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Gene: MARVELD1 |
Gene summary for MARVELD1 |
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Gene information | Species | Human | Gene symbol | MARVELD1 | Gene ID | 83742 |
Gene name | MARVEL domain containing 1 | |
Gene Alias | GB14 | |
Cytomap | 10q24.2 | |
Gene Type | protein-coding | GO ID | GO:0007049 | UniProtAcc | Q9BSK0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83742 | MARVELD1 | C08 | Human | Oral cavity | OSCC | 3.40e-10 | 3.23e-01 | 0.1919 |
83742 | MARVELD1 | LP15 | Human | Oral cavity | LP | 2.68e-05 | 1.18e+00 | 0.2174 |
83742 | MARVELD1 | LP17 | Human | Oral cavity | LP | 3.23e-02 | 5.14e-01 | 0.2349 |
83742 | MARVELD1 | SYSMH1 | Human | Oral cavity | OSCC | 7.55e-06 | 2.48e-01 | 0.1127 |
83742 | MARVELD1 | SYSMH2 | Human | Oral cavity | OSCC | 8.38e-17 | 7.09e-01 | 0.2326 |
83742 | MARVELD1 | SYSMH3 | Human | Oral cavity | OSCC | 1.04e-25 | 7.97e-01 | 0.2442 |
83742 | MARVELD1 | SYSMH5 | Human | Oral cavity | OSCC | 2.80e-06 | 3.18e-01 | 0.0647 |
83742 | MARVELD1 | SYSMH6 | Human | Oral cavity | OSCC | 2.76e-04 | 1.63e-01 | 0.1275 |
83742 | MARVELD1 | P1_cSCC | Human | Skin | cSCC | 4.39e-08 | 4.49e-01 | 0.0292 |
83742 | MARVELD1 | P2_cSCC | Human | Skin | cSCC | 2.45e-10 | 2.95e-01 | -0.024 |
83742 | MARVELD1 | P4_cSCC | Human | Skin | cSCC | 3.15e-03 | 2.35e-01 | -0.00290000000000005 |
83742 | MARVELD1 | P10_cSCC | Human | Skin | cSCC | 2.90e-18 | 6.03e-01 | 0.1017 |
83742 | MARVELD1 | male-WTA | Human | Thyroid | PTC | 2.71e-09 | 1.37e-01 | 0.1037 |
83742 | MARVELD1 | PTC06 | Human | Thyroid | PTC | 1.21e-02 | 1.60e-01 | 0.2057 |
83742 | MARVELD1 | PTC07 | Human | Thyroid | PTC | 5.85e-06 | 1.01e-01 | 0.2044 |
83742 | MARVELD1 | ATC09 | Human | Thyroid | ATC | 5.47e-05 | 2.09e-01 | 0.2871 |
83742 | MARVELD1 | ATC11 | Human | Thyroid | ATC | 5.35e-04 | 4.31e-01 | 0.3386 |
83742 | MARVELD1 | ATC12 | Human | Thyroid | ATC | 3.80e-36 | 6.66e-01 | 0.34 |
83742 | MARVELD1 | ATC13 | Human | Thyroid | ATC | 6.03e-40 | 6.92e-01 | 0.34 |
83742 | MARVELD1 | ATC1 | Human | Thyroid | ATC | 4.95e-05 | 2.44e-01 | 0.2878 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00425524 | Esophagus | ESCC | myelination | 85/8552 | 134/18723 | 2.51e-05 | 2.13e-04 | 85 |
GO:00072724 | Esophagus | ESCC | ensheathment of neurons | 86/8552 | 136/18723 | 2.68e-05 | 2.24e-04 | 86 |
GO:00083664 | Esophagus | ESCC | axon ensheathment | 86/8552 | 136/18723 | 2.68e-05 | 2.24e-04 | 86 |
GO:00072723 | Oral cavity | OSCC | ensheathment of neurons | 72/7305 | 136/18723 | 6.59e-04 | 3.70e-03 | 72 |
GO:00083663 | Oral cavity | OSCC | axon ensheathment | 72/7305 | 136/18723 | 6.59e-04 | 3.70e-03 | 72 |
GO:00425523 | Oral cavity | OSCC | myelination | 71/7305 | 134/18723 | 6.93e-04 | 3.86e-03 | 71 |
GO:004255221 | Skin | cSCC | myelination | 51/4864 | 134/18723 | 1.37e-03 | 8.70e-03 | 51 |
GO:000727221 | Skin | cSCC | ensheathment of neurons | 51/4864 | 136/18723 | 1.99e-03 | 1.19e-02 | 51 |
GO:000836621 | Skin | cSCC | axon ensheathment | 51/4864 | 136/18723 | 1.99e-03 | 1.19e-02 | 51 |
GO:00425526 | Thyroid | ATC | myelination | 62/6293 | 134/18723 | 1.54e-03 | 7.84e-03 | 62 |
GO:00072726 | Thyroid | ATC | ensheathment of neurons | 62/6293 | 136/18723 | 2.39e-03 | 1.11e-02 | 62 |
GO:00083666 | Thyroid | ATC | axon ensheathment | 62/6293 | 136/18723 | 2.39e-03 | 1.11e-02 | 62 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MARVELD1 | SNV | Missense_Mutation | novel | c.223N>T | p.Leu75Phe | p.L75F | Q9BSK0 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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