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Gene: LBH |
Gene summary for LBH |
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Gene information | Species | Human | Gene symbol | LBH | Gene ID | 81606 |
Gene name | LBH regulator of WNT signaling pathway | |
Gene Alias | LBH | |
Cytomap | 2p23.1 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q53QV2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81606 | LBH | P128T-E | Human | Esophagus | ESCC | 8.41e-61 | 3.20e+00 | 0.1241 |
81606 | LBH | P130T-E | Human | Esophagus | ESCC | 6.30e-47 | 1.07e+00 | 0.1676 |
81606 | LBH | C04 | Human | Oral cavity | OSCC | 2.60e-11 | -2.04e-01 | 0.2633 |
81606 | LBH | C21 | Human | Oral cavity | OSCC | 4.35e-06 | -2.87e-01 | 0.2678 |
81606 | LBH | C30 | Human | Oral cavity | OSCC | 5.17e-05 | 4.33e-01 | 0.3055 |
81606 | LBH | C43 | Human | Oral cavity | OSCC | 9.69e-06 | -3.42e-01 | 0.1704 |
81606 | LBH | C57 | Human | Oral cavity | OSCC | 2.69e-03 | -2.17e-01 | 0.1679 |
81606 | LBH | C08 | Human | Oral cavity | OSCC | 3.14e-14 | 7.10e-01 | 0.1919 |
81606 | LBH | C09 | Human | Oral cavity | OSCC | 9.15e-06 | 9.57e-02 | 0.1431 |
81606 | LBH | NEOLP-2 | Human | Oral cavity | NEOLP | 6.07e-07 | 5.66e-01 | -0.0196 |
81606 | LBH | NEOLP-3 | Human | Oral cavity | NEOLP | 1.57e-05 | 4.57e-01 | -0.0191 |
81606 | LBH | SYSMH1 | Human | Oral cavity | OSCC | 3.75e-10 | -3.09e-01 | 0.1127 |
81606 | LBH | SYSMH3 | Human | Oral cavity | OSCC | 1.09e-04 | -1.64e-01 | 0.2442 |
81606 | LBH | SYSMH4 | Human | Oral cavity | OSCC | 2.83e-11 | -5.19e-01 | 0.1226 |
81606 | LBH | SYSMH5 | Human | Oral cavity | OSCC | 1.97e-13 | -4.66e-01 | 0.0647 |
81606 | LBH | P5_S10_cSCC | Human | Skin | cSCC | 1.92e-08 | 2.59e-01 | -0.299 |
81606 | LBH | P1_cSCC | Human | Skin | cSCC | 3.76e-06 | 4.14e-01 | 0.0292 |
81606 | LBH | P2_cSCC | Human | Skin | cSCC | 1.12e-09 | 5.02e-01 | -0.024 |
81606 | LBH | P4_cSCC | Human | Skin | cSCC | 3.12e-06 | 2.83e-01 | -0.00290000000000005 |
81606 | LBH | Adj_PTCwithHT_6 | Human | Thyroid | HT | 4.52e-03 | -2.64e-01 | 0.02 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00198277 | Esophagus | HGIN | stem cell population maintenance | 39/2587 | 131/18723 | 1.63e-06 | 6.14e-05 | 39 |
GO:00987278 | Esophagus | HGIN | maintenance of cell number | 39/2587 | 134/18723 | 3.02e-06 | 1.03e-04 | 39 |
GO:20007375 | Esophagus | HGIN | negative regulation of stem cell differentiation | 12/2587 | 23/18723 | 1.45e-05 | 4.02e-04 | 12 |
GO:003052220 | Esophagus | HGIN | intracellular receptor signaling pathway | 62/2587 | 265/18723 | 1.63e-05 | 4.50e-04 | 62 |
GO:20007365 | Esophagus | HGIN | regulation of stem cell differentiation | 20/2587 | 58/18723 | 5.65e-05 | 1.33e-03 | 20 |
GO:004854527 | Esophagus | HGIN | response to steroid hormone | 73/2587 | 339/18723 | 6.06e-05 | 1.40e-03 | 73 |
GO:004873225 | Esophagus | HGIN | gland development | 88/2587 | 436/18723 | 1.34e-04 | 2.71e-03 | 88 |
GO:003051818 | Esophagus | HGIN | intracellular steroid hormone receptor signaling pathway | 29/2587 | 116/18723 | 9.06e-04 | 1.15e-02 | 29 |
GO:007138320 | Esophagus | HGIN | cellular response to steroid hormone stimulus | 44/2587 | 204/18723 | 1.56e-03 | 1.79e-02 | 44 |
GO:00305207 | Esophagus | HGIN | intracellular estrogen receptor signaling pathway | 16/2587 | 54/18723 | 1.97e-03 | 2.08e-02 | 16 |
GO:004340118 | Esophagus | HGIN | steroid hormone mediated signaling pathway | 31/2587 | 136/18723 | 3.01e-03 | 2.88e-02 | 31 |
GO:0035019 | Esophagus | HGIN | somatic stem cell population maintenance | 13/2587 | 42/18723 | 3.32e-03 | 3.12e-02 | 13 |
GO:20000362 | Esophagus | HGIN | regulation of stem cell population maintenance | 11/2587 | 33/18723 | 3.55e-03 | 3.26e-02 | 11 |
GO:0048732111 | Esophagus | ESCC | gland development | 269/8552 | 436/18723 | 7.81e-12 | 2.95e-10 | 269 |
GO:0030522110 | Esophagus | ESCC | intracellular receptor signaling pathway | 170/8552 | 265/18723 | 8.58e-10 | 2.09e-08 | 170 |
GO:0048545111 | Esophagus | ESCC | response to steroid hormone | 204/8552 | 339/18723 | 4.47e-08 | 8.11e-07 | 204 |
GO:009872714 | Esophagus | ESCC | maintenance of cell number | 90/8552 | 134/18723 | 3.94e-07 | 5.43e-06 | 90 |
GO:001982714 | Esophagus | ESCC | stem cell population maintenance | 88/8552 | 131/18723 | 5.23e-07 | 6.97e-06 | 88 |
GO:0071383110 | Esophagus | ESCC | cellular response to steroid hormone stimulus | 127/8552 | 204/18723 | 1.26e-06 | 1.55e-05 | 127 |
GO:003051819 | Esophagus | ESCC | intracellular steroid hormone receptor signaling pathway | 76/8552 | 116/18723 | 1.25e-05 | 1.15e-04 | 76 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LBH | SNV | Missense_Mutation | rs201301340 | c.179G>A | p.Arg60His | p.R60H | Q53QV2 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LBH | SNV | Missense_Mutation | c.184C>T | p.Pro62Ser | p.P62S | Q53QV2 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LBH | SNV | Missense_Mutation | rs754393032 | c.286N>A | p.Glu96Lys | p.E96K | Q53QV2 | protein_coding | tolerated_low_confidence(0.13) | benign(0.006) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
LBH | SNV | Missense_Mutation | rs750086364 | c.157N>T | p.Arg53Cys | p.R53C | Q53QV2 | protein_coding | tolerated(0.07) | benign(0.015) | TCGA-D5-6536-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | 5-fu | SD |
LBH | SNV | Missense_Mutation | c.214N>A | p.Glu72Lys | p.E72K | Q53QV2 | protein_coding | deleterious(0.01) | benign(0.443) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
LBH | SNV | Missense_Mutation | c.187N>C | p.Ser63Pro | p.S63P | Q53QV2 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-D1-A177-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
LBH | SNV | Missense_Mutation | novel | c.139G>T | p.Asp47Tyr | p.D47Y | Q53QV2 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-73-4658-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LBH | SNV | Missense_Mutation | novel | c.222G>T | p.Glu74Asp | p.E74D | Q53QV2 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-NK-A5CT-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
LBH | SNV | Missense_Mutation | novel | c.218N>A | p.Val73Glu | p.V73E | Q53QV2 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-CV-A45Z-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
LBH | SNV | Missense_Mutation | novel | c.220N>A | p.Glu74Lys | p.E74K | Q53QV2 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-CV-A45Z-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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