Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/MICU1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/MICU1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/MICU1_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/MICU1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/MICU1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/MICU1_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/MICU1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/MICU1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006839 | Colorectum | AD | mitochondrial transport | 102/3918 | 254/18723 | 1.87e-12 | 3.08e-10 | 102 |
GO:1990542 | Colorectum | AD | mitochondrial transmembrane transport | 47/3918 | 102/18723 | 1.09e-08 | 6.52e-07 | 47 |
GO:0062197 | Colorectum | AD | cellular response to chemical stress | 109/3918 | 337/18723 | 5.33e-07 | 1.95e-05 | 109 |
GO:0051560 | Colorectum | AD | mitochondrial calcium ion homeostasis | 13/3918 | 26/18723 | 9.41e-04 | 8.92e-03 | 13 |
GO:0036444 | Colorectum | AD | calcium import into the mitochondrion | 8/3918 | 14/18723 | 3.23e-03 | 2.38e-02 | 8 |
GO:0006851 | Colorectum | AD | mitochondrial calcium ion transmembrane transport | 10/3918 | 20/18723 | 3.67e-03 | 2.60e-02 | 10 |
GO:0071472 | Colorectum | AD | cellular response to salt stress | 7/3918 | 12/18723 | 5.09e-03 | 3.38e-02 | 7 |
GO:00068391 | Colorectum | SER | mitochondrial transport | 87/2897 | 254/18723 | 7.91e-14 | 3.03e-11 | 87 |
GO:19905421 | Colorectum | SER | mitochondrial transmembrane transport | 42/2897 | 102/18723 | 3.65e-10 | 4.77e-08 | 42 |
GO:00621971 | Colorectum | SER | cellular response to chemical stress | 87/2897 | 337/18723 | 5.33e-07 | 2.59e-05 | 87 |
GO:00068511 | Colorectum | SER | mitochondrial calcium ion transmembrane transport | 10/2897 | 20/18723 | 3.20e-04 | 5.15e-03 | 10 |
GO:00364441 | Colorectum | SER | calcium import into the mitochondrion | 8/2897 | 14/18723 | 4.06e-04 | 6.07e-03 | 8 |
GO:00515601 | Colorectum | SER | mitochondrial calcium ion homeostasis | 11/2897 | 26/18723 | 9.60e-04 | 1.15e-02 | 11 |
GO:0051561 | Colorectum | SER | positive regulation of mitochondrial calcium ion concentration | 6/2897 | 11/18723 | 3.12e-03 | 2.70e-02 | 6 |
GO:0006970 | Colorectum | SER | response to osmotic stress | 23/2897 | 84/18723 | 3.61e-03 | 3.03e-02 | 23 |
GO:00714721 | Colorectum | SER | cellular response to salt stress | 6/2897 | 12/18723 | 5.42e-03 | 4.03e-02 | 6 |
GO:00068392 | Colorectum | MSS | mitochondrial transport | 93/3467 | 254/18723 | 6.14e-12 | 9.82e-10 | 93 |
GO:00621972 | Colorectum | MSS | cellular response to chemical stress | 102/3467 | 337/18723 | 9.73e-08 | 4.71e-06 | 102 |
GO:19905422 | Colorectum | MSS | mitochondrial transmembrane transport | 41/3467 | 102/18723 | 2.70e-07 | 1.11e-05 | 41 |
GO:00515602 | Colorectum | MSS | mitochondrial calcium ion homeostasis | 12/3467 | 26/18723 | 1.16e-03 | 1.12e-02 | 12 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MICU1 | SNV | Missense_Mutation | novel | c.395N>A | p.Ala132Asp | p.A132D | Q9BPX6 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD |
MICU1 | SNV | Missense_Mutation | novel | c.218N>C | p.Lys73Thr | p.K73T | Q9BPX6 | protein_coding | tolerated_low_confidence(0.12) | benign(0.001) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MICU1 | SNV | Missense_Mutation | rs754124319 | c.523C>T | p.Arg175Cys | p.R175C | Q9BPX6 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD |
MICU1 | SNV | Missense_Mutation | | c.232G>C | p.Asp78His | p.D78H | Q9BPX6 | protein_coding | deleterious(0.03) | benign(0) | TCGA-EW-A6SD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | tch | SD |
MICU1 | SNV | Missense_Mutation | novel | c.23N>T | p.Ser8Phe | p.S8F | Q9BPX6 | protein_coding | deleterious_low_confidence(0.03) | benign(0.365) | TCGA-PE-A5DC-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
MICU1 | deletion | Frame_Shift_Del | novel | c.721delN | p.Glu241LysfsTer47 | p.E241Kfs*47 | Q9BPX6 | protein_coding | | | TCGA-BH-A1EN-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MICU1 | SNV | Missense_Mutation | rs367648335 | c.775C>T | p.Arg259Cys | p.R259C | Q9BPX6 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-VS-A9UI-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
MICU1 | SNV | Missense_Mutation | rs752729268 | c.524N>A | p.Arg175His | p.R175H | Q9BPX6 | protein_coding | deleterious(0.04) | benign(0.072) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
MICU1 | SNV | Missense_Mutation | | c.451N>T | p.Asp151Tyr | p.D151Y | Q9BPX6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AZ-4616-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | PD |
MICU1 | SNV | Missense_Mutation | rs750157034 | c.776N>A | p.Arg259His | p.R259H | Q9BPX6 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |