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Gene: MCTS1 |
Gene summary for MCTS1 |
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Gene information | Species | Human | Gene symbol | MCTS1 | Gene ID | 28985 |
Gene name | MCTS1 re-initiation and release factor | |
Gene Alias | MCT-1 | |
Cytomap | Xq24 | |
Gene Type | protein-coding | GO ID | GO:0001731 | UniProtAcc | Q9ULC4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
28985 | MCTS1 | P107T-E | Human | Esophagus | ESCC | 1.83e-61 | 1.41e+00 | 0.171 |
28985 | MCTS1 | P126T-E | Human | Esophagus | ESCC | 1.08e-09 | 1.04e+00 | 0.1125 |
28985 | MCTS1 | P127T-E | Human | Esophagus | ESCC | 1.06e-24 | 3.80e-01 | 0.0826 |
28985 | MCTS1 | P128T-E | Human | Esophagus | ESCC | 3.81e-22 | 7.30e-01 | 0.1241 |
28985 | MCTS1 | P130T-E | Human | Esophagus | ESCC | 4.87e-62 | 1.41e+00 | 0.1676 |
28985 | MCTS1 | HCC1_Meng | Human | Liver | HCC | 5.13e-89 | 4.17e-01 | 0.0246 |
28985 | MCTS1 | HCC2_Meng | Human | Liver | HCC | 4.49e-50 | 4.28e-01 | 0.0107 |
28985 | MCTS1 | cirrhotic1 | Human | Liver | Cirrhotic | 1.31e-11 | 1.30e-01 | 0.0202 |
28985 | MCTS1 | cirrhotic2 | Human | Liver | Cirrhotic | 3.91e-10 | 1.75e-01 | 0.0201 |
28985 | MCTS1 | cirrhotic3 | Human | Liver | Cirrhotic | 3.89e-08 | 2.23e-01 | 0.0215 |
28985 | MCTS1 | HCC1 | Human | Liver | HCC | 3.90e-19 | 4.42e+00 | 0.5336 |
28985 | MCTS1 | HCC2 | Human | Liver | HCC | 1.37e-25 | 3.54e+00 | 0.5341 |
28985 | MCTS1 | HCC5 | Human | Liver | HCC | 2.49e-32 | 2.51e+00 | 0.4932 |
28985 | MCTS1 | Pt13.a | Human | Liver | HCC | 3.36e-02 | 1.95e-01 | 0.021 |
28985 | MCTS1 | Pt13.b | Human | Liver | HCC | 8.35e-19 | 3.01e-01 | 0.0251 |
28985 | MCTS1 | Pt14.a | Human | Liver | HCC | 3.65e-02 | 2.92e-01 | 0.0169 |
28985 | MCTS1 | Pt14.b | Human | Liver | HCC | 2.27e-04 | 3.04e-01 | 0.018 |
28985 | MCTS1 | Pt14.d | Human | Liver | HCC | 1.24e-05 | 1.97e-01 | 0.0143 |
28985 | MCTS1 | S014 | Human | Liver | HCC | 9.86e-18 | 7.81e-01 | 0.2254 |
28985 | MCTS1 | S015 | Human | Liver | HCC | 4.16e-16 | 1.11e+00 | 0.2375 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000218127 | Esophagus | HGIN | cytoplasmic translation | 108/2587 | 148/18723 | 1.70e-60 | 1.02e-56 | 108 |
GO:002261327 | Esophagus | HGIN | ribonucleoprotein complex biogenesis | 158/2587 | 463/18723 | 2.61e-29 | 5.23e-26 | 158 |
GO:007182627 | Esophagus | HGIN | ribonucleoprotein complex subunit organization | 84/2587 | 227/18723 | 1.34e-18 | 5.37e-16 | 84 |
GO:002261827 | Esophagus | HGIN | ribonucleoprotein complex assembly | 82/2587 | 220/18723 | 2.07e-18 | 7.36e-16 | 82 |
GO:000641320 | Esophagus | HGIN | translational initiation | 55/2587 | 118/18723 | 7.33e-18 | 2.31e-15 | 55 |
GO:001603227 | Esophagus | HGIN | viral process | 118/2587 | 415/18723 | 3.01e-15 | 6.22e-13 | 118 |
GO:000218320 | Esophagus | HGIN | cytoplasmic translational initiation | 19/2587 | 34/18723 | 1.01e-08 | 6.44e-07 | 19 |
GO:002241120 | Esophagus | HGIN | cellular component disassembly | 102/2587 | 443/18723 | 8.31e-08 | 4.33e-06 | 102 |
GO:19030089 | Esophagus | HGIN | organelle disassembly | 36/2587 | 114/18723 | 8.60e-07 | 3.58e-05 | 36 |
