![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: LCLAT1 |
Gene summary for LCLAT1 |
![]() |
Gene information | Species | Human | Gene symbol | LCLAT1 | Gene ID | 253558 |
Gene name | lysocardiolipin acyltransferase 1 | |
Gene Alias | 1AGPAT8 | |
Cytomap | 2p23.1 | |
Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | Q6UWP7 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
253558 | LCLAT1 | P24T-E | Human | Esophagus | ESCC | 8.42e-16 | 1.65e-01 | 0.1287 |
253558 | LCLAT1 | P26T-E | Human | Esophagus | ESCC | 9.07e-25 | 5.05e-01 | 0.1276 |
253558 | LCLAT1 | P27T-E | Human | Esophagus | ESCC | 4.75e-22 | 3.43e-01 | 0.1055 |
253558 | LCLAT1 | P28T-E | Human | Esophagus | ESCC | 5.84e-21 | 3.41e-01 | 0.1149 |
253558 | LCLAT1 | P30T-E | Human | Esophagus | ESCC | 9.20e-05 | 1.75e-01 | 0.137 |
253558 | LCLAT1 | P31T-E | Human | Esophagus | ESCC | 8.44e-13 | 1.98e-01 | 0.1251 |
253558 | LCLAT1 | P32T-E | Human | Esophagus | ESCC | 8.67e-19 | 3.64e-01 | 0.1666 |
253558 | LCLAT1 | P36T-E | Human | Esophagus | ESCC | 3.95e-12 | 2.88e-01 | 0.1187 |
253558 | LCLAT1 | P37T-E | Human | Esophagus | ESCC | 5.65e-18 | 3.47e-01 | 0.1371 |
253558 | LCLAT1 | P39T-E | Human | Esophagus | ESCC | 9.09e-10 | 1.54e-01 | 0.0894 |
253558 | LCLAT1 | P40T-E | Human | Esophagus | ESCC | 6.35e-03 | 1.07e-01 | 0.109 |
253558 | LCLAT1 | P42T-E | Human | Esophagus | ESCC | 2.42e-06 | 1.80e-01 | 0.1175 |
253558 | LCLAT1 | P44T-E | Human | Esophagus | ESCC | 2.09e-04 | 1.76e-01 | 0.1096 |
253558 | LCLAT1 | P47T-E | Human | Esophagus | ESCC | 1.46e-18 | 2.37e-01 | 0.1067 |
253558 | LCLAT1 | P48T-E | Human | Esophagus | ESCC | 2.70e-09 | 2.09e-01 | 0.0959 |
253558 | LCLAT1 | P49T-E | Human | Esophagus | ESCC | 2.95e-08 | 4.21e-01 | 0.1768 |
253558 | LCLAT1 | P52T-E | Human | Esophagus | ESCC | 3.42e-15 | 2.56e-01 | 0.1555 |
253558 | LCLAT1 | P54T-E | Human | Esophagus | ESCC | 1.13e-17 | 3.40e-01 | 0.0975 |
253558 | LCLAT1 | P56T-E | Human | Esophagus | ESCC | 3.89e-06 | 5.53e-01 | 0.1613 |
253558 | LCLAT1 | P57T-E | Human | Esophagus | ESCC | 1.17e-06 | 2.01e-01 | 0.0926 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006650 | Colorectum | AD | glycerophospholipid metabolic process | 83/3918 | 306/18723 | 5.40e-03 | 3.55e-02 | 83 |
GO:0006644 | Colorectum | AD | phospholipid metabolic process | 101/3918 | 383/18723 | 5.80e-03 | 3.67e-02 | 101 |
GO:0045017 | Colorectum | AD | glycerolipid biosynthetic process | 69/3918 | 252/18723 | 8.33e-03 | 4.88e-02 | 69 |
GO:0008654 | Colorectum | FAP | phospholipid biosynthetic process | 54/2622 | 253/18723 | 8.88e-04 | 9.08e-03 | 54 |
GO:00066502 | Colorectum | FAP | glycerophospholipid metabolic process | 62/2622 | 306/18723 | 1.54e-03 | 1.38e-02 | 62 |
GO:00066442 | Colorectum | FAP | phospholipid metabolic process | 74/2622 | 383/18723 | 2.24e-03 | 1.83e-02 | 74 |
GO:0046473 | Colorectum | FAP | phosphatidic acid metabolic process | 12/2622 | 37/18723 | 3.43e-03 | 2.48e-02 | 12 |
GO:0046474 | Colorectum | FAP | glycerophospholipid biosynthetic process | 44/2622 | 211/18723 | 3.98e-03 | 2.76e-02 | 44 |
GO:00450172 | Colorectum | FAP | glycerolipid biosynthetic process | 50/2622 | 252/18723 | 6.32e-03 | 3.95e-02 | 50 |
GO:00086541 | Colorectum | CRC | phospholipid biosynthetic process | 49/2078 | 253/18723 | 7.07e-05 | 1.51e-03 | 49 |
GO:00066503 | Colorectum | CRC | glycerophospholipid metabolic process | 55/2078 | 306/18723 | 2.10e-04 | 3.55e-03 | 55 |
GO:00450173 | Colorectum | CRC | glycerolipid biosynthetic process | 47/2078 | 252/18723 | 2.47e-04 | 4.06e-03 | 47 |
