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Gene: MICU2 |
Gene summary for MICU2 |
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Gene information | Species | Human | Gene symbol | MICU2 | Gene ID | 221154 |
Gene name | mitochondrial calcium uptake 2 | |
Gene Alias | 1110008L20Rik | |
Cytomap | 13q12.11 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A0S2Z6V5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
221154 | MICU2 | P126T-E | Human | Esophagus | ESCC | 7.78e-04 | 4.64e-01 | 0.1125 |
221154 | MICU2 | P127T-E | Human | Esophagus | ESCC | 9.65e-15 | 1.23e-01 | 0.0826 |
221154 | MICU2 | P128T-E | Human | Esophagus | ESCC | 1.15e-20 | 5.87e-01 | 0.1241 |
221154 | MICU2 | P130T-E | Human | Esophagus | ESCC | 3.69e-28 | 6.58e-01 | 0.1676 |
221154 | MICU2 | NAFLD1 | Human | Liver | NAFLD | 1.46e-04 | 6.40e-01 | -0.04 |
221154 | MICU2 | HCC1_Meng | Human | Liver | HCC | 6.46e-58 | -8.06e-03 | 0.0246 |
221154 | MICU2 | HCC2_Meng | Human | Liver | HCC | 3.50e-22 | 1.73e-02 | 0.0107 |
221154 | MICU2 | cirrhotic2 | Human | Liver | Cirrhotic | 4.33e-06 | 1.50e-01 | 0.0201 |
221154 | MICU2 | S014 | Human | Liver | HCC | 8.40e-03 | 3.08e-01 | 0.2254 |
221154 | MICU2 | S015 | Human | Liver | HCC | 1.24e-08 | 5.59e-01 | 0.2375 |
221154 | MICU2 | S016 | Human | Liver | HCC | 1.82e-06 | 4.10e-01 | 0.2243 |
221154 | MICU2 | S028 | Human | Liver | HCC | 1.13e-04 | 4.10e-01 | 0.2503 |
221154 | MICU2 | S029 | Human | Liver | HCC | 3.02e-08 | 5.90e-01 | 0.2581 |
221154 | MICU2 | C04 | Human | Oral cavity | OSCC | 1.65e-04 | 4.68e-01 | 0.2633 |
221154 | MICU2 | C21 | Human | Oral cavity | OSCC | 9.14e-10 | 4.67e-01 | 0.2678 |
221154 | MICU2 | C30 | Human | Oral cavity | OSCC | 1.32e-27 | 1.08e+00 | 0.3055 |
221154 | MICU2 | C43 | Human | Oral cavity | OSCC | 1.98e-21 | 3.98e-01 | 0.1704 |
221154 | MICU2 | C46 | Human | Oral cavity | OSCC | 1.35e-02 | 1.75e-01 | 0.1673 |
221154 | MICU2 | C51 | Human | Oral cavity | OSCC | 1.42e-02 | 2.80e-01 | 0.2674 |
221154 | MICU2 | C06 | Human | Oral cavity | OSCC | 2.03e-03 | 7.98e-01 | 0.2699 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000683920 | Esophagus | HGIN | mitochondrial transport | 74/2587 | 254/18723 | 1.32e-10 | 1.32e-08 | 74 |
GO:199054220 | Esophagus | HGIN | mitochondrial transmembrane transport | 29/2587 | 102/18723 | 8.52e-05 | 1.87e-03 | 29 |
GO:0006839110 | Esophagus | ESCC | mitochondrial transport | 187/8552 | 254/18723 | 8.35e-20 | 9.81e-18 | 187 |
GO:1990542110 | Esophagus | ESCC | mitochondrial transmembrane transport | 72/8552 | 102/18723 | 2.94e-07 | 4.23e-06 | 72 |
GO:00515613 | Liver | NAFLD | positive regulation of mitochondrial calcium ion concentration | 5/1882 | 11/18723 | 2.81e-03 | 2.55e-02 | 5 |
GO:00515605 | Liver | NAFLD | mitochondrial calcium ion homeostasis | 8/1882 | 26/18723 | 3.06e-03 | 2.75e-02 | 8 |
GO:00068397 | Liver | Cirrhotic | mitochondrial transport | 112/4634 | 254/18723 | 1.03e-11 | 6.66e-10 | 112 |
GO:005156011 | Liver | Cirrhotic | mitochondrial calcium ion homeostasis | 15/4634 | 26/18723 | 3.43e-04 | 2.93e-03 | 15 |
GO:19905425 | Liver | Cirrhotic | mitochondrial transmembrane transport | 41/4634 | 102/18723 | 4.08e-04 | 3.37e-03 | 41 |
