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Gene: KLF12 |
Gene summary for KLF12 |
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Gene information | Species | Human | Gene symbol | KLF12 | Gene ID | 11278 |
Gene name | Kruppel like factor 12 | |
Gene Alias | AP-2rep | |
Cytomap | 13q22.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q8WWI3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11278 | KLF12 | ATC13 | Human | Thyroid | ATC | 7.62e-23 | 5.12e-01 | 0.34 |
11278 | KLF12 | ATC2 | Human | Thyroid | ATC | 3.85e-05 | 4.60e-01 | 0.34 |
11278 | KLF12 | ATC3 | Human | Thyroid | ATC | 4.97e-10 | 4.83e-01 | 0.338 |
11278 | KLF12 | ATC4 | Human | Thyroid | ATC | 1.25e-06 | 1.76e-01 | 0.34 |
11278 | KLF12 | ATC5 | Human | Thyroid | ATC | 2.86e-33 | 5.55e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KLF12 | SNV | Missense_Mutation | novel | c.1054N>A | p.Glu352Lys | p.E352K | Q9Y4X4 | protein_coding | deleterious(0.01) | benign(0.048) | TCGA-A2-A0CR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
KLF12 | SNV | Missense_Mutation | rs762948057 | c.44C>T | p.Thr15Ile | p.T15I | Q9Y4X4 | protein_coding | tolerated_low_confidence(0.19) | benign(0) | TCGA-AN-A04A-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
KLF12 | SNV | Missense_Mutation | novel | c.964G>C | p.Glu322Gln | p.E322Q | Q9Y4X4 | protein_coding | deleterious(0.05) | possibly_damaging(0.607) | TCGA-BH-A28O-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | CR |
KLF12 | insertion | Frame_Shift_Ins | novel | c.907_908insCGGTAAAACATGGCTCACAGCAAGCAAGTCCAGTCCA | p.Gln303ProfsTer17 | p.Q303Pfs*17 | Q9Y4X4 | protein_coding | TCGA-A8-A06P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | SD | |||
KLF12 | SNV | Missense_Mutation | rs375091947 | c.634N>A | p.Val212Met | p.V212M | Q9Y4X4 | protein_coding | deleterious(0.03) | benign(0.178) | TCGA-VS-A8QA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
KLF12 | SNV | Missense_Mutation | novel | c.452N>T | p.Ser151Phe | p.S151F | Q9Y4X4 | protein_coding | deleterious(0) | possibly_damaging(0.462) | TCGA-VS-A959-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
KLF12 | SNV | Missense_Mutation | c.1156N>G | p.Phe386Val | p.F386V | Q9Y4X4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KLF12 | SNV | Missense_Mutation | novel | c.389N>C | p.Ile130Thr | p.I130T | Q9Y4X4 | protein_coding | tolerated(0.22) | possibly_damaging(0.84) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
KLF12 | SNV | Missense_Mutation | c.250N>G | p.Leu84Val | p.L84V | Q9Y4X4 | protein_coding | deleterious(0) | possibly_damaging(0.899) | TCGA-AA-3842-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folinic | PD | |
KLF12 | SNV | Missense_Mutation | novel | c.1075N>A | p.Ala359Thr | p.A359T | Q9Y4X4 | protein_coding | deleterious(0.02) | benign(0.221) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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