenesis | 154/4634 | 299/18723 | 1.18e-23 | 6.72e-21 | 154 |
GO:000636412 | Liver | Cirrhotic | rRNA processing | 115/4634 | 225/18723 | 1.12e-17 | 1.64e-15 | 115 |
GO:00160724 | Liver | Cirrhotic | rRNA metabolic process | 119/4634 | 236/18723 | 1.19e-17 | 1.70e-15 | 119 |
GO:00344701 | Liver | Cirrhotic | ncRNA processing | 158/4634 | 395/18723 | 1.09e-11 | 6.96e-10 | 158 |
GO:00346603 | Liver | Cirrhotic | ncRNA metabolic process | 173/4634 | 485/18723 | 3.64e-08 | 1.21e-06 | 173 |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
GO:004225422 | Liver | HCC | ribosome biogenesis | 246/7958 | 299/18723 | 4.99e-46 | 1.58e-42 | 246 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:000838022 | Liver | HCC | RNA splicing | 313/7958 | 434/18723 | 1.36e-36 | 1.73e-33 | 313 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MPHOSPH10 | SNV | Missense_Mutation | c.1847N>T | p.Ser616Leu | p.S616L | O00566 | protein_coding | tolerated(0.43) | benign(0.011) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MPHOSPH10 | SNV | Missense_Mutation | c.331G>A | p.Glu111Lys | p.E111K | O00566 | protein_coding | tolerated(0.29) | possibly_damaging(0.883) | TCGA-AN-A0FS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MPHOSPH10 | SNV | Missense_Mutation | c.567N>C | p.Lys189Asn | p.K189N | O00566 | protein_coding | tolerated(0.12) | benign(0.129) | TCGA-BH-A0BZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | CR | |
MPHOSPH10 | SNV | Missense_Mutation | rs746074531 | c.1460A>C | p.Glu487Ala | p.E487A | O00566 | protein_coding | deleterious(0.02) | possibly_damaging(0.906) | TCGA-E2-A574-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
MPHOSPH10 | SNV | Missense_Mutation | c.839C>A | p.Thr280Lys | p.T280K | O00566 | protein_coding | tolerated(0.86) | benign(0.061) | TCGA-GI-A2C8-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | Adriamycin | SD | |
MPHOSPH10 | insertion | Frame_Shift_Ins | novel | c.1793_1794insCTTACACAGTAATAATGGTTTCTGCCAGGTGCTCATCTTCCTGGCTG | p.Glu600HisfsTer21 | p.E600Hfs*21 | O00566 | protein_coding | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD | ||
MPHOSPH10 | insertion | Frame_Shift_Ins | novel | c.1362_1363insA | p.Arg457AlafsTer7 | p.R457Afs*7 | O00566 | protein_coding | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MPHOSPH10 | insertion | In_Frame_Ins | novel | c.1536_1537insAAA | p.Asn512_Phe513insLys | p.N512_F513insK | O00566 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MPHOSPH10 | insertion | In_Frame_Ins | novel | c.1537_1538insACATGTACATGGCACTATTAACAG | p.Phe513delinsTyrMetTyrMetAlaLeuLeuThrVal | p.F513delinsYMYMALLTV | O00566 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MPHOSPH10 | SNV | Missense_Mutation | novel | c.377A>G | p.Asp126Gly | p.D126G | O00566 | protein_coding | tolerated(0.74) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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