GO:00066443 | Colorectum | CRC | phospholipid metabolic process | 65/2078 | 383/18723 | 3.21e-04 | 4.95e-03 | 65 |
GO:00464741 | Colorectum | CRC | glycerophospholipid biosynthetic process | 40/2078 | 211/18723 | 4.91e-04 | 7.02e-03 | 40 |
GO:00464861 | Colorectum | CRC | glycerolipid metabolic process | 64/2078 | 392/18723 | 1.01e-03 | 1.19e-02 | 64 |
GO:00464731 | Colorectum | CRC | phosphatidic acid metabolic process | 10/2078 | 37/18723 | 5.78e-03 | 4.31e-02 | 10 |
GO:00086544 | Esophagus | ESCC | phospholipid biosynthetic process | 162/8552 | 253/18723 | 2.59e-09 | 5.73e-08 | 162 |
GO:00464744 | Esophagus | ESCC | glycerophospholipid biosynthetic process | 135/8552 | 211/18723 | 5.75e-08 | 1.02e-06 | 135 |
GO:00450175 | Esophagus | ESCC | glycerolipid biosynthetic process | 154/8552 | 252/18723 | 5.20e-07 | 6.96e-06 | 154 |
GO:00066446 | Esophagus | ESCC | phospholipid metabolic process | 218/8552 | 383/18723 | 5.37e-06 | 5.59e-05 | 218 |
Page: 1 2 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00561 | Colorectum | AD | Glycerolipid metabolism | 24/2092 | 63/8465 | 1.25e-02 | 4.54e-02 | 2.90e-02 | 24 |
hsa005611 | Colorectum | AD | Glycerolipid metabolism | 24/2092 | 63/8465 | 1.25e-02 | 4.54e-02 | 2.90e-02 | 24 |
hsa005612 | Colorectum | MSS | Glycerolipid metabolism | 23/1875 | 63/8465 | 6.55e-03 | 2.64e-02 | 1.62e-02 | 23 |
hsa005613 | Colorectum | MSS | Glycerolipid metabolism | 23/1875 | 63/8465 | 6.55e-03 | 2.64e-02 | 1.62e-02 | 23 |
hsa005615 | Liver | HCC | Glycerolipid metabolism | 41/4020 | 63/8465 | 3.59e-03 | 1.12e-02 | 6.22e-03 | 41 |
hsa0056112 | Liver | HCC | Glycerolipid metabolism | 41/4020 | 63/8465 | 3.59e-03 | 1.12e-02 | 6.22e-03 | 41 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LCLAT1 | SNV | Missense_Mutation | rs780206248 | c.547G>A | p.Glu183Lys | p.E183K | Q6UWP7 | protein_coding | tolerated(0.18) | benign(0.106) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
LCLAT1 | SNV | Missense_Mutation | rs769660456 | c.778N>T | p.Ala260Ser | p.A260S | Q6UWP7 | protein_coding | deleterious(0.01) | possibly_damaging(0.889) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
LCLAT1 | SNV | Missense_Mutation | rs374373733 | c.946N>T | p.Arg316Cys | p.R316C | Q6UWP7 | protein_coding | deleterious(0.01) | benign(0.007) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
LCLAT1 | SNV | Missense_Mutation | c.208N>T | p.Met70Leu | p.M70L | Q6UWP7 | protein_coding | tolerated(0.22) | benign(0.031) | TCGA-AG-3591-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unspecific | Complete Response | ||
LCLAT1 | SNV | Missense_Mutation | rs750655578 | c.452N>T | p.Ala151Val | p.A151V | Q6UWP7 | protein_coding | deleterious(0.04) | benign(0.196) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
LCLAT1 | SNV | Missense_Mutation | novel | c.877C>A | p.Leu293Ile | p.L293I | Q6UWP7 | protein_coding | tolerated(0.22) | benign(0.122) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LCLAT1 | SNV | Missense_Mutation | rs745720629 | c.1135N>A | p.Val379Ile | p.V379I | Q6UWP7 | protein_coding | tolerated(0.42) | benign(0) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
LCLAT1 | SNV | Missense_Mutation | novel | c.833N>T | p.Pro278Leu | p.P278L | Q6UWP7 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-AP-A05O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
LCLAT1 | SNV | Missense_Mutation | c.154N>C | p.Phe52Leu | p.F52L | Q6UWP7 | protein_coding | tolerated(0.07) | benign(0.018) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
LCLAT1 | SNV | Missense_Mutation | c.701N>T | p.Arg234Ile | p.R234I | Q6UWP7 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |