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Gene: ISOC1 |
Gene summary for ISOC1 |
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Gene information | Species | Human | Gene symbol | ISOC1 | Gene ID | 51015 |
Gene name | isochorismatase domain containing 1 | |
Gene Alias | CGI-111 | |
Cytomap | 5q23.3 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q96CN7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51015 | ISOC1 | P62T-E | Human | Esophagus | ESCC | 1.40e-45 | 8.50e-01 | 0.1302 |
51015 | ISOC1 | P65T-E | Human | Esophagus | ESCC | 6.49e-14 | 8.75e-02 | 0.0978 |
51015 | ISOC1 | P74T-E | Human | Esophagus | ESCC | 1.59e-32 | 8.72e-01 | 0.1479 |
51015 | ISOC1 | P75T-E | Human | Esophagus | ESCC | 4.38e-22 | 5.21e-01 | 0.1125 |
51015 | ISOC1 | P76T-E | Human | Esophagus | ESCC | 4.87e-15 | 3.44e-01 | 0.1207 |
51015 | ISOC1 | P79T-E | Human | Esophagus | ESCC | 4.74e-14 | 3.30e-01 | 0.1154 |
51015 | ISOC1 | P80T-E | Human | Esophagus | ESCC | 9.84e-40 | 1.36e+00 | 0.155 |
51015 | ISOC1 | P83T-E | Human | Esophagus | ESCC | 1.40e-14 | 4.78e-01 | 0.1738 |
51015 | ISOC1 | P89T-E | Human | Esophagus | ESCC | 2.26e-04 | 2.98e-01 | 0.1752 |
51015 | ISOC1 | P107T-E | Human | Esophagus | ESCC | 4.88e-14 | 4.50e-01 | 0.171 |
51015 | ISOC1 | P127T-E | Human | Esophagus | ESCC | 1.88e-16 | 1.88e-01 | 0.0826 |
51015 | ISOC1 | P128T-E | Human | Esophagus | ESCC | 8.48e-21 | 4.37e-01 | 0.1241 |
51015 | ISOC1 | P130T-E | Human | Esophagus | ESCC | 2.19e-43 | 9.78e-01 | 0.1676 |
51015 | ISOC1 | HCC1_Meng | Human | Liver | HCC | 1.64e-74 | 1.89e-01 | 0.0246 |
51015 | ISOC1 | HCC2_Meng | Human | Liver | HCC | 2.04e-07 | -1.78e-02 | 0.0107 |
51015 | ISOC1 | HCC2 | Human | Liver | HCC | 5.82e-04 | 2.15e+00 | 0.5341 |
51015 | ISOC1 | Pt13.b | Human | Liver | HCC | 2.99e-06 | 7.44e-02 | 0.0251 |
51015 | ISOC1 | S014 | Human | Liver | HCC | 1.25e-13 | 5.33e-01 | 0.2254 |
51015 | ISOC1 | S015 | Human | Liver | HCC | 3.47e-05 | 4.68e-01 | 0.2375 |
51015 | ISOC1 | S016 | Human | Liver | HCC | 1.66e-15 | 4.77e-01 | 0.2243 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ISOC1 | SNV | Missense_Mutation | c.886T>C | p.Ser296Pro | p.S296P | Q96CN7 | protein_coding | tolerated(0.06) | benign(0.003) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
ISOC1 | SNV | Missense_Mutation | novel | c.581N>T | p.Ala194Val | p.A194V | Q96CN7 | protein_coding | deleterious(0.04) | benign(0.22) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ISOC1 | SNV | Missense_Mutation | novel | c.767N>T | p.Gly256Val | p.G256V | Q96CN7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ISOC1 | SNV | Missense_Mutation | c.257N>A | p.Gly86Asp | p.G86D | Q96CN7 | protein_coding | tolerated(0.14) | probably_damaging(0.992) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ISOC1 | SNV | Missense_Mutation | rs778499451 | c.757N>A | p.Ala253Thr | p.A253T | Q96CN7 | protein_coding | tolerated(0.1) | possibly_damaging(0.72) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ISOC1 | SNV | Missense_Mutation | rs370245668 | c.761N>A | p.Arg254Gln | p.R254Q | Q96CN7 | protein_coding | tolerated(1) | benign(0.024) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ISOC1 | SNV | Missense_Mutation | c.476N>C | p.Gln159Pro | p.Q159P | Q96CN7 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ISOC1 | SNV | Missense_Mutation | novel | c.484N>C | p.Lys162Gln | p.K162Q | Q96CN7 | protein_coding | tolerated(0.15) | benign(0.143) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
ISOC1 | SNV | Missense_Mutation | c.392A>G | p.Lys131Arg | p.K131R | Q96CN7 | protein_coding | tolerated(0.31) | benign(0.05) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ISOC1 | SNV | Missense_Mutation | rs760387704 | c.194A>G | p.His65Arg | p.H65R | Q96CN7 | protein_coding | tolerated_low_confidence(0.12) | possibly_damaging(0.84) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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