![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: MORN2 |
Gene summary for MORN2 |
![]() |
Gene information | Species | Human | Gene symbol | MORN2 | Gene ID | 729967 |
Gene name | MORN repeat containing 2 | |
Gene Alias | BLOCK27 | |
Cytomap | 2p22.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q502X0 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
729967 | MORN2 | P107T-E | Human | Esophagus | ESCC | 2.75e-37 | 8.35e-01 | 0.171 |
729967 | MORN2 | P126T-E | Human | Esophagus | ESCC | 1.45e-17 | 8.09e-01 | 0.1125 |
729967 | MORN2 | P127T-E | Human | Esophagus | ESCC | 1.00e-11 | 3.32e-01 | 0.0826 |
729967 | MORN2 | P128T-E | Human | Esophagus | ESCC | 2.33e-47 | 1.24e+00 | 0.1241 |
729967 | MORN2 | P130T-E | Human | Esophagus | ESCC | 4.03e-46 | 9.63e-01 | 0.1676 |
729967 | MORN2 | S43 | Human | Liver | Cirrhotic | 4.57e-04 | -2.34e-01 | -0.0187 |
729967 | MORN2 | HCC1_Meng | Human | Liver | HCC | 6.40e-72 | -6.25e-02 | 0.0246 |
729967 | MORN2 | HCC2_Meng | Human | Liver | HCC | 6.17e-28 | -1.35e-03 | 0.0107 |
729967 | MORN2 | cirrhotic1 | Human | Liver | Cirrhotic | 2.47e-19 | 2.39e-01 | 0.0202 |
729967 | MORN2 | cirrhotic2 | Human | Liver | Cirrhotic | 1.97e-13 | 1.97e-01 | 0.0201 |
729967 | MORN2 | cirrhotic3 | Human | Liver | Cirrhotic | 2.35e-08 | 5.85e-02 | 0.0215 |
729967 | MORN2 | HCC2 | Human | Liver | HCC | 2.08e-03 | 3.67e+00 | 0.5341 |
729967 | MORN2 | Pt13.b | Human | Liver | HCC | 1.67e-06 | -8.27e-02 | 0.0251 |
729967 | MORN2 | S014 | Human | Liver | HCC | 9.96e-18 | 8.06e-01 | 0.2254 |
729967 | MORN2 | S015 | Human | Liver | HCC | 3.29e-16 | 1.02e+00 | 0.2375 |
729967 | MORN2 | S016 | Human | Liver | HCC | 1.26e-20 | 8.64e-01 | 0.2243 |
729967 | MORN2 | S028 | Human | Liver | HCC | 1.75e-09 | 6.62e-01 | 0.2503 |
729967 | MORN2 | S029 | Human | Liver | HCC | 1.99e-06 | 5.46e-01 | 0.2581 |
729967 | MORN2 | C04 | Human | Oral cavity | OSCC | 5.69e-24 | 1.39e+00 | 0.2633 |
729967 | MORN2 | C21 | Human | Oral cavity | OSCC | 9.16e-20 | 6.62e-01 | 0.2678 |
Page: 1 2 3 4 5 6 7 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MORN2 | SNV | Missense_Mutation | novel | c.223N>G | p.Leu75Val | p.L75V | Q502X0 | protein_coding | tolerated(0.28) | benign(0.194) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MORN2 | insertion | Frame_Shift_Ins | novel | c.106dupG | p.Ala36GlyfsTer9 | p.A36Gfs*9 | Q502X0 | protein_coding | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
MORN2 | SNV | Missense_Mutation | novel | c.24N>T | p.Glu8Asp | p.E8D | Q502X0 | protein_coding | tolerated(0.12) | benign(0.073) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |