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Gene: KRCC1 |
Gene summary for KRCC1 |
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Gene information | Species | Human | Gene symbol | KRCC1 | Gene ID | 51315 |
Gene name | lysine rich coiled-coil 1 | |
Gene Alias | CHBP2 | |
Cytomap | 2p11.2 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | A0A024R5P4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51315 | KRCC1 | P52T-E | Human | Esophagus | ESCC | 4.67e-25 | 5.41e-01 | 0.1555 |
51315 | KRCC1 | P54T-E | Human | Esophagus | ESCC | 5.28e-16 | 3.90e-01 | 0.0975 |
51315 | KRCC1 | P56T-E | Human | Esophagus | ESCC | 1.99e-02 | 9.44e-01 | 0.1613 |
51315 | KRCC1 | P57T-E | Human | Esophagus | ESCC | 6.76e-27 | 4.96e-01 | 0.0926 |
51315 | KRCC1 | P61T-E | Human | Esophagus | ESCC | 4.53e-29 | 7.57e-01 | 0.099 |
51315 | KRCC1 | P62T-E | Human | Esophagus | ESCC | 3.05e-59 | 1.11e+00 | 0.1302 |
51315 | KRCC1 | P65T-E | Human | Esophagus | ESCC | 2.25e-10 | 2.99e-01 | 0.0978 |
51315 | KRCC1 | P74T-E | Human | Esophagus | ESCC | 7.55e-23 | 7.88e-01 | 0.1479 |
51315 | KRCC1 | P75T-E | Human | Esophagus | ESCC | 2.21e-04 | 1.33e-01 | 0.1125 |
51315 | KRCC1 | P76T-E | Human | Esophagus | ESCC | 1.61e-33 | 6.76e-01 | 0.1207 |
51315 | KRCC1 | P79T-E | Human | Esophagus | ESCC | 1.75e-12 | 2.01e-01 | 0.1154 |
51315 | KRCC1 | P80T-E | Human | Esophagus | ESCC | 1.47e-26 | 1.09e+00 | 0.155 |
51315 | KRCC1 | P82T-E | Human | Esophagus | ESCC | 1.24e-03 | 5.68e-01 | 0.1072 |
51315 | KRCC1 | P83T-E | Human | Esophagus | ESCC | 1.14e-13 | 4.91e-01 | 0.1738 |
51315 | KRCC1 | P84T-E | Human | Esophagus | ESCC | 2.10e-07 | 3.72e-01 | 0.0933 |
51315 | KRCC1 | P89T-E | Human | Esophagus | ESCC | 1.45e-10 | 7.92e-01 | 0.1752 |
51315 | KRCC1 | P91T-E | Human | Esophagus | ESCC | 3.22e-06 | 9.93e-01 | 0.1828 |
51315 | KRCC1 | P107T-E | Human | Esophagus | ESCC | 4.17e-03 | 1.23e-01 | 0.171 |
51315 | KRCC1 | P126T-E | Human | Esophagus | ESCC | 3.64e-04 | 8.39e-01 | 0.1125 |
51315 | KRCC1 | P127T-E | Human | Esophagus | ESCC | 3.29e-15 | 4.19e-01 | 0.0826 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KRCC1 | SNV | Missense_Mutation | novel | c.37N>T | p.Asp13Tyr | p.D13Y | Q9NPI7 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-A8-A09Q-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD |
KRCC1 | SNV | Missense_Mutation | c.15N>T | p.Lys5Asn | p.K5N | Q9NPI7 | protein_coding | tolerated(0.08) | benign(0.051) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
KRCC1 | SNV | Missense_Mutation | c.490C>T | p.Pro164Ser | p.P164S | Q9NPI7 | protein_coding | tolerated(0.76) | benign(0.124) | TCGA-AH-6897-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
KRCC1 | SNV | Missense_Mutation | novel | c.549N>A | p.Ser183Arg | p.S183R | Q9NPI7 | protein_coding | tolerated(0.19) | benign(0.005) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
KRCC1 | SNV | Missense_Mutation | novel | c.357N>A | p.Asn119Lys | p.N119K | Q9NPI7 | protein_coding | deleterious(0.01) | benign(0.232) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
KRCC1 | SNV | Missense_Mutation | rs147560562 | c.164C>T | p.Thr55Met | p.T55M | Q9NPI7 | protein_coding | deleterious(0.02) | benign(0.001) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KRCC1 | SNV | Missense_Mutation | rs779719379 | c.320N>T | p.Thr107Met | p.T107M | Q9NPI7 | protein_coding | deleterious(0.01) | possibly_damaging(0.897) | TCGA-AJ-A8CW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KRCC1 | SNV | Missense_Mutation | c.635N>C | p.Glu212Ala | p.E212A | Q9NPI7 | protein_coding | tolerated(0.3) | benign(0.021) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KRCC1 | SNV | Missense_Mutation | novel | c.764N>A | p.Ser255Tyr | p.S255Y | Q9NPI7 | protein_coding | deleterious(0) | possibly_damaging(0.895) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
KRCC1 | SNV | Missense_Mutation | novel | c.670N>T | p.Asp224Tyr | p.D224Y | Q9NPI7 | protein_coding | deleterious(0.01) | possibly_damaging(0.8) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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