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Gene: METTL26 |
Gene summary for METTL26 |
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Gene information | Species | Human | Gene symbol | METTL26 | Gene ID | 84326 |
Gene name | methyltransferase like 26 | |
Gene Alias | C16orf13 | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q96S19 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84326 | METTL26 | P52T-E | Human | Esophagus | ESCC | 1.78e-03 | -1.95e-01 | 0.1555 |
84326 | METTL26 | P57T-E | Human | Esophagus | ESCC | 1.78e-03 | -1.95e-01 | 0.0926 |
84326 | METTL26 | P62T-E | Human | Esophagus | ESCC | 4.72e-02 | -1.95e-01 | 0.1302 |
84326 | METTL26 | P75T-E | Human | Esophagus | ESCC | 1.66e-02 | -1.95e-01 | 0.1125 |
84326 | METTL26 | P76T-E | Human | Esophagus | ESCC | 1.78e-03 | -1.95e-01 | 0.1207 |
84326 | METTL26 | P79T-E | Human | Esophagus | ESCC | 1.78e-03 | -1.95e-01 | 0.1154 |
84326 | METTL26 | P127T-E | Human | Esophagus | ESCC | 3.72e-02 | -1.95e-01 | 0.0826 |
84326 | METTL26 | P130T-E | Human | Esophagus | ESCC | 3.75e-03 | -1.95e-01 | 0.1676 |
84326 | METTL26 | HCC1 | Human | Liver | HCC | 5.46e-14 | 4.65e+00 | 0.5336 |
84326 | METTL26 | HCC2 | Human | Liver | HCC | 2.96e-18 | 4.68e+00 | 0.5341 |
84326 | METTL26 | HCC5 | Human | Liver | HCC | 2.12e-06 | 2.90e+00 | 0.4932 |
84326 | METTL26 | S014 | Human | Liver | HCC | 3.17e-66 | 2.11e+00 | 0.2254 |
84326 | METTL26 | S015 | Human | Liver | HCC | 1.62e-50 | 2.00e+00 | 0.2375 |
84326 | METTL26 | S016 | Human | Liver | HCC | 8.34e-63 | 2.00e+00 | 0.2243 |
84326 | METTL26 | S027 | Human | Liver | HCC | 1.39e-26 | 2.08e+00 | 0.2446 |
84326 | METTL26 | S028 | Human | Liver | HCC | 6.66e-55 | 2.24e+00 | 0.2503 |
84326 | METTL26 | S029 | Human | Liver | HCC | 1.38e-49 | 2.37e+00 | 0.2581 |
84326 | METTL26 | male-WTA | Human | Thyroid | PTC | 9.34e-30 | 3.26e-01 | 0.1037 |
84326 | METTL26 | PTC01 | Human | Thyroid | PTC | 2.48e-15 | 4.24e-01 | 0.1899 |
84326 | METTL26 | PTC04 | Human | Thyroid | PTC | 2.09e-13 | 3.18e-01 | 0.1927 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
METTL26 | SNV | Missense_Mutation | novel | c.416A>G | p.Tyr139Cys | p.Y139C | Q96S19 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-WT-AB41-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
METTL26 | SNV | Missense_Mutation | c.532N>G | p.Leu178Val | p.L178V | Q96S19 | protein_coding | deleterious_low_confidence(0.01) | benign(0.031) | TCGA-MU-A51Y-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
METTL26 | SNV | Missense_Mutation | rs142689363 | c.512N>A | p.Ser171Asn | p.S171N | Q96S19 | protein_coding | tolerated_low_confidence(0.16) | possibly_damaging(0.474) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
METTL26 | SNV | Missense_Mutation | novel | c.305T>C | p.Leu102Pro | p.L102P | Q96S19 | protein_coding | deleterious(0.03) | probably_damaging(0.946) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
METTL26 | SNV | Missense_Mutation | novel | c.269G>A | p.Gly90Asp | p.G90D | Q96S19 | protein_coding | tolerated(0.87) | benign(0) | TCGA-D1-A15X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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