![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: MFSD14C |
Gene summary for MFSD14C |
![]() |
Gene information | Species | Human | Gene symbol | MFSD14C | Gene ID | 84278 |
Gene name | major facilitator superfamily domain containing 14C | |
Gene Alias | HIATL2 | |
Cytomap | 9q22.33 | |
Gene Type | pseudo | GO ID | GO:0006810 | UniProtAcc | NA |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84278 | MFSD14C | P15T-E | Human | Esophagus | ESCC | 2.41e-05 | 1.10e-01 | 0.1149 |
84278 | MFSD14C | P16T-E | Human | Esophagus | ESCC | 3.16e-06 | 1.35e-01 | 0.1153 |
84278 | MFSD14C | P17T-E | Human | Esophagus | ESCC | 1.14e-02 | 1.94e-01 | 0.1278 |
84278 | MFSD14C | P20T-E | Human | Esophagus | ESCC | 7.60e-05 | 1.84e-01 | 0.1124 |
84278 | MFSD14C | P21T-E | Human | Esophagus | ESCC | 3.84e-18 | 3.94e-01 | 0.1617 |
84278 | MFSD14C | P22T-E | Human | Esophagus | ESCC | 2.32e-12 | 2.37e-01 | 0.1236 |
84278 | MFSD14C | P23T-E | Human | Esophagus | ESCC | 1.01e-04 | 1.51e-01 | 0.108 |
84278 | MFSD14C | P24T-E | Human | Esophagus | ESCC | 8.13e-07 | 1.20e-01 | 0.1287 |
84278 | MFSD14C | P26T-E | Human | Esophagus | ESCC | 6.36e-09 | 1.37e-01 | 0.1276 |
84278 | MFSD14C | P27T-E | Human | Esophagus | ESCC | 2.66e-07 | 1.58e-01 | 0.1055 |
84278 | MFSD14C | P28T-E | Human | Esophagus | ESCC | 1.29e-16 | 2.76e-01 | 0.1149 |
84278 | MFSD14C | P30T-E | Human | Esophagus | ESCC | 3.18e-17 | 5.36e-01 | 0.137 |
84278 | MFSD14C | P31T-E | Human | Esophagus | ESCC | 6.12e-07 | 1.64e-01 | 0.1251 |
84278 | MFSD14C | P32T-E | Human | Esophagus | ESCC | 3.27e-09 | 1.76e-01 | 0.1666 |
84278 | MFSD14C | P36T-E | Human | Esophagus | ESCC | 1.22e-22 | 6.20e-01 | 0.1187 |
84278 | MFSD14C | P37T-E | Human | Esophagus | ESCC | 1.14e-05 | 1.52e-01 | 0.1371 |
84278 | MFSD14C | P39T-E | Human | Esophagus | ESCC | 5.00e-14 | 2.82e-01 | 0.0894 |
84278 | MFSD14C | P40T-E | Human | Esophagus | ESCC | 1.97e-09 | 2.96e-01 | 0.109 |
84278 | MFSD14C | P42T-E | Human | Esophagus | ESCC | 5.88e-05 | 1.39e-01 | 0.1175 |
84278 | MFSD14C | P44T-E | Human | Esophagus | ESCC | 4.18e-04 | 1.35e-01 | 0.1096 |
Page: 1 2 3 4 5 6 7 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MFSD14C | SNV | Missense_Mutation | c.226N>G | p.Gln76Glu | p.Q76E | protein_coding | tolerated(0.5) | benign(0.011) | TCGA-D8-A1J9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
MFSD14C | SNV | Missense_Mutation | novel | c.133G>T | p.Val45Leu | p.V45L | protein_coding | tolerated(0.07) | possibly_damaging(0.517) | TCGA-D8-A1X8-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adrimicin+cyclophosphamide | SD | |
MFSD14C | SNV | Missense_Mutation | c.269G>A | p.Gly90Asp | p.G90D | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MFSD14C | SNV | Missense_Mutation | novel | c.216A>C | p.Glu72Asp | p.E72D | protein_coding | tolerated(0.22) | benign(0.099) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MFSD14C | SNV | Missense_Mutation | novel | c.290N>T | p.Ala97Val | p.A97V | protein_coding | deleterious(0) | probably_damaging(0.97) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MFSD14C | SNV | Missense_Mutation | c.208N>A | p.Leu70Ile | p.L70I | protein_coding | deleterious(0.03) | possibly_damaging(0.883) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | ||
MFSD14C | SNV | Missense_Mutation | novel | c.367C>T | p.Pro123Ser | p.P123S | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-05-4420-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MFSD14C | SNV | Missense_Mutation | novel | c.321G>T | p.Trp107Cys | p.W107C | protein_coding | deleterious(0.02) | benign(0.16) | TCGA-55-A4DG-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MFSD14C | SNV | Missense_Mutation | novel | c.289N>A | p.Ala97Thr | p.A97T | protein_coding | tolerated(0.09) | probably_damaging(0.923) | TCGA-NK-A5CR-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |