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Gene: MAFF |
Gene summary for MAFF |
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Gene information | Species | Human | Gene symbol | MAFF | Gene ID | 23764 |
Gene name | MAF bZIP transcription factor F | |
Gene Alias | U-MAF | |
Cytomap | 22q13.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9ULX9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23764 | MAFF | P15T-E | Human | Esophagus | ESCC | 1.33e-14 | 8.14e-01 | 0.1149 |
23764 | MAFF | P16T-E | Human | Esophagus | ESCC | 9.70e-10 | 2.85e-01 | 0.1153 |
23764 | MAFF | P19T-E | Human | Esophagus | ESCC | 1.33e-02 | 1.98e-01 | 0.1662 |
23764 | MAFF | P21T-E | Human | Esophagus | ESCC | 3.71e-26 | 8.40e-01 | 0.1617 |
23764 | MAFF | P22T-E | Human | Esophagus | ESCC | 4.38e-05 | 7.42e-02 | 0.1236 |
23764 | MAFF | P23T-E | Human | Esophagus | ESCC | 1.86e-43 | 2.21e+00 | 0.108 |
23764 | MAFF | P24T-E | Human | Esophagus | ESCC | 1.07e-08 | 3.01e-01 | 0.1287 |
23764 | MAFF | P26T-E | Human | Esophagus | ESCC | 3.32e-41 | 9.93e-01 | 0.1276 |
23764 | MAFF | P27T-E | Human | Esophagus | ESCC | 4.05e-22 | 7.94e-01 | 0.1055 |
23764 | MAFF | P28T-E | Human | Esophagus | ESCC | 1.16e-29 | 8.92e-01 | 0.1149 |
23764 | MAFF | P30T-E | Human | Esophagus | ESCC | 2.11e-27 | 1.80e+00 | 0.137 |
23764 | MAFF | P31T-E | Human | Esophagus | ESCC | 3.51e-25 | 7.27e-01 | 0.1251 |
23764 | MAFF | P32T-E | Human | Esophagus | ESCC | 1.40e-06 | 2.38e-01 | 0.1666 |
23764 | MAFF | P36T-E | Human | Esophagus | ESCC | 2.26e-10 | 9.63e-01 | 0.1187 |
23764 | MAFF | P37T-E | Human | Esophagus | ESCC | 1.20e-02 | 3.34e-01 | 0.1371 |
23764 | MAFF | P39T-E | Human | Esophagus | ESCC | 4.79e-32 | 1.20e+00 | 0.0894 |
23764 | MAFF | P40T-E | Human | Esophagus | ESCC | 4.23e-10 | 1.07e+00 | 0.109 |
23764 | MAFF | P42T-E | Human | Esophagus | ESCC | 9.08e-17 | 1.09e+00 | 0.1175 |
23764 | MAFF | P47T-E | Human | Esophagus | ESCC | 2.96e-27 | 8.49e-01 | 0.1067 |
23764 | MAFF | P48T-E | Human | Esophagus | ESCC | 4.58e-21 | 7.77e-01 | 0.0959 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00447063 | Breast | Precancer | multi-multicellular organism process | 31/1080 | 220/18723 | 3.73e-06 | 1.19e-04 | 31 |
GO:00085445 | Breast | Precancer | epidermis development | 35/1080 | 324/18723 | 2.71e-04 | 3.96e-03 | 35 |
GO:00099136 | Breast | Precancer | epidermal cell differentiation | 23/1080 | 202/18723 | 1.43e-03 | 1.50e-02 | 23 |
GO:0035914 | Breast | Precancer | skeletal muscle cell differentiation | 11/1080 | 67/18723 | 1.47e-03 | 1.52e-02 | 11 |
GO:00017017 | Breast | Precancer | in utero embryonic development | 35/1080 | 367/18723 | 2.47e-03 | 2.27e-02 | 35 |
GO:00605374 | Breast | Precancer | muscle tissue development | 37/1080 | 403/18723 | 3.60e-03 | 2.98e-02 | 37 |
GO:00147063 | Breast | Precancer | striated muscle tissue development | 35/1080 | 384/18723 | 5.10e-03 | 3.83e-02 | 35 |
GO:00447061 | Breast | IDC | multi-multicellular organism process | 41/1434 | 220/18723 | 8.58e-08 | 5.19e-06 | 41 |
GO:006053711 | Breast | IDC | muscle tissue development | 50/1434 | 403/18723 | 4.91e-04 | 6.45e-03 | 50 |
GO:000854412 | Breast | IDC | epidermis development | 41/1434 | 324/18723 | 1.03e-03 | 1.14e-02 | 41 |
GO:00359141 | Breast | IDC | skeletal muscle cell differentiation | 13/1434 | 67/18723 | 1.52e-03 | 1.52e-02 | 13 |
GO:000991312 | Breast | IDC | epidermal cell differentiation | 28/1434 | 202/18723 | 1.62e-03 | 1.60e-02 | 28 |
GO:00147061 | Breast | IDC | striated muscle tissue development | 46/1434 | 384/18723 | 1.67e-03 | 1.63e-02 | 46 |
GO:000170113 | Breast | IDC | in utero embryonic development | 42/1434 | 367/18723 | 5.85e-03 | 4.24e-02 | 42 |
GO:00075172 | Breast | IDC | muscle organ development | 38/1434 | 327/18723 | 6.63e-03 | 4.62e-02 | 38 |
GO:00447062 | Breast | DCIS | multi-multicellular organism process | 39/1390 | 220/18723 | 3.05e-07 | 1.46e-05 | 39 |
GO:006053721 | Breast | DCIS | muscle tissue development | 50/1390 | 403/18723 | 2.39e-04 | 3.74e-03 | 50 |
GO:00147062 | Breast | DCIS | striated muscle tissue development | 46/1390 | 384/18723 | 8.88e-04 | 1.01e-02 | 46 |
GO:000854422 | Breast | DCIS | epidermis development | 40/1390 | 324/18723 | 1.05e-03 | 1.16e-02 | 40 |
GO:00359142 | Breast | DCIS | skeletal muscle cell differentiation | 13/1390 | 67/18723 | 1.14e-03 | 1.22e-02 | 13 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
MAFF | LC | Lung | AIS | PLA2G6,GPR183,AC009690.2, etc. | 2.91e-01 | ![]() |
MAFF | STM | Oral cavity | EOLP | ELF3,ITPKC,CSRNP1, etc. | 8.08e-01 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAFF | SNV | Missense_Mutation | novel | c.300G>A | p.Met100Ile | p.M100I | Q9ULX9 | protein_coding | deleterious(0.03) | benign(0.085) | TCGA-ZJ-AAXA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
MAFF | SNV | Missense_Mutation | c.125N>A | p.Arg42His | p.R42H | Q9ULX9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MAFF | SNV | Missense_Mutation | novel | c.284G>A | p.Arg95His | p.R95H | Q9ULX9 | protein_coding | deleterious(0.03) | possibly_damaging(0.879) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
MAFF | SNV | Missense_Mutation | novel | c.88N>G | p.Met30Val | p.M30V | Q9ULX9 | protein_coding | tolerated(1) | benign(0.027) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MAFF | SNV | Missense_Mutation | c.208G>A | p.Val70Met | p.V70M | Q9ULX9 | protein_coding | deleterious(0.04) | probably_damaging(0.974) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
MAFF | SNV | Missense_Mutation | novel | c.103N>T | p.Arg35Cys | p.R35C | Q9ULX9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
MAFF | SNV | Missense_Mutation | rs377667070 | c.19N>C | p.Ser7Pro | p.S7P | Q9ULX9 | protein_coding | tolerated(0.25) | benign(0.003) | TCGA-J9-A52E-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Hormone Therapy | zoladex | SD |
MAFF | SNV | Missense_Mutation | c.208N>A | p.Val70Met | p.V70M | Q9ULX9 | protein_coding | deleterious(0.04) | probably_damaging(0.974) | TCGA-BR-8372-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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