GO:001908016 | Esophagus | HGIN | viral gene expression | 28/2587 | 94/18723 | 4.52e-05 | 1.09e-03 | 28 |
GO:001908115 | Esophagus | HGIN | viral translation | 8/2587 | 16/18723 | 6.00e-04 | 8.41e-03 | 8 |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0002181111 | Esophagus | ESCC | cytoplasmic translation | 135/8552 | 148/18723 | 4.17e-32 | 2.65e-29 | 135 |
GO:0016032111 | Esophagus | ESCC | viral process | 301/8552 | 415/18723 | 3.34e-29 | 1.32e-26 | 301 |
GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
GO:0006413110 | Esophagus | ESCC | translational initiation | 100/8552 | 118/18723 | 1.16e-18 | 1.25e-16 | 100 |
GO:0071826111 | Esophagus | ESCC | ribonucleoprotein complex subunit organization | 166/8552 | 227/18723 | 2.94e-17 | 2.42e-15 | 166 |
GO:0022618111 | Esophagus | ESCC | ribonucleoprotein complex assembly | 159/8552 | 220/18723 | 8.19e-16 | 5.71e-14 | 159 |
GO:001908017 | Esophagus | ESCC | viral gene expression | 80/8552 | 94/18723 | 2.04e-15 | 1.28e-13 | 80 |
GO:190300816 | Esophagus | ESCC | organelle disassembly | 89/8552 | 114/18723 | 1.36e-12 | 5.80e-11 | 89 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MCTS1 | SNV | Missense_Mutation | rs750185102 | c.5G>A | p.Gly2Asp | p.G2D | Q9ULC4 | protein_coding | deleterious_low_confidence(0) | benign(0.07) | TCGA-A1-A0SJ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MCTS1 | SNV | Missense_Mutation | c.81G>T | p.Lys27Asn | p.K27N | Q9ULC4 | protein_coding | deleterious(0) | probably_damaging(0.944) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MCTS1 | SNV | Missense_Mutation | c.433N>C | p.Cys145Arg | p.C145R | Q9ULC4 | protein_coding | deleterious(0) | benign(0.239) | TCGA-A6-2684-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
MCTS1 | SNV | Missense_Mutation | c.491N>A | p.Gly164Asp | p.G164D | Q9ULC4 | protein_coding | deleterious(0.02) | benign(0.226) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
MCTS1 | SNV | Missense_Mutation | c.27A>C | p.Lys9Asn | p.K9N | Q9ULC4 | protein_coding | deleterious(0.03) | benign(0.267) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
MCTS1 | SNV | Missense_Mutation | novel | c.96N>T | p.Glu32Asp | p.E32D | Q9ULC4 | protein_coding | tolerated(0.28) | benign(0) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MCTS1 | SNV | Missense_Mutation | c.224G>A | p.Arg75Lys | p.R75K | Q9ULC4 | protein_coding | tolerated(0.44) | benign(0.203) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MCTS1 | SNV | Missense_Mutation | novel | c.141N>T | p.Lys47Asn | p.K47N | Q9ULC4 | protein_coding | deleterious(0) | possibly_damaging(0.847) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MCTS1 | SNV | Missense_Mutation | c.314T>C | p.Phe105Ser | p.F105S | Q9ULC4 | protein_coding | deleterious(0.03) | possibly_damaging(0.455) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MCTS1 | SNV | Missense_Mutation | c.398N>C | p.Val133Ala | p.V133A | Q9ULC4 | protein_coding | deleterious(0.01) | probably_damaging(0.956) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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