GO:005156111 | Liver | Cirrhotic | positive regulation of mitochondrial calcium ion concentration | 8/4634 | 11/18723 | 1.10e-03 | 7.64e-03 | 8 |
GO:00364444 | Liver | Cirrhotic | calcium import into the mitochondrion | 8/4634 | 14/18723 | 9.65e-03 | 4.35e-02 | 8 |
GO:000683912 | Liver | HCC | mitochondrial transport | 184/7958 | 254/18723 | 2.30e-22 | 3.83e-20 | 184 |
GO:199054212 | Liver | HCC | mitochondrial transmembrane transport | 78/7958 | 102/18723 | 2.73e-12 | 1.26e-10 | 78 |
GO:003644411 | Liver | HCC | calcium import into the mitochondrion | 13/7958 | 14/18723 | 1.25e-04 | 1.03e-03 | 13 |
GO:005156021 | Liver | HCC | mitochondrial calcium ion homeostasis | 20/7958 | 26/18723 | 3.82e-04 | 2.61e-03 | 20 |
GO:00068513 | Liver | HCC | mitochondrial calcium ion transmembrane transport | 16/7958 | 20/18723 | 7.15e-04 | 4.37e-03 | 16 |
GO:00515612 | Liver | HCC | positive regulation of mitochondrial calcium ion concentration | 10/7958 | 11/18723 | 1.30e-03 | 7.01e-03 | 10 |
GO:000683918 | Oral cavity | OSCC | mitochondrial transport | 162/7305 | 254/18723 | 8.96e-16 | 6.52e-14 | 162 |
GO:00515615 | Oral cavity | OSCC | positive regulation of mitochondrial calcium ion concentration | 10/7305 | 11/18723 | 5.78e-04 | 3.30e-03 | 10 |
GO:199054218 | Oral cavity | OSCC | mitochondrial transmembrane transport | 56/7305 | 102/18723 | 8.06e-04 | 4.32e-03 | 56 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MICU2 | SNV | Missense_Mutation | novel | c.1111N>G | p.Phe371Val | p.F371V | Q8IYU8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MICU2 | SNV | Missense_Mutation | c.271N>G | p.Met91Val | p.M91V | Q8IYU8 | protein_coding | tolerated(0.12) | benign(0.041) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | |
MICU2 | SNV | Missense_Mutation | rs191372140 | c.709N>T | p.Arg237Cys | p.R237C | Q8IYU8 | protein_coding | deleterious(0.04) | benign(0) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MICU2 | SNV | Missense_Mutation | c.169N>C | p.Ser57Arg | p.S57R | Q8IYU8 | protein_coding | tolerated(0.44) | benign(0.003) | TCGA-QL-A97D-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MICU2 | SNV | Missense_Mutation | c.451N>T | p.Asp151Tyr | p.D151Y | Q8IYU8 | protein_coding | deleterious(0) | possibly_damaging(0.687) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
MICU2 | insertion | Frame_Shift_Ins | novel | c.583_584insA | p.Arg195LysfsTer5 | p.R195Kfs*5 | Q8IYU8 | protein_coding | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | ||
MICU2 | SNV | Missense_Mutation | novel | c.1031N>T | p.Pro344Leu | p.P344L | Q8IYU8 | protein_coding | deleterious(0) | possibly_damaging(0.873) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MICU2 | SNV | Missense_Mutation | novel | c.742C>A | p.His248Asn | p.H248N | Q8IYU8 | protein_coding | tolerated(0.91) | benign(0.169) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MICU2 | SNV | Missense_Mutation | rs191372140 | c.709N>T | p.Arg237Cys | p.R237C | Q8IYU8 | protein_coding | deleterious(0.04) | benign(0) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
MICU2 | SNV | Missense_Mutation | novel | c.826N>G | p.Ser276Gly | p.S276G | Q8IYU8 | protein_coding | tolerated(0.07) | benign(0.006) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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